PMID- 33387437
OWN - NLM
STAT- MEDLINE
DCOM- 20210105
LR  - 20220419
IS  - 1426-9686 (Print)
IS  - 1426-9686 (Linking)
VI  - 48
IP  - 288
DP  - 2020 Dec 22
TI  - [Veillonella atypica in tumor as a tripartite interaction: commensal - tumor - 
      patient].
PG  - 452-456
AB  - Veillonella spp is part of the normal flora of the mouth, bowels and vagina, but 
      in most of the studies the immunomodulatory properties of intestinal microbiota 
      was described. Despite of numerous studies on immunomodulatory activity of the 
      microbiome's, most of them are focused on the intestinal microbiome. On the 
      contrary, last finding of lung cancer patients shows higher level of 
      Capnocytophaga and Veillonella, which may serve as potential biomarkers. 
      Unfortunately, in local tumor microenvironment the competition for access to 
      oxygen and nutrients within the microbiological context are not strictly 
      described. In the case report such unique interaction with importance in clinical 
      course of non small cell lung cancer (NSCLC) was described. A CASE REPORT: 
      Patient with NSCLC was admitted to surgical procedure. Unluckily, patients before 
      therapy suffered brain trauma (metastases and meningitis were excluded). The 
      oncologic intervention delayed: patients has not receive neoadjuvant 
      chemotherapy. Within near 2 months the infectious process dominated with high 
      acute phase reaction. It predominated over the process of cancer with significant 
      decrease of initial tumor size. After surgical procedure histological examination 
      showed 60% of the tumor was necrotic. Microbiological analysis of tumor specimen 
      reveal Veillonella spp., identified as Veillonella atypica with high abundance. 
      Because the serious complication patients do not receive adjuvant chemotherapy: 
      the surgical resection was complicated by severe systemic inflammatory response 
      syndrome (SIRS) but with low level lactate. CONCLUSIONS: Our observation indicate 
      significant role of commensal anaerobic bacteria in clinical history of cancer 
      patient, opportunistic type of infectious process as well as therapeuthic 
      prospect: proliferative potential and anaerobic glycolysis of commensal 
      Veillonella reduce access of cancer cells to nutrition's. It shed light on 
      crucial role of innate immune response, acute phase reaction and neutrophils in 
      immunotherapy outcome. Contrary to previous studies with statistical coexistence 
      of several bacteria and cancer our observation was evidence-based: tumor specimen 
      was microbiologically analysed.
CI  - (c) 2020 MEDPRESS.
FAU - Zdziarski, PRZEMYSlAW
AU  - Zdziarski P
AD  - Lower Silesian Center for Pulmonary Disease, and Hirszfeld Institute of 
      Immunology and Experimenthal Therapy, Wroclaw, Poland.
LA  - pol
PT  - Case Reports
PT  - Journal Article
TT  - Veillonella atypica w guzie: trojstronna interakcja komensal - nowotwor - chory.
PL  - Poland
TA  - Pol Merkur Lekarski
JT  - Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego
JID - 9705469
RN  - Veillonella atypica
SB  - IM
MH  - *Carcinoma, Non-Small-Cell Lung
MH  - Female
MH  - Humans
MH  - *Lung Neoplasms/drug therapy
MH  - Mouth
MH  - Tumor Microenvironment
MH  - Veillonella
OTO - NOTNLM
OT  - Veillonella
OT  - Warburg effect
OT  - acute phase reaction
OT  - alkaline phosphatase
OT  - anaerobic metabolism
OT  - hypoxia
OT  - immunotherapy
OT  - innate immunity
OT  - lactate
OT  - lung cancer
OT  - microbiome
OT  - pathogen associated molecular patterns (PAMPs)
EDAT- 2021/01/03 06:00
MHDA- 2021/01/06 06:00
CRDT- 2021/01/02 17:02
PHST- 2021/01/02 17:02 [entrez]
PHST- 2021/01/03 06:00 [pubmed]
PHST- 2021/01/06 06:00 [medline]
AID - PML288-452 [pii]
PST - ppublish
SO  - Pol Merkur Lekarski. 2020 Dec 22;48(288):452-456.