PMID- 33386522
OWN - NLM
STAT- MEDLINE
DCOM- 20211014
LR  - 20211014
IS  - 1864-6433 (Electronic)
IS  - 0914-7187 (Linking)
VI  - 35
IP  - 2
DP  - 2021 Feb
TI  - Semi-quantification of renal perfusion using (99m)Tc-DTPA in systolic heart 
      failure: a feasibility study.
PG  - 187-194
LID - 10.1007/s12149-020-01556-6 [doi]
AB  - BACKGROUND: Renal scintigraphy with (99m)Tc-diethylenetriaminepentaacetic acid 
      (DTPA) may be used to study renal perfusion (RP) in heart failure (HF) patients. 
      The goal of this study was to establish a new method to assess RP in patients 
      with systolic HF. METHODS: In this retrospective, single-center, observational 
      study, 86 subjects with left ventricular ejection fraction </= 45% and 31 
      age-matched subjects without HF underwent renal scintigraphy with (99m)Tc-DTPA. 
      Patients with HF were classified into two categories according to the New York 
      Heart Association (NYHA) functional class, i.e., moderate HF with NYHA functional 
      class I or II and severe HF with NYHA functional class III or IV. The first-pass 
      time-activity curve of the renal scintigraph was recorded. The GFR was determined 
      by Gates' method. The time to peak perfusion activity (T(p)), the slope of the 
      perfusion phase (S(p)), the slope of the washout phase (S(w)), and glomerular 
      filtration rate (GFR) in the study were obtained. Differences between groups were 
      assessed by one-way analysis of variance with the Bonferroni post hoc test and 
      rank-sum test. RESULTS: RP in HF was impaired despite comparable GFRs between the 
      control and HF groups. RP in HF was characterized by a longer T(p) and a 
      shallower S(p) and S(w). The primary parameter (T(p)) was significantly prolonged 
      in patients with HF (41.63 +/- 12.22 s in severe HF vs. 26.95 +/- 6.26 s in moderate 
      HF vs. 17.84 +/- 3.17 s in control, P < 0.001). At a cutoff point of 22 s, there 
      was a high sensitivity (0.895) and specificity (0.935) in identifying patients 
      with HF. CONCLUSIONS: Renal scintigraphy with (99m)Tc-DTPA may represent a new 
      and useful method to noninvasively monitor RP abnormalities in HF.
FAU - Ma, Haifang
AU  - Ma H
AD  - Heart Failure Center, The First Hospital of Hebei Medical University, Hebei 
      Medical University, 89 Donggang Road, Shijiazhuang City, 050031, Hebei Province, 
      China.
AD  - Cardiovascular Research Center of Hebei Medical University, Shijiazhuang City, 
      Hebei Province, China.
FAU - Gao, Xian
AU  - Gao X
AD  - Health Institute of The First Hospital of Hebei Medical University, Shijiazhuang 
      City, Hebei Province, China.
FAU - Yin, Pei
AU  - Yin P
AD  - Division of Nuclear Medicine, The First Hospital of Hebei Medical University, 
      Shijiazhuang City, Hebei Province, China.
FAU - Zhao, Qingzhen
AU  - Zhao Q
AD  - Heart Failure Center, The First Hospital of Hebei Medical University, Hebei 
      Medical University, 89 Donggang Road, Shijiazhuang City, 050031, Hebei Province, 
      China.
FAU - Zhen, Yuzhi
AU  - Zhen Y
AD  - Heart Failure Center, The First Hospital of Hebei Medical University, Hebei 
      Medical University, 89 Donggang Road, Shijiazhuang City, 050031, Hebei Province, 
      China.
FAU - Wang, Yu
AU  - Wang Y
AD  - Heart Failure Center, The First Hospital of Hebei Medical University, Hebei 
      Medical University, 89 Donggang Road, Shijiazhuang City, 050031, Hebei Province, 
      China.
FAU - Liu, Kunshen
AU  - Liu K
AD  - Heart Failure Center, The First Hospital of Hebei Medical University, Hebei 
      Medical University, 89 Donggang Road, Shijiazhuang City, 050031, Hebei Province, 
      China.
FAU - Liu, Chao
AU  - Liu C
AUID- ORCID: 0000-0002-5323-6733
AD  - Heart Failure Center, The First Hospital of Hebei Medical University, Hebei 
      Medical University, 89 Donggang Road, Shijiazhuang City, 050031, Hebei Province, 
      China. dr.liuchao@gmail.com.
AD  - Cardiovascular Research Center of Hebei Medical University, Shijiazhuang City, 
      Hebei Province, China. dr.liuchao@gmail.com.
LA  - eng
GR  - No. 81670357/National Natural Science Foundation of China/
GR  - CY201615/Human Resources and Social Security of Hebei Province/
PT  - Journal Article
DEP - 20210101
PL  - Japan
TA  - Ann Nucl Med
JT  - Annals of nuclear medicine
JID - 8913398
RN  - 0 (Radiopharmaceuticals)
RN  - VW78417PU1 (Technetium Tc 99m Pentetate)
RN  - Renal Adysplasia
SB  - IM
MH  - Adult
MH  - Aged
MH  - Feasibility Studies
MH  - Female
MH  - Glomerular Filtration Rate
MH  - Heart Failure, Systolic/*physiopathology
MH  - Humans
MH  - Kidney/abnormalities
MH  - Kidney Function Tests/*methods
MH  - Male
MH  - Middle Aged
MH  - Perfusion
MH  - Radiopharmaceuticals/*chemistry
MH  - Retrospective Studies
MH  - Stroke Volume
MH  - Technetium Tc 99m Pentetate/*chemistry
MH  - Urogenital Abnormalities
MH  - Ventricular Function, Left
OTO - NOTNLM
OT  - 99mTc-DTPA
OT  - Heart failure
OT  - Renal perfusion
OT  - Renal scintigraphy
EDAT- 2021/01/03 06:00
MHDA- 2021/10/15 06:00
CRDT- 2021/01/02 05:19
PHST- 2020/08/27 00:00 [received]
PHST- 2020/11/09 00:00 [accepted]
PHST- 2021/01/03 06:00 [pubmed]
PHST- 2021/10/15 06:00 [medline]
PHST- 2021/01/02 05:19 [entrez]
AID - 10.1007/s12149-020-01556-6 [pii]
AID - 10.1007/s12149-020-01556-6 [doi]
PST - ppublish
SO  - Ann Nucl Med. 2021 Feb;35(2):187-194. doi: 10.1007/s12149-020-01556-6. Epub 2021 
      Jan 1.