PMID- 33389491
OWN - NLM
STAT- MEDLINE
DCOM- 20210802
LR  - 20210802
IS  - 1573-4919 (Electronic)
IS  - 0300-8177 (Linking)
VI  - 476
IP  - 3
DP  - 2021 Mar
TI  - Dysfunction of chaperone-mediated autophagy in human diseases.
PG  - 1439-1454
LID - 10.1007/s11010-020-04006-z [doi]
AB  - Chaperone-mediated autophagy (CMA), one of the degradation pathways of proteins, 
      is highly selective to substrates that have KFERQ-like motif. In this process, 
      the substrate proteins are first recognized by the chaperone protein, heat shock 
      cognate protein 70 (Hsc70), then delivered to lysosomal membrane surface where 
      the single-span lysosomal receptor, lysosome-associated membrane protein type 2A 
      (LAMP2A) can bind to the substrate proteins to form a 700 kDa protein complex 
      that allows them to translocate into the lysosome lumen to be degraded by the 
      hydrolytic enzymes. This degradation pathway mediated by CMA plays an important 
      role in regulating glucose and lipid metabolism, transcription, DNA reparation, 
      cell cycle, cellular response to stress and consequently, regulating many 
      aging-associated human diseases, such as neurodegeneration, cancer and metabolic 
      disorders. In this review, we provide an overview of current research on the 
      functional roles of CMA primarily from a perspective of understanding and 
      treating human diseases and also discuss its potential applications for diseases.
FAU - Liao, Zhaozhong
AU  - Liao Z
AD  - Department of Biochemistry and Molecular Biology, School of Basic Medicine, 
      Qingdao University, Qingdao, China.
FAU - Wang, Bin
AU  - Wang B
AD  - College of Electronic Information, Micro-Nano Technology College, Qingdao 
      University, Qingdao, China.
FAU - Liu, Wenjing
AU  - Liu W
AD  - Department of Biochemistry and Molecular Biology, School of Basic Medicine, 
      Qingdao University, Qingdao, China.
FAU - Xu, Qian
AU  - Xu Q
AD  - Department of Biochemistry and Molecular Biology, School of Basic Medicine, 
      Qingdao University, Qingdao, China.
FAU - Hou, Lin
AU  - Hou L
AD  - Department of Biochemistry and Molecular Biology, School of Basic Medicine, 
      Qingdao University, Qingdao, China.
FAU - Song, Jinlian
AU  - Song J
AD  - Department of Laboratory, The Affiliated Women and Children's Hospital of Qingdao 
      University, Qingdao University, Qingdao, China.
FAU - Guo, Qingming
AU  - Guo Q
AD  - Biotherapy Center, Clinical Laboratory, Qingdao Central Hospital, The Second 
      Affiliated Hospital of Qingdao University, Qingdao, China.
FAU - Li, Ning
AU  - Li N
AUID- ORCID: 0000-0002-1895-4983
AD  - Department of Biochemistry and Molecular Biology, School of Basic Medicine, 
      Qingdao University, Qingdao, China. ning-99@163.com.
LA  - eng
GR  - 81600470/National Natural Science Foundation of China/
GR  - 19-6-2-59-cg/Qingdao Applied Basic Research Youth Project/
GR  - 2015M57074,2016T90612/China Postdoctoral Science Foundation Funded Project/
PT  - Journal Article
PT  - Review
DEP - 20210103
PL  - Netherlands
TA  - Mol Cell Biochem
JT  - Molecular and cellular biochemistry
JID - 0364456
RN  - 0 (HSC70 Heat-Shock Proteins)
RN  - 0 (Lysosomal-Associated Membrane Protein 2)
RN  - 0 (Molecular Chaperones)
SB  - IM
MH  - Aging
MH  - Alzheimer Disease/metabolism
MH  - Amino Acid Motifs
MH  - Amyotrophic Lateral Sclerosis/metabolism
MH  - Animals
MH  - *Autophagy
MH  - *Chaperone-Mediated Autophagy
MH  - HSC70 Heat-Shock Proteins/*metabolism
MH  - Homeostasis
MH  - Humans
MH  - Huntington Disease/metabolism
MH  - Hydrolysis
MH  - Lysosomal-Associated Membrane Protein 2/metabolism
MH  - Lysosomes/*metabolism
MH  - Molecular Chaperones/*metabolism
MH  - Neoplasms/metabolism
MH  - Neurodegenerative Diseases
MH  - Parkinson Disease/metabolism
MH  - Protein Processing, Post-Translational
MH  - T-Lymphocytes/metabolism
OTO - NOTNLM
OT  - Cancer
OT  - Chaperone-mediated autophagy
OT  - KFERQ-like motif
OT  - Metabolic disorder
OT  - Neurodegenerative diseases
EDAT- 2021/01/04 06:00
MHDA- 2021/08/03 06:00
CRDT- 2021/01/03 20:40
PHST- 2020/08/17 00:00 [received]
PHST- 2020/11/24 00:00 [accepted]
PHST- 2021/01/04 06:00 [pubmed]
PHST- 2021/08/03 06:00 [medline]
PHST- 2021/01/03 20:40 [entrez]
AID - 10.1007/s11010-020-04006-z [pii]
AID - 10.1007/s11010-020-04006-z [doi]
PST - ppublish
SO  - Mol Cell Biochem. 2021 Mar;476(3):1439-1454. doi: 10.1007/s11010-020-04006-z. 
      Epub 2021 Jan 3.