PMID- 33381643
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231110
IS  - 2578-5125 (Print)
IS  - 2378-8763 (Electronic)
IS  - 2378-8763 (Linking)
VI  - 5
IP  - 4
DP  - 2020
TI  - Cannabinoids in the Management of Acute Pain: A Systematic Review and 
      Meta-analysis.
PG  - 290-297
LID - 10.1089/can.2019.0079 [doi]
AB  - Objective: To synthesize the best evidence surrounding the efficacy of 
      cannabinoids for acute pain in the clinical setting based on subjective pain 
      scores and observed adverse effects. Design: Systematic review with 
      meta-analysis. Data Sources: PubMed, Embase, Cochrane Databases, and Google 
      Scholar. Eligibility Criteria: English-language randomized-controlled clinical 
      trials comparing cannabinoids with placebo in patients with acute pain. Data 
      Extraction and Synthesis: Study quality was assessed using the Cochrane risk of 
      bias tool. All stages were conducted independently by a team of three reviewers. 
      Data were pooled through meta-analysis and stratified by route of administration. 
      Primary Outcomes and Measures: Patient-reported pain and adverse events (AEs). 
      Results: Six trials (678 participants) were included examining oral (5 trials) 
      and intramuscular (1 trial) cannabinoids. Overall, there was a small but 
      statistically significant treatment effect favoring the use of cannabinoids over 
      placebo (-0.90, 95% confidence interval [CI] -1.69 to -0.1, i (2)=65%, p=0.03). 
      When stratified by route of administration, intramuscular cannabinoids were found 
      to have a significant reduction in pain relative to placebo (-2.98, 95% CI -4.09 
      to -1.87, i (2)=0%, p<0.0001). No difference in effect was observed between oral 
      cannabinoids and placebo (-0.21, 95% CI -0.64 to 0.22, i (2)=3%, p=0.34). Serious 
      AEs were rare, and similar across the cannabinoid (14/374, 3.7%) and placebo 
      groups (8/304, 2.6%). Conclusions: There is low-quality evidence indicating that 
      cannabinoids may be a safe alternative for a small but significant reduction in 
      subjective pain score when treating acute pain, with intramuscular administration 
      resulting in a greater reduction relative to oral. Higher quality, long-term 
      randomized-controlled trials examining whether there may be a role for 
      cannabinoids in treating acute pain are required.
CI  - Copyright 2020, Mary Ann Liebert, Inc., publishers.
FAU - Gazendam, Aaron
AU  - Gazendam A
AD  - Center for Evidence-Based Orthopaedics, Division of Orthopaedic Surgery, 
      Department of Surgery, McMaster University, Hamilton, Canada.
FAU - Nucci, Nicholas
AU  - Nucci N
AD  - Northern Ontario School of Medicine, Lakehead University, Thunder Bay, Canada.
FAU - Gouveia, Kyle
AU  - Gouveia K
AD  - Michael G. DeGroote School of Medicine, Faculty of Health Sciences, McMaster 
      University, Hamilton, Canada.
FAU - Abdel Khalik, Hassaan
AU  - Abdel Khalik H
AD  - Michael G. DeGroote School of Medicine, Faculty of Health Sciences, McMaster 
      University, Hamilton, Canada.
FAU - Rubinger, Luc
AU  - Rubinger L
AD  - Center for Evidence-Based Orthopaedics, Division of Orthopaedic Surgery, 
      Department of Surgery, McMaster University, Hamilton, Canada.
FAU - Johal, Herman
AU  - Johal H
AD  - Center for Evidence-Based Orthopaedics, Division of Orthopaedic Surgery, 
      Department of Surgery, McMaster University, Hamilton, Canada.
AD  - Department of Health Research Methods, Evidence and Impact, McMaster University, 
      Hamilton, Canada.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20201215
PL  - United States
TA  - Cannabis Cannabinoid Res
JT  - Cannabis and cannabinoid research
JID - 101684827
PMC - PMC7759255
OTO - NOTNLM
OT  - acute pain
OT  - cannabinoids
OT  - meta-analysis
OT  - surgical pain
OT  - systematic review
COIS- No competing financial interests exist.
EDAT- 2021/01/01 06:00
MHDA- 2021/01/01 06:01
PMCR- 2021/12/15
CRDT- 2020/12/31 05:27
PHST- 2020/12/31 05:27 [entrez]
PHST- 2021/01/01 06:00 [pubmed]
PHST- 2021/01/01 06:01 [medline]
PHST- 2021/12/15 00:00 [pmc-release]
AID - 10.1089/can.2019.0079 [pii]
AID - 10.1089/can.2019.0079 [doi]
PST - epublish
SO  - Cannabis Cannabinoid Res. 2020 Dec 15;5(4):290-297. doi: 10.1089/can.2019.0079. 
      eCollection 2020.