PMID- 33389127
OWN - NLM
STAT- MEDLINE
DCOM- 20210614
LR  - 20221207
IS  - 1432-5233 (Electronic)
IS  - 0940-5429 (Linking)
VI  - 58
IP  - 5
DP  - 2021 May
TI  - Type 2 diabetes mellitus and risk of head and neck cancer subtypes: a systematic 
      review and meta-analysis of observational studies.
PG  - 549-565
LID - 10.1007/s00592-020-01643-0 [doi]
AB  - AIMS: The association between type 2 diabetes mellitus (T2DM) and risk of head 
      and neck cancer (HNC) remains unclear. This study aims to perform a system review 
      and meta-analysis to explore this relationship. METHODS: PubMed, Web of Science, 
      and Embase databases were searched for studies published up to July 31, 2020, 
      regarding the association between T2DM and HNC risk. A random-effects model was 
      utilized to calculate summary relative risks (RRs) with corresponding 95% 
      confidence intervals (CIs). RESULTS: Fourteen case-control studies and thirteen 
      cohort studies were included in our analysis. We observed a weak association 
      between T2DM and risk of HNC overall, but there was no statistical significance 
      (RR, 1.04; 95% CI, 0.88-1.23; I(2) = 83.2%). Interestingly, there was a strong 
      association in East Asia (RR, 1.46; 95% CI, 1.21-1.77; I(2) = 36.6%). For HNC 
      subtypes, T2DM conferred a significantly elevated risk in oral cancer (RR, 1.22; 
      95% CI, 1.01-1.47; I(2) = 89.0%). However, in subgroup analyses of smoking, 
      alcohol use, and body mass index (BMI)/obesity adjustments, the association 
      between T2DM and oral cancer risk became insignificant. In addition, T2DM was not 
      associated with a statistically elevated risk of pharyngeal cancer (RR, 1.18; 95% 
      CI, 0.94-1.49; I(2) = 72.9%) and laryngeal cancer (RR, 1.03; 95% CI, 0.88-1.22; 
      I(2) = 71.2%). CONCLUSIONS: This meta-analysis indicates that T2DM is associated 
      with an increased risk of HNC in East Asia. As for site-specific cancer types, 
      the risk of oral cancer was significantly increased in T2DM patients, which 
      appear to be mediated or confounded by smoking, alcohol use, or BMI/obesity.
FAU - Yan, Pengfei
AU  - Yan P
AD  - Department of Preventive Medicine, School of Health Sciences, Wuhan University, 
      No. 185 Donghu Road, Wuhan, 430071, China.
FAU - Wang, Yongbo
AU  - Wang Y
AD  - Department of Preventive Medicine, School of Health Sciences, Wuhan University, 
      No. 185 Donghu Road, Wuhan, 430071, China.
AD  - Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan 
      University, Wuhan, 430071, China.
FAU - Yu, Xue
AU  - Yu X
AD  - Department of Preventive Medicine, School of Health Sciences, Wuhan University, 
      No. 185 Donghu Road, Wuhan, 430071, China.
FAU - Liu, Yu
AU  - Liu Y
AD  - Department of Statistics and Management, School of Management, Wuhan Institute of 
      Technology, Wuhan, 430205, China.
FAU - Zhang, Zhi-Jiang
AU  - Zhang ZJ
AUID- ORCID: 0000-0002-0119-7234
AD  - Department of Preventive Medicine, School of Health Sciences, Wuhan University, 
      No. 185 Donghu Road, Wuhan, 430071, China. zhang22968@163.com.
LA  - eng
GR  - 81641123/National Natural Science Foundation of China/
GR  - 2042017kf0193/Fundamental Research Funds for the Central Universities/
PT  - Journal Article
PT  - Meta-Analysis
PT  - Systematic Review
DEP - 20210103
PL  - Germany
TA  - Acta Diabetol
JT  - Acta diabetologica
JID - 9200299
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Body Mass Index
MH  - Case-Control Studies
MH  - Cohort Studies
MH  - Diabetes Mellitus, Type 2/complications/*epidemiology
MH  - Asia, Eastern/epidemiology
MH  - Female
MH  - Head and Neck Neoplasms/classification/complications/*epidemiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Obesity/complications/epidemiology
MH  - Observational Studies as Topic/statistics & numerical data
MH  - Risk
MH  - Risk Factors
OTO - NOTNLM
OT  - Head and neck cancer
OT  - Laryngeal cancer
OT  - Oral cancer
OT  - Pharyngeal cancer
OT  - Risk
OT  - Type 2 diabetes mellitus
EDAT- 2021/01/04 06:00
MHDA- 2021/06/16 06:00
CRDT- 2021/01/03 20:37
PHST- 2020/09/13 00:00 [received]
PHST- 2020/11/20 00:00 [accepted]
PHST- 2021/01/04 06:00 [pubmed]
PHST- 2021/06/16 06:00 [medline]
PHST- 2021/01/03 20:37 [entrez]
AID - 10.1007/s00592-020-01643-0 [pii]
AID - 10.1007/s00592-020-01643-0 [doi]
PST - ppublish
SO  - Acta Diabetol. 2021 May;58(5):549-565. doi: 10.1007/s00592-020-01643-0. Epub 2021 
      Jan 3.