PMID- 33389057 OWN - NLM STAT- MEDLINE DCOM- 20220314 LR - 20220314 IS - 1433-8491 (Electronic) IS - 0940-1334 (Linking) VI - 272 IP - 2 DP - 2022 Mar TI - Co-occurrence of schizo-obsessive traits and its correlation with altered executive control network functional connectivity. PG - 301-312 LID - 10.1007/s00406-020-01222-y [doi] AB - The prevalence of obsessive-compulsive symptoms (OCS) in schizophrenia patients is as around 30%. Evidence suggested that mild OCS could reduce symptoms of schizophrenia, supporting the presence of compensatory functions. However, severe OCS could aggravate various impairments in schizophrenia patients, supporting the "double jeopardy hypothesis". Patients with schizo-obsessive comorbidity, schizophrenia patients and obsessive-compulsive disorder patients have been found to have similarities in executive dysfunctions and altered resting-state functional connectivity within the executive control network (ECN). Executive functions could be associated with the ECN. However, little is known as to whether such overlap exists in the subclinical populations of individuals with schizo-obsessive traits (SOT), schizotypal individuals and individuals with high levels of obsessive-compulsive symptoms (OCS). In this study, we recruited 30 schizotypal individuals, 25 individuals with OCS, 29 individuals with SOT and 29 controls for a resting-state ECN-related functional connectivity (rsFC) and a go/shift/no-go task. We found that individuals with SOT exhibited increased rsFC within the ECN compared with controls, while schizotypal individuals exhibited the opposite. Individuals with OCS exhibited decreased rsFC within the ECN and between the ECN and the default mode network (DMN), relative to controls. No significant correlational results between altered rsFC related to the ECN with executive function performance were found after corrections for multiple comparisons in three subclinical groups. Our findings showed that individuals with SOT had increased rsFC within the ECN, while schizotypal individuals and individuals with OCS showed the opposite. Our findings provide evidence for possible neural substrates of subclinical comorbidity of OCS and schizotypy. CI - (c) 2021. Springer-Verlag GmbH, DE part of Springer Nature. FAU - Shan, Hai-Di AU - Shan HD AD - Translational Neuropsychology and Applied Cognitive Neuroscience Laboratory, Shanghai Mental Health Centre, Shanghai Jiao Tong University School of Medicine, 600 Wan Ping Nan Road, Shanghai, 200030, China. FAU - Wang, Yong-Ming AU - Wang YM AD - Neuropsychology and Applied Cognitive Neuroscience Laboratory, CAS Key Laboratory of Mental Health, Institute of Psychology, 16 Lincui Road, Beijing, 100101, China. AD - Department of Psychology, University of Chinese Academy of Sciences, Beijing, China. AD - Sino-Danish College, University of Chinese Academy of Sciences, Beijing, China. FAU - Hu, Hui-Xin AU - Hu HX AD - Translational Neuropsychology and Applied Cognitive Neuroscience Laboratory, Shanghai Mental Health Centre, Shanghai Jiao Tong University School of Medicine, 600 Wan Ping Nan Road, Shanghai, 200030, China. AD - Neuropsychology and Applied Cognitive Neuroscience Laboratory, CAS Key Laboratory of Mental Health, Institute of Psychology, 16 Lincui Road, Beijing, 100101, China. FAU - Jiang, Shu-Yao AU - Jiang SY AD - Translational Neuropsychology and Applied Cognitive Neuroscience Laboratory, Shanghai Mental Health Centre, Shanghai Jiao Tong University School of Medicine, 600 Wan Ping Nan Road, Shanghai, 200030, China. FAU - Chu, Min-Yi AU - Chu MY AD - Translational Neuropsychology and Applied Cognitive Neuroscience Laboratory, Shanghai Mental Health Centre, Shanghai Jiao Tong University School of Medicine, 600 Wan Ping Nan Road, Shanghai, 200030, China. FAU - Wang, Yi AU - Wang Y AD - Neuropsychology and Applied Cognitive Neuroscience Laboratory, CAS Key Laboratory of Mental Health, Institute of Psychology, 16 Lincui Road, Beijing, 100101, China. AD - Department of Psychology, University of Chinese Academy of Sciences, Beijing, China. FAU - Lui, Simon S Y AU - Lui SSY AD - Castle Peak Hospital, Hong Kong, China. AD - Department of Psychiatry, The University of Hong Kong, Hong Kong, China. FAU - Cheung, Eric F C AU - Cheung EFC AD - Castle Peak Hospital, Hong Kong, China. FAU - Wang, Zhen AU - Wang Z AD - Shanghai Mental Health Centre, Shanghai Jiao Tong University School of Medicine, Shanghai, China. AD - Institute of Psychological and Behavioural Science, Shanghai Jiao Tong University, Shanghai, China. AD - Shanghai Key Laboratory of Psychotic Disorders, Shanghai, China. FAU - Chan, Raymond C K AU - Chan RCK AUID- ORCID: 0000-0002-3414-450X AD - Translational Neuropsychology and Applied Cognitive Neuroscience Laboratory, Shanghai Mental Health Centre, Shanghai Jiao Tong University School of Medicine, 600 Wan Ping Nan Road, Shanghai, 200030, China. rckchan2003@yahoo.com.hk. AD - Neuropsychology and Applied Cognitive Neuroscience Laboratory, CAS Key Laboratory of Mental Health, Institute of Psychology, 16 Lincui Road, Beijing, 100101, China. rckchan2003@yahoo.com.hk. AD - Department of Psychology, University of Chinese Academy of Sciences, Beijing, China. rckchan2003@yahoo.com.hk. AD - Sino-Danish College, University of Chinese Academy of Sciences, Beijing, China. rckchan2003@yahoo.com.hk. LA - eng GR - 2016YFC0906402/National Key Research and Development Programme/ GR - SMHCRSD01/Science Foundation of Shanghai Mental Health Centre/ PT - Journal Article DEP - 20210103 PL - Germany TA - Eur Arch Psychiatry Clin Neurosci JT - European archives of psychiatry and clinical neuroscience JID - 9103030 SB - IM MH - Comorbidity MH - *Executive Function/physiology MH - Humans MH - *Obsessive-Compulsive Disorder/epidemiology/physiopathology MH - *Schizophrenia/epidemiology/physiopathology OTO - NOTNLM OT - Executive control network OT - Executive function OT - Obsessive-compulsive symptoms OT - Schizo-obsessive traits OT - Schizotypal traits EDAT- 2021/01/04 06:00 MHDA- 2022/03/15 06:00 CRDT- 2021/01/03 20:37 PHST- 2020/06/12 00:00 [received] PHST- 2020/12/12 00:00 [accepted] PHST- 2021/01/04 06:00 [pubmed] PHST- 2022/03/15 06:00 [medline] PHST- 2021/01/03 20:37 [entrez] AID - 10.1007/s00406-020-01222-y [pii] AID - 10.1007/s00406-020-01222-y [doi] PST - ppublish SO - Eur Arch Psychiatry Clin Neurosci. 2022 Mar;272(2):301-312. doi: 10.1007/s00406-020-01222-y. Epub 2021 Jan 3.