PMID- 33385765
OWN - NLM
STAT- MEDLINE
DCOM- 20210311
LR  - 20231110
IS  - 1878-0334 (Electronic)
IS  - 1871-4021 (Print)
IS  - 1871-4021 (Linking)
VI  - 15
IP  - 1
DP  - 2021 Jan-Feb
TI  - Impaired anti-SARS-CoV-2 antibody response in non-severe COVID-19 patients with 
      diabetes mellitus: A preliminary report.
PG  - 193-196
LID - S1871-4021(20)30530-0 [pii]
LID - 10.1016/j.dsx.2020.12.035 [doi]
AB  - BACKGROUND AND AIMS: Patients with diabetes mellitus (DM) often demonstrate 
      impaired antibody response to influenza/hepatitis B vaccines. Hence, we compared 
      anti-SARS-CoV-2 antibody response in non-severe COVID-19 patients with and 
      without type 2 diabetes mellitus (T2DM). METHODS: Records of non-severe COVID-19 
      patients admitted at our institution between April 10, 2020 and May 20, 2020 were 
      retrieved. Qualitative detection of total (IgG + IgM) anti-SARS-CoV-2 antibody 
      was performed using electrochemiluminescence immunoassay in plasma samples 
      collected at least 14 days post-polymerase chain reaction (PCR) confirmation of 
      diagnosis. RESULTS: Thirty-one non-severe COVID-19 patients were included. Nine 
      patients (29%) had T2DM with mean HbA(1c) at admission of 8.3 +/- 1.0%. 
      Anti-SARS-CoV-2 antibody was estimated at a median of 16 (14-17) days post-PCR 
      confirmation of COVID-19 diagnosis. Only three patients (10%) were seronegative, 
      and all had T2DM. Patients with T2DM were more likely to have non-detectable 
      anti-SARS-CoV-2 antibodies than those without DM (p = 0.019). CONCLUSIONS: 
      COVID-19 patients with T2DM may not undergo seroconversion even after two weeks 
      of diagnosis. Impaired seroconversion could theoretically increase the risk of 
      reinfections in patients with DM. However, the finding requires validation in 
      large-scale studies involving serial estimations of anti-SARS-CoV-2 antibodies in 
      patients with and without DM.
CI  - Copyright (c) 2020 Diabetes India. Published by Elsevier Ltd. All rights reserved.
FAU - Pal, Rimesh
AU  - Pal R
AD  - Department of Endocrinology, Post Graduate Institute of Medical Education and 
      Research, Chandigarh, 160012, India.
FAU - Sachdeva, Naresh
AU  - Sachdeva N
AD  - Department of Endocrinology, Post Graduate Institute of Medical Education and 
      Research, Chandigarh, 160012, India. Electronic address: 
      naresh.sachdeva@outlook.com.
FAU - Mukherjee, Soham
AU  - Mukherjee S
AD  - Department of Endocrinology, Post Graduate Institute of Medical Education and 
      Research, Chandigarh, 160012, India.
FAU - Suri, Vikas
AU  - Suri V
AD  - Department of Internal Medicine, Post Graduate Institute of Medical Education and 
      Research, Chandigarh, 160012, India.
FAU - Zohmangaihi, Deepy
AU  - Zohmangaihi D
AD  - Department of Biochemistry, Post Graduate Institute of Medical Education and 
      Research, Chandigarh, 160012, India.
FAU - Ram, Sant
AU  - Ram S
AD  - Department of Biochemistry, Post Graduate Institute of Medical Education and 
      Research, Chandigarh, 160012, India.
FAU - Puri, Goverdhan Dutt
AU  - Puri GD
AD  - Department of Anesthesiology, Post Graduate Institute of Medical Education and 
      Research, Chandigarh, 160012, India.
FAU - Bhalla, Ashish
AU  - Bhalla A
AD  - Department of Internal Medicine, Post Graduate Institute of Medical Education and 
      Research, Chandigarh, 160012, India.
FAU - Soni, Shiv Lal
AU  - Soni SL
AD  - Department of Anesthesiology, Post Graduate Institute of Medical Education and 
      Research, Chandigarh, 160012, India.
FAU - Pandey, Navin
AU  - Pandey N
AD  - Department of Hospital Administration, Post Graduate Institute of Medical 
      Education and Research, Chandigarh, 160012, India.
FAU - Bhansali, Anil
AU  - Bhansali A
AD  - Department of Endocrinology, Post Graduate Institute of Medical Education and 
      Research, Chandigarh, 160012, India.
FAU - Bhadada, Sanjay Kumar
AU  - Bhadada SK
AD  - Department of Endocrinology, Post Graduate Institute of Medical Education and 
      Research, Chandigarh, 160012, India. Electronic address: 
      bhadadask@rediffmail.com.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20201225
PL  - Netherlands
TA  - Diabetes Metab Syndr
JT  - Diabetes & metabolic syndrome
JID - 101462250
RN  - 0 (Antibodies, Viral)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Antibodies, Viral/*blood/immunology
MH  - Antibody Formation/*physiology
MH  - COVID-19/*blood/epidemiology/immunology
MH  - COVID-19 Testing/*trends
MH  - Diabetes Mellitus, Type 2/*blood/epidemiology/immunology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - SARS-CoV-2/immunology/*metabolism
MH  - Young Adult
PMC - PMC7762626
OTO - NOTNLM
OT  - Antibodies
OT  - COVID-19
OT  - Humoral immunity
OT  - T2DM
COIS- Declaration of competing interest The authors declare no conflicts of interest.
EDAT- 2021/01/02 06:00
MHDA- 2021/03/12 06:00
PMCR- 2020/12/25
CRDT- 2021/01/01 20:11
PHST- 2020/12/15 00:00 [received]
PHST- 2020/12/18 00:00 [revised]
PHST- 2020/12/20 00:00 [accepted]
PHST- 2021/01/02 06:00 [pubmed]
PHST- 2021/03/12 06:00 [medline]
PHST- 2021/01/01 20:11 [entrez]
PHST- 2020/12/25 00:00 [pmc-release]
AID - S1871-4021(20)30530-0 [pii]
AID - 10.1016/j.dsx.2020.12.035 [doi]
PST - ppublish
SO  - Diabetes Metab Syndr. 2021 Jan-Feb;15(1):193-196. doi: 10.1016/j.dsx.2020.12.035. 
      Epub 2020 Dec 25.