PMID- 33390452
OWN - NLM
STAT- MEDLINE
DCOM- 20210215
LR  - 20210215
IS  - 1347-5231 (Electronic)
IS  - 0031-6903 (Linking)
VI  - 141
IP  - 1
DP  - 2021
TI  - [Effects of Histamine and Related Compounds on the Central Nervous System].
PG  - 93-110
LID - 10.1248/yakushi.20-00197 [doi]
AB  - There has been little information about the role of histamine on the central 
      nervous system (CNS), different from dopamine and serotonin. In the present 
      study, therefore, the effects of histamine and related compounds on the CNS were 
      studied using rats. Intracerebroventricular (i.c.v.) injection of histamine and 
      2-methylhistamine ameliorated memory deficit after long interrution of learning 
      in active avoidance response. First generation H(1)-antagonists inhibited active 
      avoidance response, whereas newly develpoed H(1)-antagonists showed little 
      effect. alpha-Fluoromethylhistidine, an histidine decarboxylase inhibitor, also 
      inhibited active avoidance response. In radial maze performance, almost the same 
      findings were obtained. I.c.v. injection of histamine and H(1)-agonists inhibited 
      amygdaloid kindled seizures. First generation H(1)-antagonists attenuated 
      histamine-induced inhibition of amygdaloid kindled seizures. Both i.c.v. and 
      intraperitoneal injections of H(3)-antagonist, thioperamide, resulted in a 
      dose-related inhibition of amygdaloid kindled seizures. The effect of 
      thioperamide was inhibited by an H(3)-agonists and H(1)-antagonists. Similar to 
      nitrazepam, diphenhydramine and chlorpheniramine caused a shortening of sleep 
      latency. On the other hand, no significant effects were observed with second 
      generation H(1)-antagonists. These findings suggest that histamine plays an 
      important role in learning and memory via H(1)-receptors, an inhibition of 
      amygdaloid kindled seizures induced by histamine occurred through not only 
      H(1)-receptors but also H(3)-receptors, and that classic H(1)-antagonists can be 
      useful as a effective hypnotic for difficulty in falling asleep.
FAU - Kamei, Chiaki
AU  - Kamei C
AD  - Department of Pharmacology, Faculty of Pharmaceutical Sciences, Yasuda Women's 
      University.
AD  - Department of Medicinal Pharmacology, Graduate School of Medicine Dentistry and 
      Pharmaceutical Sciences, Okayama University.
LA  - jpn
PT  - Journal Article
PT  - Review
PL  - Japan
TA  - Yakugaku Zasshi
JT  - Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
JID - 0413613
RN  - 0 (Histamine H1 Antagonists)
RN  - 0 (Hypnotics and Sedatives)
RN  - 0 (Methylhistamines)
RN  - 0 (Methylhistidines)
RN  - 0 (Receptors, Histamine H3)
RN  - 70050-43-0 (alpha-fluoromethylhistidine)
RN  - 820484N8I3 (Histamine)
RN  - H5DHG2WBHM (2-methylhistamine)
SB  - IM
MH  - Animals
MH  - Avoidance Learning/drug effects
MH  - Central Nervous System/*drug effects
MH  - Histamine/administration & dosage/metabolism/*pharmacology/physiology
MH  - Histamine H1 Antagonists/*pharmacology/therapeutic use
MH  - Humans
MH  - Hypnotics and Sedatives
MH  - Injections, Intraventricular
MH  - Kindling, Neurologic/drug effects
MH  - Memory Disorders/drug therapy
MH  - Methylhistamines/administration & dosage/*pharmacology
MH  - Methylhistidines/administration & dosage/*pharmacology
MH  - Mice
MH  - Rats
MH  - Receptors, Histamine H3/metabolism/physiology
MH  - Seizures/drug therapy
MH  - Sleep/drug effects
MH  - Sleep Initiation and Maintenance Disorders/drug therapy
OTO - NOTNLM
OT  - amygdaloid kindking
OT  - histamine
OT  - histamine agonist
OT  - histamine antagonist
OT  - learning behavior
OT  - sleep-wake cycle
EDAT- 2021/01/05 06:00
MHDA- 2021/02/16 06:00
CRDT- 2021/01/04 05:24
PHST- 2021/01/04 05:24 [entrez]
PHST- 2021/01/05 06:00 [pubmed]
PHST- 2021/02/16 06:00 [medline]
AID - 10.1248/yakushi.20-00197 [doi]
PST - ppublish
SO  - Yakugaku Zasshi. 2021;141(1):93-110. doi: 10.1248/yakushi.20-00197.