PMID- 33392247
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210105
IS  - 2296-875X (Print)
IS  - 2296-875X (Electronic)
IS  - 2296-875X (Linking)
VI  - 7
DP  - 2020
TI  - Is Vestibular Meniere's Disease Associated With Endolymphatic Hydrops?
PG  - 601692
LID - 10.3389/fsurg.2020.601692 [doi]
LID - 601692
AB  - Background: Vestibular Meniere's disease (American Academy of Ophthalmology and 
      Otolaryngology, 1972) also known as possible Meniere's disease (American Academy 
      of Otolaryngology Head and Neck Surgery, 1995) or vestibular type of atypical 
      Meniere's disease (V-AMD) (Japan Society for Equilibrium Research, 2017) is 
      characterized by an episodic vertigo without hearing loss. Though named as 
      Meniere's disease (MD), this entity may not be caused solely by endolymphatic 
      hydrops (EH). Objective: To estimate the role of EH in vestibular Meniere's 
      disease in comparison with definite Meniere's disease. Methods: Thirty patients 
      with unilateral definite MD and 16 patients with vestibular Meniere's disease 
      were included. Those who met the criteria for definite or probable vestibular 
      migraine were excluded. All patients underwent vestibular assessments including 
      inner ear MRI 4 h after intravenous gadolinium injection, bithermal caloric 
      testing, directional preponderance of vestibulo-ocular reflex in rotatory chair 
      test, cervical- and ocular-vestibular evoked myogenic potential, stepping test, 
      dizziness handicap inventory (DHI), and hospital anxiety and depression scale 
      (HADS). All above tests and frequency/duration of vertigo spells were compared 
      between vestibular Meniere's disease and MD. Results: Even in unilateral MD, 
      cochlear and vestibular endolymphatic hydrops (c-, v-EH) were demonstrated not 
      only in the affected side but also in the healthy side in more than half of 
      patients. Positive rate of v-EH in vestibular Meniere's disease (68.8%) was as 
      high as that of MD (80%). In vestibular Meniere's disease, the number of 
      bilateral EH was higher in the vestibule (56.3%) than that in the cochlea 
      (25.0%). There were no differences in vestibular tests and DHI between vestibular 
      Meniere's disease and MD; however, the frequency of vertigo spells was lower in 
      vestibular Meniere's disease (p = 0.001). The total HADS score in the MD group 
      was significantly higher than that in the vestibular Meniere's disease group. 
      Conclusions: MD is a systemic disease with bilateral involvement of inner ears. 
      V-EH is a major pathophysiology of vestibular Meniere's disease, which would 
      precede c-EH in the development of vestibular Meniere's disease, a milder subtype 
      of MD. MRI is useful for differentiating MD from other vertigo attacks caused by 
      different pathologies in bringing EH into evidence.
CI  - Copyright (c) 2020 Morita, Takahashi, Ohshima, Yagi, Kitazawa, Yamagishi, Izumi and 
      Horii.
FAU - Morita, Yuka
AU  - Morita Y
AD  - Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medical 
      and Dental Sciences, Niigata University, Niigata, Japan.
FAU - Takahashi, Kuniyuki
AU  - Takahashi K
AD  - Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medical 
      and Dental Sciences, Niigata University, Niigata, Japan.
FAU - Ohshima, Shinsuke
AU  - Ohshima S
AD  - Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medical 
      and Dental Sciences, Niigata University, Niigata, Japan.
FAU - Yagi, Chihiro
AU  - Yagi C
AD  - Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medical 
      and Dental Sciences, Niigata University, Niigata, Japan.
FAU - Kitazawa, Meiko
AU  - Kitazawa M
AD  - Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medical 
      and Dental Sciences, Niigata University, Niigata, Japan.
FAU - Yamagishi, Tatsuya
AU  - Yamagishi T
AD  - Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medical 
      and Dental Sciences, Niigata University, Niigata, Japan.
FAU - Izumi, Shuji
AU  - Izumi S
AD  - Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medical 
      and Dental Sciences, Niigata University, Niigata, Japan.
FAU - Horii, Arata
AU  - Horii A
AD  - Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medical 
      and Dental Sciences, Niigata University, Niigata, Japan.
LA  - eng
PT  - Journal Article
DEP - 20201218
PL  - Switzerland
TA  - Front Surg
JT  - Frontiers in surgery
JID - 101645127
PMC - PMC7775543
OTO - NOTNLM
OT  - Meniere's disease
OT  - diagnosis
OT  - endolymphatic hydrops (EH)
OT  - episodic vertigo
OT  - magnetic resonance imaging
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/01/05 06:00
MHDA- 2021/01/05 06:01
PMCR- 2020/12/18
CRDT- 2021/01/04 05:30
PHST- 2020/09/01 00:00 [received]
PHST- 2020/11/02 00:00 [accepted]
PHST- 2021/01/04 05:30 [entrez]
PHST- 2021/01/05 06:00 [pubmed]
PHST- 2021/01/05 06:01 [medline]
PHST- 2020/12/18 00:00 [pmc-release]
AID - 10.3389/fsurg.2020.601692 [doi]
PST - epublish
SO  - Front Surg. 2020 Dec 18;7:601692. doi: 10.3389/fsurg.2020.601692. eCollection 
      2020.