PMID- 33390654
OWN - NLM
STAT- MEDLINE
DCOM- 20210811
LR  - 20240229
IS  - 1928-9022 (Electronic)
IS  - 0830-9000 (Print)
IS  - 0830-9000 (Linking)
VI  - 85
IP  - 1
DP  - 2021 Jan
TI  - Treatment of naturally occurring asthma with inhaled fluticasone or oral 
      prednisolone: A randomized pilot trial.
PG  - 61-67
AB  - The objective of this study was to compare inhaled glucocorticoids with oral 
      glucocorticoids for treatment of naturally occurring feline asthma. Secondary 
      goals were to evaluate serum allergy testing results in cats and to quantify the 
      effect of an inhaled glucocorticoid (fluticasone) on glucose homeostasis. Nine 
      cats with asthma were enrolled on the basis of clinical signs, thoracic 
      radiographic findings, and airway eosinophilia. Cats were randomized and 4 cats 
      were treated with oral glucocorticoids and 5 cats with inhaled glucocorticoids, 
      with a 7-day course of oral glucocorticoids overlapping at the start of therapy. 
      Cats were evaluated at baseline and at 8 wk with thoracic radiographs, 
      bronchoalveolar lavage, lung function testing, and fructosamine levels. Serum 
      allergen panels were evaluated. All cats were clinically normal after treatment 
      and had significantly improved airway eosinophilia and decreased nucleated cell 
      count. No improvement was seen in radiographic changes after treatment with 
      either therapy. Oral, but not inhaled glucocorticoids, caused a decrease in 
      airway resistance, although cats in the inhaled group had a higher baseline 
      resistance than those in the oral group. Fructosamine levels did not change with 
      treatment. Fifty percent of cats tested positive for immunoglobulin E (IgE) 
      antibodies. Asthma is a heterogeneous condition; individual cats responded well 
      to both oral and inhaled glucocorticoids. Ongoing evaluation of the potential 
      underlying causes and therapeutic options is warranted with a larger group of 
      cats.
CI  - Copyright and/or publishing rights held by the Canadian Veterinary Medical 
      Association.
FAU - Verschoor-Kirss, Michael
AU  - Verschoor-Kirss M
AD  - Department of Clinical Sciences (Verschoor-Kirss, Rozanski, Sharp, Oura, Egan) 
      and Department of Biomedical Sciences (Bain, Knoll), Cummings School of 
      Veterinary Medicine, Tufts University, 200 Westboro Road, North Grafton, 
      Massachusetts 01536, USA.
FAU - Rozanski, Elizabeth A
AU  - Rozanski EA
AD  - Department of Clinical Sciences (Verschoor-Kirss, Rozanski, Sharp, Oura, Egan) 
      and Department of Biomedical Sciences (Bain, Knoll), Cummings School of 
      Veterinary Medicine, Tufts University, 200 Westboro Road, North Grafton, 
      Massachusetts 01536, USA.
FAU - Sharp, Claire R
AU  - Sharp CR
AD  - Department of Clinical Sciences (Verschoor-Kirss, Rozanski, Sharp, Oura, Egan) 
      and Department of Biomedical Sciences (Bain, Knoll), Cummings School of 
      Veterinary Medicine, Tufts University, 200 Westboro Road, North Grafton, 
      Massachusetts 01536, USA.
FAU - Oura, Trisha J
AU  - Oura TJ
AD  - Department of Clinical Sciences (Verschoor-Kirss, Rozanski, Sharp, Oura, Egan) 
      and Department of Biomedical Sciences (Bain, Knoll), Cummings School of 
      Veterinary Medicine, Tufts University, 200 Westboro Road, North Grafton, 
      Massachusetts 01536, USA.
FAU - Egan, Ashley
AU  - Egan A
AD  - Department of Clinical Sciences (Verschoor-Kirss, Rozanski, Sharp, Oura, Egan) 
      and Department of Biomedical Sciences (Bain, Knoll), Cummings School of 
      Veterinary Medicine, Tufts University, 200 Westboro Road, North Grafton, 
      Massachusetts 01536, USA.
FAU - Bain, Perry
AU  - Bain P
AD  - Department of Clinical Sciences (Verschoor-Kirss, Rozanski, Sharp, Oura, Egan) 
      and Department of Biomedical Sciences (Bain, Knoll), Cummings School of 
      Veterinary Medicine, Tufts University, 200 Westboro Road, North Grafton, 
      Massachusetts 01536, USA.
FAU - Knoll, Joyce
AU  - Knoll J
AD  - Department of Clinical Sciences (Verschoor-Kirss, Rozanski, Sharp, Oura, Egan) 
      and Department of Biomedical Sciences (Bain, Knoll), Cummings School of 
      Veterinary Medicine, Tufts University, 200 Westboro Road, North Grafton, 
      Massachusetts 01536, USA.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial, Veterinary
PL  - Canada
TA  - Can J Vet Res
JT  - Canadian journal of veterinary research = Revue canadienne de recherche 
      veterinaire
JID - 8607793
RN  - CUT2W21N7U (Fluticasone)
RN  - 9PHQ9Y1OLM (Prednisolone)
SB  - IM
MH  - Animals
MH  - Cats
MH  - Female
MH  - Male
MH  - Administration, Inhalation
MH  - Administration, Oral
MH  - *Asthma/drug therapy/veterinary
MH  - *Cat Diseases/drug therapy
MH  - *Fluticasone/administration & dosage/therapeutic use
MH  - Pilot Projects
MH  - *Prednisolone/administration & dosage/therapeutic use
PMC - PMC7747657
EDAT- 2021/01/05 06:00
MHDA- 2021/08/11 06:00
PMCR- 2021/07/01
CRDT- 2021/01/04 05:24
PHST- 2020/03/07 00:00 [received]
PHST- 2020/06/21 00:00 [accepted]
PHST- 2021/01/04 05:24 [entrez]
PHST- 2021/01/05 06:00 [pubmed]
PHST- 2021/08/11 06:00 [medline]
PHST- 2021/07/01 00:00 [pmc-release]
AID - cjvr_01_61 [pii]
PST - ppublish
SO  - Can J Vet Res. 2021 Jan;85(1):61-67.