PMID- 33384617
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210102
IS  - 1664-042X (Print)
IS  - 1664-042X (Electronic)
IS  - 1664-042X (Linking)
VI  - 11
DP  - 2020
TI  - The Relationship Between Simple Renal Cysts and Renal Function in Patients With 
      Type 2 Diabetes.
PG  - 616167
LID - 10.3389/fphys.2020.616167 [doi]
LID - 616167
AB  - Introduction: Simple renal cysts (SRCs) are the most common acquired cystic 
      kidney disease, but the relationship between SRCs and renal function has not been 
      clarified in patients with type 2 diabetes mellitus (T2DM). Methods: A 
      retrospective study was conducted to analyze the clinical features of renal cysts 
      and ultrasound data of the kidney in 4,304 patients with T2DM. Results: The 
      prevalence of SRCs in patients with T2DM was 21.1%. Compared to patients with no 
      SRCs, patients with SRCs had worse renal function (estimated glomerular 
      filtration rate: 108.65 +/- 40.93 vs. 92.38 +/- 42.1 ml/min/1.73 m(2), p < 0.05). 
      After adjusting the confounders, SRC was related to estimated glomerular 
      filtration rate in patients with T2DM [odds ratio = 1.49, 95% confidence interval 
      (1.24, 1.79), p < 0.01]. Age, gout, proteinuria, cerebrovascular disease (CVD), 
      and increased serum phosphorus levels were associated with SRCs in patients with 
      T2DM. Conclusion: SRCs are associated with worse renal function in patients with 
      T2DM. More attention should be paid to gout, proteinuria, CVD, serum phosphorus 
      levels, and renal function in T2DM patients with SRCs.
CI  - Copyright (c) 2020 Wei, Xiao, Xiong, Li, Yang, Han, Zhao, Yang and Sun.
FAU - Wei, Ling
AU  - Wei L
AD  - Hunan Key Laboratory of Kidney Disease and Blood Purification, Department of 
      Nephrology, The Second Xiangya Hospital, Central South University, Changsha, 
      China.
FAU - Xiao, Ying
AU  - Xiao Y
AD  - Hunan Key Laboratory of Kidney Disease and Blood Purification, Department of 
      Nephrology, The Second Xiangya Hospital, Central South University, Changsha, 
      China.
FAU - Xiong, Xiaofen
AU  - Xiong X
AD  - Hunan Key Laboratory of Kidney Disease and Blood Purification, Department of 
      Nephrology, The Second Xiangya Hospital, Central South University, Changsha, 
      China.
FAU - Li, Li
AU  - Li L
AD  - Hunan Key Laboratory of Kidney Disease and Blood Purification, Department of 
      Nephrology, The Second Xiangya Hospital, Central South University, Changsha, 
      China.
FAU - Yang, Yuan
AU  - Yang Y
AD  - Hunan Key Laboratory of Kidney Disease and Blood Purification, Department of 
      Nephrology, The Second Xiangya Hospital, Central South University, Changsha, 
      China.
FAU - Han, Yachun
AU  - Han Y
AD  - Hunan Key Laboratory of Kidney Disease and Blood Purification, Department of 
      Nephrology, The Second Xiangya Hospital, Central South University, Changsha, 
      China.
FAU - Zhao, Hao
AU  - Zhao H
AD  - Hunan Key Laboratory of Kidney Disease and Blood Purification, Department of 
      Nephrology, The Second Xiangya Hospital, Central South University, Changsha, 
      China.
FAU - Yang, Ming
AU  - Yang M
AD  - Hunan Key Laboratory of Kidney Disease and Blood Purification, Department of 
      Nephrology, The Second Xiangya Hospital, Central South University, Changsha, 
      China.
FAU - Sun, Lin
AU  - Sun L
AD  - Hunan Key Laboratory of Kidney Disease and Blood Purification, Department of 
      Nephrology, The Second Xiangya Hospital, Central South University, Changsha, 
      China.
LA  - eng
PT  - Journal Article
DEP - 20201215
PL  - Switzerland
TA  - Front Physiol
JT  - Frontiers in physiology
JID - 101549006
PMC - PMC7770177
OTO - NOTNLM
OT  - estimated glomerular filtration rate
OT  - proteinuria
OT  - renal function
OT  - simple renal cysts
OT  - type 2 diabetes
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/01/02 06:00
MHDA- 2021/01/02 06:01
PMCR- 2020/12/15
CRDT- 2021/01/01 05:21
PHST- 2020/10/11 00:00 [received]
PHST- 2020/11/23 00:00 [accepted]
PHST- 2021/01/01 05:21 [entrez]
PHST- 2021/01/02 06:00 [pubmed]
PHST- 2021/01/02 06:01 [medline]
PHST- 2020/12/15 00:00 [pmc-release]
AID - 10.3389/fphys.2020.616167 [doi]
PST - epublish
SO  - Front Physiol. 2020 Dec 15;11:616167. doi: 10.3389/fphys.2020.616167. eCollection 
      2020.