PMID- 3339099
OWN - NLM
STAT- MEDLINE
DCOM- 19880307
LR  - 20131121
IS  - 0271-678X (Print)
IS  - 0271-678X (Linking)
VI  - 8
IP  - 1
DP  - 1988 Feb
TI  - Free radical reaction and biological defense mechanism in the pathogenesis of 
      prolonged vasospasm in experimental subarachnoid hemorrhage.
PG  - 1-8
AB  - The relationship between free radical reactions and the defense mechanisms 
      against them was investigated in the pathogenesis of prolonged vasospasm 
      following experimental subarachnoid hemorrhage (SAH) in dogs. The concentration 
      of lipid peroxides in the cerebro spinal fluid (CSF) increased markedly up to the 
      eighth day following SAH; the concentrations also rose in the arterial wall (p 
      less than 0.01) and the gray matter of the temporal lobe where the subarachnoid 
      blood clots were (p less than 0.01). On the other hand, the activity of 
      superoxide dismutase (SOD) decreased significantly up to the eighth day after SAH 
      (p less than 0.01), and there was a gradual increase of glutathione peroxidase 
      (GSH-px) in the CSF. In the arterial wall, there was a slight decrease in the 
      activity of SOD, a significant decrease in the activity of GSH-px (p less than 
      0.01), and also a significant decrease in the concentration of glutathione (p 
      less than 0.01) up to the eighth day following SAH. In conclusion, lipid 
      peroxidation with insufficient biological defense mechanisms against it in the 
      arterial wall, concomitant with that in the CSF, might take part in the genesis 
      of prolonged vasospasm following SAH.
FAU - Sakaki, S
AU  - Sakaki S
AD  - Department of Neurological Surgery, Ehime University School of Medicine, Japan.
FAU - Ohta, S
AU  - Ohta S
FAU - Nakamura, H
AU  - Nakamura H
FAU - Takeda, S
AU  - Takeda S
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Cereb Blood Flow Metab
JT  - Journal of cerebral blood flow and metabolism : official journal of the 
      International Society of Cerebral Blood Flow and Metabolism
JID - 8112566
RN  - 0 (Free Radicals)
RN  - 0 (Lipid Peroxides)
RN  - EC 1.11.1.9 (Glutathione Peroxidase)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - GAN16C9B8O (Glutathione)
SB  - IM
MH  - Animals
MH  - Basilar Artery/pathology
MH  - Brain/metabolism
MH  - Cerebral Arteries/metabolism
MH  - Dogs
MH  - Free Radicals
MH  - Glutathione/metabolism
MH  - Glutathione Peroxidase/metabolism
MH  - Histocytochemistry
MH  - Lipid Peroxides/cerebrospinal fluid/*metabolism
MH  - Parietal Lobe/metabolism
MH  - Pons/metabolism
MH  - Spasm
MH  - Subarachnoid Hemorrhage/*complications/metabolism/pathology
MH  - Superoxide Dismutase/metabolism
MH  - Temporal Lobe/metabolism
MH  - Vascular Diseases/*etiology
EDAT- 1988/02/01 00:00
MHDA- 1988/02/01 00:01
CRDT- 1988/02/01 00:00
PHST- 1988/02/01 00:00 [pubmed]
PHST- 1988/02/01 00:01 [medline]
PHST- 1988/02/01 00:00 [entrez]
AID - 10.1038/jcbfm.1988.1 [doi]
PST - ppublish
SO  - J Cereb Blood Flow Metab. 1988 Feb;8(1):1-8. doi: 10.1038/jcbfm.1988.1.