PMID- 33389780
OWN - NLM
STAT- MEDLINE
DCOM- 20211207
LR  - 20221005
IS  - 1755-5949 (Electronic)
IS  - 1755-5930 (Print)
IS  - 1755-5930 (Linking)
VI  - 27
IP  - 1
DP  - 2021 Jan
TI  - Neurovascular Unit: A critical role in ischemic stroke.
PG  - 7-16
LID - 10.1111/cns.13561 [doi]
AB  - Ischemic stroke (IS), a common cerebrovascular disease, results from a sudden 
      blockage of a blood vessel in the brain, thereby restricting blood supply to the 
      area in question, and making a significantly negative impact on human health. 
      Unfortunately, current treatments, that are mainly based on a recanalization of 
      occluded blood vessels, are insufficient or inaccessible to many stroke patients. 
      Recently, the profound influence of the neurovascular unit (NVU) on 
      recanalization and the prognosis of IS have become better understood; in-depth 
      studies of the NVU have also provided novel approaches for IS treatment. In this 
      article, we review the intimate connections between the changes in the NVU and IS 
      outcomes, and discuss possible new management strategies having practical 
      significance to IS. We discuss the concept of the NVU, as well as its roles in IS 
      blood-brain barrier regulation, cell preservation, inflammatory immune response, 
      and neurovascular repair. Besides, we also summarize the influence of noncoding 
      RNAs in NVU, and IS therapies targeting the NVU. We conclude that both the 
      pathophysiological and neurovascular repair processes of IS are strongly 
      associated with the homeostatic state of the NVU and that further research into 
      therapies directed at the NVU could expand the range of treatments available for 
      IS.
CI  - (c) 2021 The Authors. CNS Neuroscience & Therapeutics Published by John Wiley & 
      Sons Ltd.
FAU - Wang, Liyun
AU  - Wang L
AUID- ORCID: 0000-0001-7608-3787
AD  - Department of Neurosurgery, Shengzhou People's Hospital (the First Affiliated 
      Hospital of Zhejiang University Shengzhou Branch), Shengzhou, China.
FAU - Xiong, Xiaoxing
AU  - Xiong X
AD  - Department of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan, China.
FAU - Zhang, Luyuan
AU  - Zhang L
AD  - Department of Neurosurgery, First Affiliated Hospital, School of Medicine, 
      Zhejiang University, Hangzhou, China.
FAU - Shen, Jian
AU  - Shen J
AD  - Department of Neurosurgery, First Affiliated Hospital, School of Medicine, 
      Zhejiang University, Hangzhou, China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20210102
PL  - England
TA  - CNS Neurosci Ther
JT  - CNS neuroscience & therapeutics
JID - 101473265
SB  - IM
MH  - Animals
MH  - Blood-Brain Barrier/immunology/*physiopathology
MH  - Brain/immunology/physiopathology
MH  - Brain Ischemia/immunology/*physiopathology/therapy
MH  - Cell- and Tissue-Based Therapy/methods/trends
MH  - Humans
MH  - Immunity/physiology
MH  - Ischemic Stroke/immunology/*physiopathology/therapy
MH  - Neurons/*physiology
MH  - Neurovascular Coupling/*physiology
PMC - PMC7804897
OTO - NOTNLM
OT  - Ischemia
OT  - MicroRNAs
OT  - Neurovascular unit
OT  - Stroke
OT  - Therapy
COIS- The authors declare no conflict of interest.
EDAT- 2021/01/04 06:00
MHDA- 2021/12/15 06:00
PMCR- 2021/01/02
CRDT- 2021/01/03 20:43
PHST- 2020/09/22 00:00 [received]
PHST- 2020/11/23 00:00 [revised]
PHST- 2020/11/24 00:00 [accepted]
PHST- 2021/01/04 06:00 [pubmed]
PHST- 2021/12/15 06:00 [medline]
PHST- 2021/01/03 20:43 [entrez]
PHST- 2021/01/02 00:00 [pmc-release]
AID - CNS13561 [pii]
AID - 10.1111/cns.13561 [doi]
PST - ppublish
SO  - CNS Neurosci Ther. 2021 Jan;27(1):7-16. doi: 10.1111/cns.13561. Epub 2021 Jan 2.