PMID- 33385559
OWN - NLM
STAT- MEDLINE
DCOM- 20210301
LR  - 20210926
IS  - 1095-9572 (Electronic)
IS  - 1053-8119 (Print)
IS  - 1053-8119 (Linking)
VI  - 227
DP  - 2021 Feb 15
TI  - fMRI-Indexed neural temporal tuning reveals the hierarchical organsiation of the 
      face and person selective network.
PG  - 117690
LID - S1053-8119(20)31175-7 [pii]
LID - 10.1016/j.neuroimage.2020.117690 [doi]
AB  - Recognising and knowing about conspecifics is vital to human interaction and is 
      served in the brain by a well-characterised cortical network. Understanding the 
      temporal dynamics of this network is critical to gaining insight into both 
      hierarchical organisation and regional coordination. Here, we combine the high 
      spatial resolution of fMRI with a paradigm that permits investigation of 
      differential temporal tuning across cortical regions. We cognitively under- and 
      overload the system using the rapid presentation (100-1200msec) of famous faces 
      and buildings. We observed an increase in activity as presentation rates slowed 
      and a negative deflection when inter-stimulus intervals (ISIs) were extended to 
      longer periods. The primary distinction in tuning patterns was between core 
      (perceptual) and extended (non-perceptual) systems but there was also evidence 
      for nested hierarchies within systems, as well as indications of widespread 
      parallel processing. Extended regions demonstrated common temporal tuning across 
      regions which may indicate coordinated activity as they cooperate to manifest the 
      diverse cognitive representation accomplished by this network. With the support 
      of an additional psychophysical study, we demonstrated that ISIs necessary for 
      different levels of semantic access are consistent with temporal tuning patterns. 
      Collectively, these results show that regions of the person-knowledge network 
      operate over different temporal timescales consistent with hierarchical 
      organisation.
CI  - Copyright (c) 2020. Published by Elsevier Inc.
FAU - Ubaldi, Silvia
AU  - Ubaldi S
AD  - Center for Mind/Brain Sciences (CIMeC), University of Trento, Corso Bettini 31, 
      Rovereto, TN 38068, Italy.
FAU - Fairhall, Scott L
AU  - Fairhall SL
AD  - Center for Mind/Brain Sciences (CIMeC), University of Trento, Corso Bettini 31, 
      Rovereto, TN 38068, Italy. Electronic address: scott.fairhall@unitn.it.
LA  - eng
GR  - 640594/ERC_/European Research Council/International
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20201229
PL  - United States
TA  - Neuroimage
JT  - NeuroImage
JID - 9215515
SB  - IM
MH  - Adult
MH  - Brain/*physiology
MH  - Brain Mapping/methods
MH  - Facial Recognition/*physiology
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging/methods
MH  - Male
MH  - Young Adult
PMC - PMC7611695
MID - EMS134933
OTO - NOTNLM
OT  - Face perception
OT  - Network-dynamics
OT  - Place perception
EDAT- 2021/01/02 06:00
MHDA- 2021/03/02 06:00
PMCR- 2021/09/23
CRDT- 2021/01/01 20:08
PHST- 2020/07/28 00:00 [received]
PHST- 2020/12/24 00:00 [revised]
PHST- 2020/12/25 00:00 [accepted]
PHST- 2021/01/02 06:00 [pubmed]
PHST- 2021/03/02 06:00 [medline]
PHST- 2021/01/01 20:08 [entrez]
PHST- 2021/09/23 00:00 [pmc-release]
AID - S1053-8119(20)31175-7 [pii]
AID - 10.1016/j.neuroimage.2020.117690 [doi]
PST - ppublish
SO  - Neuroimage. 2021 Feb 15;227:117690. doi: 10.1016/j.neuroimage.2020.117690. Epub 
      2020 Dec 29.