PMID- 33382101
OWN - NLM
STAT- MEDLINE
DCOM- 20211021
LR  - 20220531
IS  - 1943-3670 (Electronic)
IS  - 0022-3492 (Linking)
VI  - 92
IP  - 9
DP  - 2021 Sep
TI  - The effects of a novel non-invasive application of platelet-rich fibrin on 
      periodontal clinical parameters and gingival crevicular fluid transforming growth 
      factor-beta and collagen-1 levels: A randomized, controlled, clinical study.
PG  - 1252-1261
LID - 10.1002/JPER.20-0713 [doi]
AB  - BACKGROUND: Several potential benefits have been attributed to the platelet-rich 
      fibrin (PRF), including enhanced tissue healing properties. In this study, we 
      hypothesized that the application of PRF as an adjunct to conventional scaling 
      and root planing (ScRp) would enhance the outcomes of non-surgical periodontal 
      therapy. METHODS: The present study was a split-mouth randomized controlled 
      clinical trial design in 24 deep periodontal pockets in 12 patients with 
      periodontitis. The pockets were randomly assigned as test or control. The test 
      group received PRF as an adjunct to ScRp, whereas the control group received ScRp 
      only. We measured periodontal clinical parameters at baseline, 3, and 6 months 
      after the treatments. To study the initial healing in response to treatment, 
      transforming growth factor-beta (TGF-beta) and collagen-1 (Col-1) in gingival 
      crevicular fluid (GCF) were measured using enzyme-linked immunosorbent assay at 
      baseline, third, seventh, and 14th days. RESULTS: The test group showed a 
      significantly greater pocket reduction, higher clinical attachment gain, and less 
      gingival recession than the control group at 3 and 6 months. The test Col-1 
      levels (1.27 +/- 1.05, 1.35 +/- 0.76, 0.97 +/- 0.53 ng/site) and TGF-beta levels (11.93 +/- 
      2.68, 12.54 +/- 3.66, 17.19 +/- 11.66 pg/site) were higher than the control Col-1 
      levels (0.76 +/- 0.20, 0.84 +/- 0.24, 0.57 +/- 0.19 ng/site) and TGF-beta levels (6.34 +/- 
      1.67, 6.35 +/- 3.44, 7.51 +/- 2.85 pg/site) at all measurement days respectively. 
      CONCLUSIONS: Non-surgical application of the PRF as an adjunct to conventional 
      ScRp may effectively improve the periodontal clinical parameters via increasing 
      expression of the GCF TGF-beta and Col-1 levels.
CI  - (c) 2020 American Academy of Periodontology.
FAU - Ozcan, Erkan
AU  - Ozcan E
AD  - Gulhane Dentistry Faculty, Department of Periodontology, University of Health 
      Sciences, Ankara, Turkey.
FAU - Saygun, Isil
AU  - Saygun I
AD  - Gulhane Dentistry Faculty, Department of Periodontology, University of Health 
      Sciences, Ankara, Turkey.
FAU - Kantarci, Alpdogan
AU  - Kantarci A
AD  - Forsyth Institute, Cambridge, Massachusetts, USA.
FAU - Ozarslanturk, Savas
AU  - Ozarslanturk S
AD  - Gulhane Dentistry Faculty, Department of Oral and Maxillofacial Radiology, 
      University of Health Sciences, Ankara, Turkey.
FAU - Serdar, Muhittin A
AU  - Serdar MA
AD  - Department of Biochemistry, Acibadem University, Ankara, Turkey.
FAU - Ozgurtas, Taner
AU  - Ozgurtas T
AD  - Gulhane Medical Faculty, Department of Biochemistry, Health Sciences University, 
      Ankara, Turkey.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20210115
PL  - United States
TA  - J Periodontol
JT  - Journal of periodontology
JID - 8000345
RN  - 0 (Collagen Type I)
RN  - 0 (Transforming Growth Factor beta)
SB  - IM
MH  - Collagen Type I/*blood
MH  - Dental Scaling
MH  - *Gingival Crevicular Fluid
MH  - Humans
MH  - Periodontal Index
MH  - *Platelet-Rich Fibrin
MH  - Root Planing
MH  - Transforming Growth Factor beta/*blood
OTO - NOTNLM
OT  - collagen-type 1
OT  - gingival crevicular fluid
OT  - platelet-rich fibrin
OT  - regeneration
OT  - root planing
OT  - transforming growth factor beta
EDAT- 2021/01/01 06:00
MHDA- 2021/10/26 06:00
CRDT- 2020/12/31 08:37
PHST- 2020/12/16 00:00 [revised]
PHST- 2020/09/30 00:00 [received]
PHST- 2020/12/16 00:00 [accepted]
PHST- 2021/01/01 06:00 [pubmed]
PHST- 2021/10/26 06:00 [medline]
PHST- 2020/12/31 08:37 [entrez]
AID - 10.1002/JPER.20-0713 [doi]
PST - ppublish
SO  - J Periodontol. 2021 Sep;92(9):1252-1261. doi: 10.1002/JPER.20-0713. Epub 2021 Jan 
      15.