PMID- 33387219
OWN - NLM
STAT- MEDLINE
DCOM- 20211126
LR  - 20211126
IS  - 1573-2584 (Electronic)
IS  - 0301-1623 (Linking)
VI  - 53
IP  - 7
DP  - 2021 Jul
TI  - The prevalence of metabolic syndrome is increased in patients with 
      anti-neutrophil cytoplasmic antibody-associated vasculitis.
PG  - 1427-1434
LID - 10.1007/s11255-020-02736-z [doi]
AB  - PURPOSE: Cardiovascular disease is one of the major causes of mortality in 
      anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV). Metabolic 
      syndrome (MetS) is associated with increased cardiovascular risk in the normal 
      population. However, MetS in AAV has not been adequately investigated. We aimed 
      to determine MetS prevalence and associated factors in AAV patients. METHODS: 
      Thirty-seven AAV patients and 42 healthy controls were enrolled. MetS was 
      determined by International Diabetes Federation (IDF) and National Cholesterol 
      Education Program Adult Treatment Panel III (NCEP-ATPIII) criteria. The 
      relationship between clinical features of AAV and MetS was also investigated. 
      RESULTS: MetS was significantly higher in AAV patients than controls by 
      NCEP-ATPIII (51.4% vs. 26.2%, p 0.022) and IDF (62.2% vs. 35.7%, p 0.020). When 
      AAV patients with MetS were compared to those without, there were significant 
      differences in age, CRP, GFR and NT-pro-BNP. Age [58 (13) vs. 50 (8) years p: 
      0.028], CRP [4.0 (3.6) vs. 3.2 (1.0) mg/l, p 0.021] and NT-pro-BNP [173.5 (343.7) 
      vs. 106.0 (103.0) pg/ml, p 0.013] were significantly higher in AAV patients with 
      MetS than those without; GFR was significantly lower [38 (46) vs. 83 (51) 
      ml/min/1.73 m(2), p 0.004]. ROC curve analysis showed NT-pro-BNP > 58.0 ng/ml 
      predicted MetS with 87.1% sensitivity and 46.7% specificity (Area under curve: 
      0.71, CI 0.536-0.902, p 0.041). Multivariate analysis revealed age [OR (95% CI): 
      1.180 (1.010-1.370), p 0.039] and NT-pro-BNP > 58 pg/ml [OR (95% CI): 5.5 
      (1.02-30.1) p 0.047] were independent predictors of MetS in AAV patients. 
      CONCLUSION: MetS is significantly higher in AAV patients than controls and is 
      associated with age and NT-pro-BNP. Screening and treating MetS may improve 
      prognosis in AAV patients.
FAU - Atas, Dilek Barutcu
AU  - Atas DB
AUID- ORCID: 0000-0002-3090-4479
AD  - School of Medicine, Department of Internal Medicine, Division of Nephrology, 
      Marmara University, Istanbul, Turkey.
FAU - Atas, Halil
AU  - Atas H
AD  - School of Medicine, Department of Cardiology, Marmara University, Istanbul, 
      Turkey.
FAU - Izgi, Tuba Nur
AU  - Izgi TN
AD  - School of Medicine, Department of Internal Medicine, Marmara University, 
      Istanbul, Turkey.
FAU - Velioglu, Arzu
AU  - Velioglu A
AUID- ORCID: 0000-0001-9750-7585
AD  - School of Medicine, Department of Internal Medicine, Division of Nephrology, 
      Marmara University, Istanbul, Turkey.
FAU - Arikan, Hakki
AU  - Arikan H
AUID- ORCID: 0000-0001-6195-1932
AD  - School of Medicine, Department of Internal Medicine, Division of Nephrology, 
      Marmara University, Istanbul, Turkey.
FAU - Oner, Fatma Alibaz
AU  - Oner FA
AD  - School of Medicine, Department of Internal Medicine, Division of Rheumatology, 
      Marmara University, Istanbul, Turkey.
FAU - Direskeneli, Haner
AU  - Direskeneli H
AD  - School of Medicine, Department of Internal Medicine, Division of Rheumatology, 
      Marmara University, Istanbul, Turkey.
FAU - Tuglular, Serhan
AU  - Tuglular S
AUID- ORCID: 0000-0002-6384-1697
AD  - School of Medicine, Department of Internal Medicine, Division of Nephrology, 
      Marmara University, Istanbul, Turkey.
FAU - Asicioglu, Ebru
AU  - Asicioglu E
AUID- ORCID: 0000-0002-5685-115X
AD  - School of Medicine, Department of Internal Medicine, Division of Nephrology, 
      Marmara University, Istanbul, Turkey. easicioglu@yahoo.com.
AD  - Pendik Teaching and Training Hospital, Marmara University, Fevzi Cakmak Mah. 
      MuhsinYazicioglu Cad. No: 10 Ust Kaynarca-Pendik, Istanbul, Turkey. 
      easicioglu@yahoo.com.
LA  - eng
PT  - Journal Article
DEP - 20210102
PL  - Netherlands
TA  - Int Urol Nephrol
JT  - International urology and nephrology
JID - 0262521
SB  - IM
MH  - Adult
MH  - Anti-Neutrophil Cytoplasmic Antibody-Associated 
      Vasculitis/*complications/*etiology
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - Metabolic Syndrome/*epidemiology
MH  - Middle Aged
MH  - Prevalence
MH  - Risk Factors
OTO - NOTNLM
OT  - ANCA
OT  - Granulomatosis with polyangiitis
OT  - Metabolic syndrome
OT  - Microscopic polyangiitis
OT  - Vasculitis
EDAT- 2021/01/03 06:00
MHDA- 2021/11/27 06:00
CRDT- 2021/01/02 12:10
PHST- 2020/06/22 00:00 [received]
PHST- 2020/12/02 00:00 [accepted]
PHST- 2021/01/03 06:00 [pubmed]
PHST- 2021/11/27 06:00 [medline]
PHST- 2021/01/02 12:10 [entrez]
AID - 10.1007/s11255-020-02736-z [pii]
AID - 10.1007/s11255-020-02736-z [doi]
PST - ppublish
SO  - Int Urol Nephrol. 2021 Jul;53(7):1427-1434. doi: 10.1007/s11255-020-02736-z. Epub 
      2021 Jan 2.