PMID- 33386169
OWN - NLM
STAT- MEDLINE
DCOM- 20211111
LR  - 20211111
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Linking)
VI  - 82
IP  - 4
DP  - 2021 Apr
TI  - Critical amino acid variants in HLA-DRB1 allotypes in the development of Graves' 
      disease and Hashimoto's thyroiditis in the Japanese population.
PG  - 226-231
LID - S0198-8859(20)30441-9 [pii]
LID - 10.1016/j.humimm.2020.12.007 [doi]
AB  - The effects of amino acid variants encoded by human leukocyte antigen (HLA) class 
      II on the development of Graves' disease (GD) and Hashimoto's thyroiditis (HT) 
      have not been fully elucidated. We investigated the HLA-DRB1 genes of 243 GD 
      patients and 82 HT patients in the Japanese population and compared the 
      frequencies of HLA-DRB1 alleles and HLA-DRB1 amino acid variants between these 
      patients and the Japanese populations previously reported by another institution. 
      The frequencies of HLA-DRB1*04:05 and -DRB1*14:03 alleles were significantly 
      higher and those of HLA-DRB1*01:01 and -DRB1*15:02 alleles were lower in GD 
      patients than in controls. The frequencies of HLA-DRB1*08:03 and -DRB1*09:01 
      alleles were significantly higher and that of the HLA-DRB1*13:02 allele was lower 
      in HT patients than in controls. A blind association analysis with all amino acid 
      positions identified DRss9 and DRss31 for GD and DRss9, DRss13, and DRss21 for HT. The 
      frequency of Glu-9 was significantly higher and that of Cys-9 was lower in GD 
      patients than in controls. The frequencies of Lys-9 and Phe-13 were significantly 
      higher in HT patients than in controls. DRss9 and DRss13 could be critical amino 
      acid positions in the development of GD and HT.
CI  - Copyright (c) 2020 American Society for Histocompatibility and Immunogenetics. 
      Published by Elsevier Inc. All rights reserved.
FAU - Katahira, Masahito
AU  - Katahira M
AD  - Aichi Prefectural University School of Nursing and Health, Nagoya, Japan; 
      Department of Endocrinology and Diabetes, Ichinomiya Municipal Hospital, 
      Ichinomiya, Japan. Electronic address: katahira-0034@umin.net.
FAU - Ogata, Hidetada
AU  - Ogata H
AD  - Department of Endocrinology and Diabetes, Ichinomiya Municipal Hospital, 
      Ichinomiya, Japan.
FAU - Takashima, Hiromi
AU  - Takashima H
AD  - Department of Endocrinology and Diabetes, Ichinomiya Municipal Hospital, 
      Ichinomiya, Japan.
FAU - Ito, Takahiro
AU  - Ito T
AD  - Department of Endocrinology and Diabetes, Ichinomiya Municipal Hospital, 
      Ichinomiya, Japan.
FAU - Hodai, Yuichi
AU  - Hodai Y
AD  - Department of Endocrinology and Diabetes, Ichinomiya Municipal Hospital, 
      Ichinomiya, Japan; Department of Endocrinology and Diabetes, Nagoya University 
      Graduate School of Medicine, Nagoya, Japan.
FAU - Miwata, Tsutomu
AU  - Miwata T
AD  - Department of Endocrinology and Diabetes, Ichinomiya Municipal Hospital, 
      Ichinomiya, Japan; Department of Endocrinology and Diabetes, Nagoya University 
      Graduate School of Medicine, Nagoya, Japan.
FAU - Goto, Megumi
AU  - Goto M
AD  - Department of Endocrinology and Diabetes, Ichinomiya Municipal Hospital, 
      Ichinomiya, Japan.
FAU - Yamaguchi, Mariko
AU  - Yamaguchi M
AD  - Department of Endocrinology and Diabetes, Ichinomiya Municipal Hospital, 
      Ichinomiya, Japan.
FAU - Mizoguchi, Akira
AU  - Mizoguchi A
AD  - Department of Endocrinology and Diabetes, Ichinomiya Municipal Hospital, 
      Ichinomiya, Japan.
FAU - Kawakubo, Mitsuhiro
AU  - Kawakubo M
AD  - Department of Endocrinology and Diabetes, Ichinomiya Municipal Hospital, 
      Ichinomiya, Japan; Department of Internal Medicine, Nishio Municipal Hospital, 
      Nishio, Japan.
FAU - Nakamura, Shizuka
AU  - Nakamura S
AD  - Department of Endocrinology and Diabetes, Ichinomiya Municipal Hospital, 
      Ichinomiya, Japan.
LA  - eng
PT  - Journal Article
DEP - 20201230
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (Amino Acids)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Alleles
MH  - Amino Acids/*genetics
MH  - Female
MH  - Gene Frequency
MH  - Genetic Association Studies
MH  - Genetic Predisposition to Disease
MH  - *Genotype
MH  - Graves Disease/genetics/*immunology
MH  - HLA-DRB1 Chains/*genetics
MH  - Hashimoto Disease/genetics/*immunology
MH  - Humans
MH  - Japan
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Genetic
OTO - NOTNLM
OT  - Amino acid variants
OT  - Graves' disease
OT  - HLA class II
OT  - Hashimoto's thyroiditis
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2021/01/03 06:00
MHDA- 2021/11/12 06:00
CRDT- 2021/01/02 05:15
PHST- 2020/07/14 00:00 [received]
PHST- 2020/10/27 00:00 [revised]
PHST- 2020/12/11 00:00 [accepted]
PHST- 2021/01/03 06:00 [pubmed]
PHST- 2021/11/12 06:00 [medline]
PHST- 2021/01/02 05:15 [entrez]
AID - S0198-8859(20)30441-9 [pii]
AID - 10.1016/j.humimm.2020.12.007 [doi]
PST - ppublish
SO  - Hum Immunol. 2021 Apr;82(4):226-231. doi: 10.1016/j.humimm.2020.12.007. Epub 2020 
      Dec 30.