PMID- 33389971
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210111
IS  - 2508-4909 (Electronic)
IS  - 2508-4798 (Print)
IS  - 2508-4798 (Linking)
VI  - 24
IP  - 4
DP  - 2020 Dec
TI  - The Discovery of Druggable Anti-aging Agents.
PG  - 232-242
LID - 10.4235/agmr.20.0092 [doi]
AB  - Caloric restriction (CR) has been shown to extend the lifespan of many species. 
      Research to identify compounds that imitate the results of CR has shown 
      extensions of both lifespan and healthspan via different mechanisms. For example, 
      mechanistic target of rapamycin (mTOR) inhibitors such as rapamycin, phenols, and 
      flavonoids show antioxidant characteristics, while spermidine induces autophagy. 
      Herein, we summarize research progress and proposed mechanisms for the most 
      well-known compounds showing lifespan-extending potential for anti-aging 
      characteristics.
FAU - Yalcin, Gulperi
AU  - Yalcin G
AD  - Department of Biotechnology, College of Life Sciences and Biotechnology, Korea 
      University, Seoul, Korea.
FAU - Lee, Cheol-Koo
AU  - Lee CK
AD  - Department of Biotechnology, College of Life Sciences and Biotechnology, Korea 
      University, Seoul, Korea.
LA  - eng
PT  - Journal Article
DEP - 20201229
PL  - Korea (South)
TA  - Ann Geriatr Med Res
JT  - Annals of geriatric medicine and research
JID - 101701105
PMC - PMC7781965
OTO - NOTNLM
OT  - Anti-aging
OT  - Lifespan extension
OT  - Caloric restriction mimetics
COIS- CONFLICT OF INTEREST The researchers claim no conflicts of interest.
EDAT- 2021/01/05 06:00
MHDA- 2021/01/05 06:01
PMCR- 2020/12/01
CRDT- 2021/01/04 03:22
PHST- 2020/12/09 00:00 [received]
PHST- 2020/12/10 00:00 [accepted]
PHST- 2021/01/04 03:22 [entrez]
PHST- 2021/01/05 06:00 [pubmed]
PHST- 2021/01/05 06:01 [medline]
PHST- 2020/12/01 00:00 [pmc-release]
AID - agmr.20.0092 [pii]
AID - agmr-20-0092 [pii]
AID - 10.4235/agmr.20.0092 [doi]
PST - ppublish
SO  - Ann Geriatr Med Res. 2020 Dec;24(4):232-242. doi: 10.4235/agmr.20.0092. Epub 2020 
      Dec 29.