PMID- 33381872
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210325
IS  - 1386-6346 (Print)
IS  - 1386-6346 (Linking)
VI  - 51
IP  - 3
DP  - 2021 Mar
TI  - Hepatocellular adenoma, approximately half and predominantly inflammatory 
      subtype, in 38 Japanese patients with several differences in age, gender, and 
      clinical background factors from Western populations.
PG  - 336-342
LID - 10.1111/hepr.13613 [doi]
AB  - AIM: Hepatocellular adenoma (HCA) has a lower prevalence in Japan than in Western 
      countries and HCA subtypes have been reported for only a few Japanese patients. 
      We analyzed HCA subtype data 38 patients from 23 hospitals in Japan in order to 
      examine character and difference between Western countries. METHODS: To confirm 
      HCA and to analyze subtypes, we performed immunohistochemical examinations. 
      RESULTS: Thirty-eight cases were found to have HCA without cirrhosis. The 
      male/female ratio was 18/20. Ages ranged from 15 to 79 (average, 43.2) years. 
      Male and elder patients are not rare, furthermore, most of elder patients are 
      male. Glycogen storage disease, past history of medicament use, hepatitis B virus 
      surface antigen-positivity, antihepatitis C virus -positivity, diabetes mellitus, 
      obesity, lipid metabolism disorder and alcoholism were present in of 6, 8, 1, 1, 
      6, 6, 4, and 6 cases, respectively. As to HCA subtypes, HNF1alpha-inactivated 
      HCA, beta-catenin activated HCA (b-HCA), inflammatory HCA (IHCA) and unclassified 
      HCA (U-HCA) accounted for nine (23.7%), four (10.5%), 17 (44.7%) and eight 
      (21.1%) cases, respectively. Two cases showed coexistence of HCA and 
      hepatocellular carcinoma (HCC) at surgery, and another had HCC which had been 
      detected 23 years after HCA diagnosis. The HCA subtype of one of the former cases 
      was U-HCA, while the remaining two had b-HCA and U-HCA. CONCLUSIONS: In Japanese 
      HCA cases, the proportions of U-HCA, male and elder cases were slightly higher 
      than in Western countries, and most of elder patients were male. IHCA was however 
      common regardless of race, and was assumed to be the predominant subtype of HCA.
CI  - (c) 2020 The Japan Society of Hepatology.
FAU - Izu, Asami
AU  - Izu A
AD  - Department of Pathology, Nihon University School of Medicine, Tokyo, Japan.
AD  - Department of Diagnostic Pathology, Saitama Medical University International 
      Medical Center, Hidaka, Saitama, Japan.
FAU - Sugitani, Masahiko
AU  - Sugitani M
AUID- ORCID: 0000-0001-8170-2538
AD  - Department of Pathology, Nihon University School of Medicine, Tokyo, Japan.
AD  - Department of Diagnostic Pathology, Ageo Central General Hospital, Ageo, Saitama, 
      Japan.
FAU - Kinukawa, Noriko
AU  - Kinukawa N
AD  - Department of Pathology, Nihon University School of Medicine, Tokyo, Japan.
AD  - Department of Diagnostic Pathology, Ageo Central General Hospital, Ageo, Saitama, 
      Japan.
FAU - Matsumura, Hiroshi
AU  - Matsumura H
AD  - Division of Gastroenterology and Hepatology, Department of Medicine, Nihon 
      University School of Medicine, Tokyo, Japan.
FAU - Ogawa, Masahiro
AU  - Ogawa M
AD  - Division of Gastroenterology and Hepatology, Department of Medicine, Nihon 
      University School of Medicine, Tokyo, Japan.
FAU - Moriyama, Mitsuhiko
AU  - Moriyama M
AD  - Division of Gastroenterology and Hepatology, Department of Medicine, Nihon 
      University School of Medicine, Tokyo, Japan.
FAU - Yamazaki, Shintaro
AU  - Yamazaki S
AD  - Department of Digestive Surgery, Nihon University School of Medicine, Tokyo, 
      Japan.
FAU - Takayama, Tadatoshi
AU  - Takayama T
AD  - Department of Digestive Surgery, Nihon University School of Medicine, Tokyo, 
      Japan.
FAU - Hano, Hiroshi
AU  - Hano H
AD  - Department of Pathology, Jikei University School of Medicine, Tokyo, Japan.
FAU - Yao, Takashi
AU  - Yao T
AD  - Department of Human Pathology, Juntendo University Graduate School of Medicine, 
      Tokyo, Japan.
FAU - Kanda, Hiroaki
AU  - Kanda H
AD  - Department of Pathology, The Cancer Institute of Japanese Foundation for Cancer 
      Research, Tokyo, Japan.
AD  - Department of Pathology, Saitama Cancer Center, Ina, Saitama, Japan.
FAU - Suzuki, Koyu
AU  - Suzuki K
AD  - Department of Pathology, Saint Luke's International Hospital, Tokyo, Japan.
FAU - Hayashi, Seisyu
AU  - Hayashi S
AD  - Department of Internal Medicine, Tokyo Metropolitan Cancer and Infectious 
      Diseases Center Komagome Hospital, Tokyo, Japan.
FAU - Ariizumi, Syunichi
AU  - Ariizumi S
AD  - Department of Gastroenterological Surgery, Tokyo Women's Medical University, 
      Tokyo, Japan.
FAU - Yamamoto, Masakazu
AU  - Yamamoto M
AD  - Department of Gastroenterological Surgery, Tokyo Women's Medical University, 
      Tokyo, Japan.
FAU - Morishita, Yukio
AU  - Morishita Y
AD  - Diagnostic Pathology Division, Tokyo Medical University Ibaraki Medical Center, 
      Ibaraki, Japan.
FAU - Matsumoto, Koshi
AU  - Matsumoto K
AD  - Pathology Division, Ebina General Hospital, Ebina, Kanagawa, Japan.
FAU - Nakamura, Naoya
AU  - Nakamura N
AD  - Department of Pathology, Tokai University School of Medicine, Isehara, Kanagawa, 
      Japan.
FAU - Nakano, Masayuki
AU  - Nakano M
AD  - Tokyo Central Pathology Laboratory, Tokyo, Japan.
LA  - eng
PT  - Journal Article
DEP - 20210222
PL  - Netherlands
TA  - Hepatol Res
JT  - Hepatology research : the official journal of the Japan Society of Hepatology
JID - 9711801
OTO - NOTNLM
OT  - WHO classification
OT  - epidemiology
OT  - hepatocellular adenoma
OT  - subtype
EDAT- 2021/01/01 06:00
MHDA- 2021/01/01 06:01
CRDT- 2020/12/31 05:29
PHST- 2020/12/15 00:00 [revised]
PHST- 2020/07/29 00:00 [received]
PHST- 2020/12/16 00:00 [accepted]
PHST- 2021/01/01 06:00 [pubmed]
PHST- 2021/01/01 06:01 [medline]
PHST- 2020/12/31 05:29 [entrez]
AID - 10.1111/hepr.13613 [doi]
PST - ppublish
SO  - Hepatol Res. 2021 Mar;51(3):336-342. doi: 10.1111/hepr.13613. Epub 2021 Feb 22.