PMID- 33386442
OWN - NLM
STAT- MEDLINE
DCOM- 20210621
LR  - 20210621
IS  - 1434-3916 (Electronic)
IS  - 0936-8051 (Linking)
VI  - 141
IP  - 4
DP  - 2021 Apr
TI  - The use of 2-octyl cyanoacrylate as an adjuvant to wound closure in total knee 
      arthroplasty.
PG  - 663-668
LID - 10.1007/s00402-020-03674-2 [doi]
AB  - PURPOSE: The efficacy of the use of 2-octyl cyanoacrylate (OCA) as an adjuvant to 
      wound closure in preventing wound complications after total knee arthroplasty 
      (TKA) is rarely reported. This study was aimed to determine whether the use of 
      OCA as a supplement to conventional wound closure reduces the incidence of wound 
      complications following TKA. PATIENTS AND METHODS: This retrospective study 
      reviewed 1106 consecutive patients who underwent TKA for symptomatic end-stage 
      osteoarthritis (OA) between 2012 and 2017. The first 562 patients who did not 
      receive OCA were grouped into the Control group, and the subsequent 544 patients 
      who received OCA as an adjuvant to wound closure were grouped into the OCA group. 
      All patients were followed up for at least 2 years. The main outcome was the 
      development of operative site complications, including aseptic and infectious 
      complications. Aseptic wound complications were wound leakage, hematoma, wound 
      dehiscence and delayed wound healing, and infectious complication was mainly 
      referred to the superficial infection. RESULTS: No significant difference with 
      regard to hematoma was observed between groups (3.0% vs. 3.7%, P = 0.617, 
      phi = - 0.02). The incidences were significantly higher in the Control group versus 
      the OCA group in regard to wound leakage (9.4% vs. 2.0%, P = 0.000, phi = 0.16), 
      wound dehiscence (5.7% vs. 1.3%, P = 0.000, phi = 0.12), delayed wound healing 
      (4.4% vs. 1.5%, P = 0.004, phi = 0.09) and superficial infection (2.0% vs. 0.4%, 
      P = 0.022, phi = 0.07). No serious adverse events (AEs) occurred. CONCLUSIONS: The 
      present study showed that the addition of OCA reduced the incidence of wound 
      leakage, wound dehiscence, delayed wound healing and superficial infection after 
      TKA compared to conventional wound closure. Based on the outcomes above, we 
      decide to use OCA routinely for wound closure after TKA. LEVEL OF EVIDENCE: III, 
      retrospective, cohort study.
FAU - Xu, Xinxian
AU  - Xu X
AD  - The Osteopathy Department, The Second Affiliated Hospital and Yuying Children's 
      Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
FAU - Liu, Haixiao
AU  - Liu H
AD  - The Osteopathy Department, The Second Affiliated Hospital and Yuying Children's 
      Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
FAU - Zhang, Yu
AU  - Zhang Y
AD  - The Osteopathy Department, The Second Affiliated Hospital and Yuying Children's 
      Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
FAU - Xue, Enxing
AU  - Xue E
AD  - The Osteopathy Department, The Second Affiliated Hospital and Yuying Children's 
      Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
FAU - Yu, Huachen
AU  - Yu H
AD  - The Osteopathy Department, The Second Affiliated Hospital and Yuying Children's 
      Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
FAU - Hu, Yuezheng
AU  - Hu Y
AUID- ORCID: 0000-0002-6192-4114
AD  - The Osteopathy Department, The Second Affiliated Hospital and Yuying Children's 
      Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China. 
      huyuezheng3@163.com.
LA  - eng
GR  - 2019KY107/Zhejiang Province Public Welfare Technology Application Research 
      Project/
PT  - Journal Article
DEP - 20210102
PL  - Germany
TA  - Arch Orthop Trauma Surg
JT  - Archives of orthopaedic and trauma surgery
JID - 9011043
RN  - 0 (Cyanoacrylates)
RN  - 6C655P1XVG (octyl 2-cyanoacrylate)
SB  - IM
MH  - *Arthroplasty, Replacement, Knee/adverse effects/methods
MH  - Cyanoacrylates/*therapeutic use
MH  - Humans
MH  - Postoperative Complications/epidemiology
MH  - Retrospective Studies
MH  - *Wound Closure Techniques
OTO - NOTNLM
OT  - Dermabond
OT  - Total knee arthroplasty (TKA)
OT  - Wound closure
OT  - Wound complications
EDAT- 2021/01/03 06:00
MHDA- 2021/06/22 06:00
CRDT- 2021/01/02 05:18
PHST- 2020/02/07 00:00 [received]
PHST- 2020/10/28 00:00 [accepted]
PHST- 2021/01/03 06:00 [pubmed]
PHST- 2021/06/22 06:00 [medline]
PHST- 2021/01/02 05:18 [entrez]
AID - 10.1007/s00402-020-03674-2 [pii]
AID - 10.1007/s00402-020-03674-2 [doi]
PST - ppublish
SO  - Arch Orthop Trauma Surg. 2021 Apr;141(4):663-668. doi: 
      10.1007/s00402-020-03674-2. Epub 2021 Jan 2.