PMID- 33379194
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220424
IS  - 2072-6694 (Print)
IS  - 2072-6694 (Electronic)
IS  - 2072-6694 (Linking)
VI  - 13
IP  - 1
DP  - 2020 Dec 28
TI  - Connexins and cAMP Cross-Talk in Cancer Progression and Metastasis.
LID - 10.3390/cancers13010058 [doi]
LID - 58
AB  - Connexin-containing gap junctions mediate the direct exchange of small molecules 
      between cells, thus promoting cell-cell communication. Connexins (Cxs) have been 
      widely studied as key tumor-suppressors. However, certain Cx subtypes, such as 
      Cx43 and Cx26, are overexpressed in metastatic tumor lesions. Cyclic adenosine 
      monophosphate (cAMP) signaling regulates Cx expression and function via 
      transcriptional control and phosphorylation. cAMP also passes through gap 
      junction channels between adjacent cells, regulating cell cycle progression, 
      particularly in cancer cell populations. Low levels of cAMP are sufficient to 
      activate key effectors. The present review evaluates the mechanisms underlying Cx 
      regulation by cAMP signaling and the role of gap junctions in cancer progression 
      and metastasis. A deeper understanding of these processes might facilitate the 
      development of novel anticancer drugs.
FAU - Chen, Chang-Xu
AU  - Chen CX
AD  - School of Life Sciences, Yunnan University, Kunming 650500, China.
AD  - Key Laboratory of the University in Yunnan Province for International Cooperation 
      in Intercellular Communications and Regulations, Yunnan University, Kunming 
      650500, China.
FAU - Luo, Kai-Jun
AU  - Luo KJ
AUID- ORCID: 0000-0003-3900-1177
AD  - School of Life Sciences, Yunnan University, Kunming 650500, China.
AD  - Key Laboratory of the University in Yunnan Province for International Cooperation 
      in Intercellular Communications and Regulations, Yunnan University, Kunming 
      650500, China.
FAU - Yang, Jia-Peng
AU  - Yang JP
AD  - Department of Thoracic Surgery I, The Third Affiliated Hospital of Kunming 
      Medical University/Yunnan Cancer Hospital, Yunnan Cancer Center, Kunming 650500, 
      China.
AD  - Joint International Research Laboratory of Regional Tumor in High Altitude Area, 
      Kunming 650118, China.
FAU - Huang, Yun-Chao
AU  - Huang YC
AD  - Department of Thoracic Surgery I, The Third Affiliated Hospital of Kunming 
      Medical University/Yunnan Cancer Hospital, Yunnan Cancer Center, Kunming 650500, 
      China.
AD  - Joint International Research Laboratory of Regional Tumor in High Altitude Area, 
      Kunming 650118, China.
FAU - Cardenas, Eduardo R
AU  - Cardenas ER
AD  - Department of Biochemistry and Structural Biology, University of Texas Health 
      Science Center, San Antonio, TX 78229, USA.
FAU - Nicholson, Bruce J
AU  - Nicholson BJ
AD  - Department of Biochemistry and Structural Biology, University of Texas Health 
      Science Center, San Antonio, TX 78229, USA.
FAU - Jiang, Jean X
AU  - Jiang JX
AD  - Department of Biochemistry and Structural Biology, University of Texas Health 
      Science Center, San Antonio, TX 78229, USA.
LA  - eng
GR  - R01 CA196214/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20201228
PL  - Switzerland
TA  - Cancers (Basel)
JT  - Cancers
JID - 101526829
PMC - PMC7795795
OTO - NOTNLM
OT  - cAMP
OT  - cancer
OT  - connexin
OT  - metastasis
COIS- The authors declare no conflict of interest.
EDAT- 2021/01/01 06:00
MHDA- 2021/01/01 06:01
PMCR- 2020/12/28
CRDT- 2020/12/31 01:02
PHST- 2020/11/25 00:00 [received]
PHST- 2020/12/21 00:00 [revised]
PHST- 2020/12/21 00:00 [accepted]
PHST- 2020/12/31 01:02 [entrez]
PHST- 2021/01/01 06:00 [pubmed]
PHST- 2021/01/01 06:01 [medline]
PHST- 2020/12/28 00:00 [pmc-release]
AID - cancers13010058 [pii]
AID - cancers-13-00058 [pii]
AID - 10.3390/cancers13010058 [doi]
PST - epublish
SO  - Cancers (Basel). 2020 Dec 28;13(1):58. doi: 10.3390/cancers13010058.