PMID- 33386786
OWN - NLM
STAT- MEDLINE
DCOM- 20240325
LR  - 20240325
IS  - 0125-877X (Print)
IS  - 0125-877X (Linking)
VI  - 42
IP  - 1
DP  - 2024 Mar
TI  - Killer cell immunoglobulin-like receptors in Thai patients with multiple myeloma.
PG  - 77-80
LID - 10.12932/AP-130520-0842 [doi]
AB  - BACKGROUND: Natural killer (NK) cells have been implicated in the immune response 
      against multiple myeloma (MM) cells. Killer cell immunoglobulin-like receptors 
      (KIRs) regulate NK cell activity by recognizing specific human leukocyte antigen 
      (HLA) class I as ligands. OBJECTIVE: To investigate the association of KIR genes 
      and ligands with MM in the Thai population. METHODS: KIR gene polymorphisms and 
      their HLA ligands were investigated in 66 Thai patients with MM and 200 healthy 
      controls. RESULTS: The frequencies of KIR3DL1 and 2DS4 were significantly lower 
      in myeloma patients than in controls (P = 0.02). The frequencies of KIR3DL1, 
      2DS4, 2DL1 with C2, and 3DL1 with Bw4 were significantly higher in the patients 
      achieving > very good partial response (VGPR) than those achieving </= VGPR after 
      treatment with bortezomib (P = 0.009, 0.009, 0.01, and 0.02, respectively). 
      CONCLUSIONS: This study suggests the association of KIR genes with the protection 
      against MM and the association of inhibitory KIR and ligands with the response to 
      treatment in MM.
FAU - Theeranawakam, Aphiradee
AU  - Theeranawakam A
AD  - Department of Transfusion Medicine, Faculty of Medicine, Siriraj Hospital, 
      Mahidol University, Bangkok, Thailand.
FAU - Vejbaesya, Sasijit
AU  - Vejbaesya S
AD  - Department of Transfusion Medicine, Faculty of Medicine, Siriraj Hospital, 
      Mahidol University, Bangkok, Thailand.
FAU - Khuhapinant, Archrob
AU  - Khuhapinant A
AD  - Department of Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol 
      University, Bangkok, Thailand.
FAU - Sae-Tam, Pradermchai
AU  - Sae-Tam P
AD  - Department of Transfusion Medicine, Faculty of Medicine, Siriraj Hospital, 
      Mahidol University, Bangkok, Thailand.
LA  - eng
PT  - Journal Article
PL  - Thailand
TA  - Asian Pac J Allergy Immunol
JT  - Asian Pacific journal of allergy and immunology
JID - 8402034
RN  - 0 (Receptors, KIR)
SB  - IM
MH  - Humans
MH  - *Multiple Myeloma/drug therapy/genetics
MH  - Thailand
MH  - Receptors, KIR/genetics
MH  - Polymorphism, Genetic
MH  - Killer Cells, Natural
MH  - Genotype
EDAT- 2021/01/03 06:00
MHDA- 2024/03/25 06:42
CRDT- 2021/01/02 12:06
PHST- 2024/03/25 06:42 [medline]
PHST- 2021/01/03 06:00 [pubmed]
PHST- 2021/01/02 12:06 [entrez]
AID - 10.12932/AP-130520-0842 [doi]
PST - ppublish
SO  - Asian Pac J Allergy Immunol. 2024 Mar;42(1):77-80. doi: 10.12932/AP-130520-0842.