PMID- 33390905
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210105
IS  - 1662-5102 (Print)
IS  - 1662-5102 (Electronic)
IS  - 1662-5102 (Linking)
VI  - 14
DP  - 2020
TI  - Pregnancy Changes the Response of the Vomeronasal and Olfactory Systems to Pups 
      in Mice.
PG  - 593309
LID - 10.3389/fncel.2020.593309 [doi]
LID - 593309
AB  - Motherhood entails changes in behavior with increased motivation for pups, 
      induced in part by pregnancy hormones acting upon the brain. This work explores 
      whether this alters sensory processing of pup-derived chemosignals. To do so, we 
      analyse the expression of immediate early genes (IEGs) in the vomeronasal organ 
      (VNO; Egr1) and centers of the olfactory and vomeronasal brain pathways (cFos) in 
      virgin and late-pregnant females exposed to pups, as compared to buttons 
      (socially neutral control). In pup-exposed females, we quantified diverse 
      behaviors including pup retrieval, sniffing, pup-directed attack, nest building 
      and time in nest or on nest, as well as time off nest. Pups induce Egr1 
      expression in the VNO of females, irrespective of their physiological condition, 
      thus suggesting the existence of VNO-detected pup chemosignals. A similar 
      situation is found in the accessory olfactory bulb (AOB) and posteromedial part 
      of the medial bed nucleus of the stria terminalis (BSTMPM). By contrast, in the 
      medial amygdala and posteromedial cortical amygdala (PMCo), responses to 
      pups-vs-buttons are different in virgin and late-pregnant females, thus 
      suggesting altered sensory processing during late pregnancy. The olfactory system 
      also shows changes in sensory processing with pregnancy. In the main olfactory 
      bulbs, as well as the anterior and posterior piriform cortex, buttons activate 
      cFos expression in virgins more than in pregnant females. By contrast, in the 
      anterior and especially posterior piriform cortex, pregnant females show more 
      activation by pups than buttons. Correlation between IEGs expression and behavior 
      suggests the existence of two vomeronasal subsystems: one associated to pup care 
      (with PMCo as its main center) and another related to pup-directed aggression 
      observed in some pregnant females (with the BSTMPM as the main nucleus). Our data 
      also suggest a coactivation of the olfactory and vomeronasal systems during 
      interaction with pups in pregnant females.
CI  - Copyright (c) 2020 Navarro-Moreno, Sanchez-Catalan, Barneo-Munoz, 
      Goterris-Cerisuelo, Belles, Lanuza, Agustin-Pavon and Martinez-Garcia.
FAU - Navarro-Moreno, Cinta
AU  - Navarro-Moreno C
AD  - Lab of Functional Neuroanatomy (NeuroFun-UJI-UV), Unitat Predepartamental de 
      Medicina, Faculty of Health Sciences, Universitat Jaume I, Castellon de la Plana, 
      Spain.
FAU - Sanchez-Catalan, Maria Jose
AU  - Sanchez-Catalan MJ
AD  - Lab of Functional Neuroanatomy (NeuroFun-UJI-UV), Unitat Predepartamental de 
      Medicina, Faculty of Health Sciences, Universitat Jaume I, Castellon de la Plana, 
      Spain.
FAU - Barneo-Munoz, Manuela
AU  - Barneo-Munoz M
AD  - Lab of Functional Neuroanatomy (NeuroFun-UJI-UV), Unitat Predepartamental de 
      Medicina, Faculty of Health Sciences, Universitat Jaume I, Castellon de la Plana, 
      Spain.
FAU - Goterris-Cerisuelo, Rafael
AU  - Goterris-Cerisuelo R
AD  - Lab of Functional Neuroanatomy (NeuroFun-UJI-UV), Unitat Predepartamental de 
      Medicina, Faculty of Health Sciences, Universitat Jaume I, Castellon de la Plana, 
      Spain.
FAU - Belles, Maria
AU  - Belles M
AD  - Lab of Functional Neuroanatomy (NeuroFun-UJI-UV), Unitat Predepartamental de 
      Medicina, Faculty of Health Sciences, Universitat Jaume I, Castellon de la Plana, 
      Spain.
FAU - Lanuza, Enrique
AU  - Lanuza E
AD  - Lab of Functional Neuroanatomy (NeuroFun-UJI-UV), Departament de Biologia 
      Cellular, Funcional i Antropologia, Faculty of Biological Sciences, Universitat 
      de Valencia, Valencia, Spain.
FAU - Agustin-Pavon, Carmen
AU  - Agustin-Pavon C
AD  - Lab of Functional Neuroanatomy (NeuroFun-UJI-UV), Departament de Biologia 
      Cellular, Funcional i Antropologia, Faculty of Biological Sciences, Universitat 
      de Valencia, Valencia, Spain.
FAU - Martinez-Garcia, Fernando
AU  - Martinez-Garcia F
AD  - Lab of Functional Neuroanatomy (NeuroFun-UJI-UV), Unitat Predepartamental de 
      Medicina, Faculty of Health Sciences, Universitat Jaume I, Castellon de la Plana, 
      Spain.
LA  - eng
PT  - Journal Article
DEP - 20201218
PL  - Switzerland
TA  - Front Cell Neurosci
JT  - Frontiers in cellular neuroscience
JID - 101477935
PMC - PMC7775479
OTO - NOTNLM
OT  - IEGs
OT  - mice
OT  - olfactory system
OT  - pregnancy
OT  - pup chemosignals
OT  - vomeronasal system
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/01/05 06:00
MHDA- 2021/01/05 06:01
PMCR- 2020/01/01
CRDT- 2021/01/04 05:25
PHST- 2020/08/10 00:00 [received]
PHST- 2020/11/16 00:00 [accepted]
PHST- 2021/01/04 05:25 [entrez]
PHST- 2021/01/05 06:00 [pubmed]
PHST- 2021/01/05 06:01 [medline]
PHST- 2020/01/01 00:00 [pmc-release]
AID - 10.3389/fncel.2020.593309 [doi]
PST - epublish
SO  - Front Cell Neurosci. 2020 Dec 18;14:593309. doi: 10.3389/fncel.2020.593309. 
      eCollection 2020.