PMID- 33380161
OWN - NLM
STAT- MEDLINE
DCOM- 20210510
LR  - 20210510
IS  - 1940-1574 (Electronic)
IS  - 0003-3197 (Linking)
VI  - 72
IP  - 5
DP  - 2021 May
TI  - Improving the Assessment of Flow-Mediated Dilation Through Detection of Peak Time 
      in Healthy Subjects and Subjects With Type 2 Diabetes.
PG  - 434-441
LID - 10.1177/0003319720984884 [doi]
AB  - The assessment of flow-mediated dilation (FMD) is widely used to quantify 
      endothelial function. Historically, FMD was determined at 60 seconds post-cuff 
      deflation. We investigated whether FMD would be more accurate if determined at 
      maximum dilatory peak (MDP) than at 60 seconds in healthy subjects and subjects 
      with type 2 diabetes mellitus (T2DM). We studied 95 healthy and 72 subjects with 
      T2DM and assessed FMD at MDP, 60 and 90 seconds. Twenty-four healthy and 12 
      subjects with T2DM underwent a repeat FMD after 28 days. In healthy subjects, FMD 
      at MDP was higher than at 60 and 90 seconds, with mean difference MDP versus 60 
      seconds 1.14% (95% CI: 0.6-1.7); P < .0001 and MDP versus 90 seconds 1.9% (95% 
      CI: 1.3-2.5) with similar results in T2DM, that is, 1.0% (95% CI: 0.1-1.9) and 
      2.3% (95% CI: 1.3-3.2), respectively. Intraindividual variability was lowest with 
      MDP compared with 60 and 90 seconds, that is, 15.0 versus 23.2% and 40.0%, 
      respectively, resulting in a more than 2-fold reduction in necessary sample size. 
      In healthy subjects and subjects with T2DM, assessment of FMD using MDP results 
      in a more accurate and precise assessment leading to a substantial reduction in 
      sample size.
FAU - Herbrand, Theresa
AU  - Herbrand T
AUID- ORCID: 0000-0003-4534-3982
AD  - Profil Institut fur Stoffwechselforschung GmbH, Neuss, Germany.
FAU - Coester, Hans-Veit
AU  - Coester HV
AD  - Profil Institut fur Stoffwechselforschung GmbH, Neuss, Germany.
FAU - Sansone, Roberto
AU  - Sansone R
AD  - Division of Cardiology, Pulmonology, and Vascular Medicine, Medical Faculty, 
      University of Dusseldorf, Dusseldorf, Germany.
FAU - Fischer, Annelie
AU  - Fischer A
AD  - Profil Institut fur Stoffwechselforschung GmbH, Neuss, Germany.
FAU - Heiss, Christian
AU  - Heiss C
AD  - Department of Clinical and Experimental Medicine, Faculty of Health and Medical 
      Sciences, 3660University of Surrey, Guildford, UK.
FAU - Heise, Tim
AU  - Heise T
AD  - Profil Institut fur Stoffwechselforschung GmbH, Neuss, Germany.
FAU - Kelm, Malte
AU  - Kelm M
AD  - Division of Cardiology, Pulmonology, and Vascular Medicine, Medical Faculty, 
      University of Dusseldorf, Dusseldorf, Germany.
FAU - DeVries, J Hans
AU  - DeVries JH
AD  - Profil Institut fur Stoffwechselforschung GmbH, Neuss, Germany.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
DEP - 20201230
PL  - United States
TA  - Angiology
JT  - Angiology
JID - 0203706
SB  - IM
MH  - Brachial Artery/*diagnostic imaging/physiopathology
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/complications/*diagnostic imaging/physiopathology
MH  - Diabetic Angiopathies/*diagnostic imaging/etiology/physiopathology
MH  - Female
MH  - Germany
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Observer Variation
MH  - Reproducibility of Results
MH  - Sample Size
MH  - Time Factors
MH  - *Ultrasonography
MH  - *Vasodilation
OTO - NOTNLM
OT  - endothelial dysfunction
OT  - flow-mediated dilation
OT  - type 2 diabetes
EDAT- 2021/01/01 06:00
MHDA- 2021/05/11 06:00
CRDT- 2020/12/31 05:17
PHST- 2021/01/01 06:00 [pubmed]
PHST- 2021/05/11 06:00 [medline]
PHST- 2020/12/31 05:17 [entrez]
AID - 10.1177/0003319720984884 [doi]
PST - ppublish
SO  - Angiology. 2021 May;72(5):434-441. doi: 10.1177/0003319720984884. Epub 2020 Dec 
      30.