PMID- 33389155
OWN - NLM
STAT- MEDLINE
DCOM- 20211115
LR  - 20211115
IS  - 1436-5073 (Electronic)
IS  - 0026-3672 (Linking)
VI  - 188
IP  - 1
DP  - 2021 Jan 2
TI  - Hybrid MoS(2)/g-C(3)N(4)-assisted LDI mass spectrometry for rapid detection of 
      small molecules and polyethylene glycols and direct determination of uric acid in 
      complicated biological samples.
PG  - 5
LID - 10.1007/s00604-020-04675-z [doi]
AB  - A novel matrix-assisted laser desorption/ionization time-of-flight mass 
      spectrometric method (MALDI-TOF MS) for determination of highly sensitive small 
      molecular compounds was developed based on molybdenum disulfide nanosheets 
      hybridized with ultrathin graphitic carbon nitride (MoS(2)/g-C(3)N(4)) as the 
      matrix. With this approach, the synergistic effects of MoS(2) and g-C(3)N(4) 
      enhance the UV absorption of MoS(2)/g-C(3)N(4), increase both desorption and 
      ionization efficiency in LDI MS, and induce higher signal-to-noise ratio of 
      analytes when compared with the bare MoS(2) and g-C(3)N(4) matrix in the 
      determination of amino acids, antibiotics, neutral oligosaccharides, uric acid, 
      and polyethylene glycols (PEGs). The detection limits of these small molecular 
      compounds are in the ranges 0.1 to 10 mug mL(-1), 1*10(-3) to 1.0 mug mL(-1), 1.0 
      to 10 mug mL(-1), and 2*10(-4) mug mL(-1), respectively, and the polydispersity 
      index of these PEGs is less than 1.02. Moreover, high salt tolera;nce and 
      homogeneous deposition on the spot results in good reproducibility. The relative 
      standard deviations (RSDs) of shot-to-shot and spot-to-spot (n = 15) of these 
      compounds are less than 10.1% and 12.5%, respectively. With MoS(2)/g-C(3)N(4), 
      the uric acid in complicated biological samples can be directly determined in 
      combination with LDI-TOF MS. We synthesized MoS(2)/g-C(3)N(4) nanohybrid as an 
      efficient matrix for MALDI-TOF MS analysis of small molecules as well as 
      quantitative detection of uric acid in human urine.
FAU - Lv, Yuanxia
AU  - Lv Y
AD  - State Key Laboratory for Chemistry and Molecular Engineering of Medicinal 
      Resources, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal 
      University, Guilin, 541004, People's Republic of China.
FAU - Qin, Xiaohuan
AU  - Qin X
AD  - State Key Laboratory for Chemistry and Molecular Engineering of Medicinal 
      Resources, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal 
      University, Guilin, 541004, People's Republic of China.
FAU - Hu, Kun
AU  - Hu K
AUID- ORCID: 0000-0003-4420-2467
AD  - State Key Laboratory for Chemistry and Molecular Engineering of Medicinal 
      Resources, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal 
      University, Guilin, 541004, People's Republic of China. hukun216@163.com.
FAU - Huang, Yong
AU  - Huang Y
AD  - State Key Laboratory for Chemistry and Molecular Engineering of Medicinal 
      Resources, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal 
      University, Guilin, 541004, People's Republic of China.
FAU - Zhao, Shulin
AU  - Zhao S
AD  - State Key Laboratory for Chemistry and Molecular Engineering of Medicinal 
      Resources, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal 
      University, Guilin, 541004, People's Republic of China.
LA  - eng
GR  - 21565007/National Natural Science Foundation of China/
GR  - 22064002/National Natural Science Foundation of China/
GR  - 2020GXNSFAA238038/Natural Science Foundation of Guangxi Province/
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210102
PL  - Austria
TA  - Mikrochim Acta
JT  - Mikrochimica acta
JID - 7808782
RN  - 0 (Amino Acids)
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Cyclodextrins)
RN  - 0 (Disulfides)
RN  - 0 (Nitrogen Compounds)
RN  - 0 (graphitic carbon nitride)
RN  - 268B43MJ25 (Uric Acid)
RN  - 3WJQ0SDW1A (Polyethylene Glycols)
RN  - 7782-42-5 (Graphite)
RN  - 81AH48963U (Molybdenum)
RN  - ZC8B4P503V (molybdenum disulfide)
SB  - IM
MH  - Amino Acids/analysis
MH  - Anti-Bacterial Agents/analysis
MH  - Cyclodextrins/analysis
MH  - Disulfides/*chemistry
MH  - Graphite/*chemistry
MH  - Humans
MH  - Limit of Detection
MH  - Mass Spectrometry/*methods
MH  - Molybdenum/*chemistry
MH  - Nanostructures/*chemistry
MH  - Nitrogen Compounds/*chemistry
MH  - Polyethylene Glycols/analysis
MH  - Reproducibility of Results
MH  - Uric Acid/*urine
OTO - NOTNLM
OT  - Complex matrix analysis
OT  - Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry
OT  - MoS2/g-C3N4
OT  - Small molecule determination
EDAT- 2021/01/04 06:00
MHDA- 2021/11/16 06:00
CRDT- 2021/01/03 20:38
PHST- 2020/09/10 00:00 [received]
PHST- 2020/11/30 00:00 [accepted]
PHST- 2021/01/03 20:38 [entrez]
PHST- 2021/01/04 06:00 [pubmed]
PHST- 2021/11/16 06:00 [medline]
AID - 10.1007/s00604-020-04675-z [pii]
AID - 10.1007/s00604-020-04675-z [doi]
PST - epublish
SO  - Mikrochim Acta. 2021 Jan 2;188(1):5. doi: 10.1007/s00604-020-04675-z.