PMID- 33392917
OWN - NLM
STAT- MEDLINE
DCOM- 20220401
LR  - 20220531
IS  - 1573-6830 (Electronic)
IS  - 0272-4340 (Linking)
VI  - 42
IP  - 4
DP  - 2022 May
TI  - Effects of Thrombin on the Neurovascular Unit in Cerebral Ischemia.
PG  - 973-984
LID - 10.1007/s10571-020-01019-6 [doi]
AB  - Cerebral ischemia is a cerebrovascular disease with high morbidity and mortality 
      that poses a significant burden on society and the economy. About 60% of cerebral 
      ischemia is caused by thrombus, and the formation of thrombus proceeds from 
      insoluble fibrin, following its transformation from liquid fibrinogen. In 
      thrombus-induced ischemia, increased permeability of the blood-brain barrier 
      (BBB), followed by the extravasation of blood components into the brain results 
      in an altered brain microenvironment. Changes in the brain microenvironment 
      affect brain function and the neurovascular unit (NVU), the working unit of the 
      brain. Recent studies have reported that coagulation factors interact with the 
      NVU and its components, but the specific function of this interaction is highly 
      speculative and warrants further investigations. In this article, we reviewed the 
      role of coagulation factors in cerebral ischemia and the role of coagulation 
      factors in thrombosis. Additionally, the influence of thrombin on the NVU is 
      introduced, as well as in the function of NVU, which may help to explore part of 
      brain injury mechanism during ischemia. Lastly, we propose some novel therapeutic 
      approaches on ischemic stroke by reducing the risk of coagulation.
CI  - (c) 2021. The Author(s), under exclusive licence to Springer Science+Business 
      Media, LLC part of Springer Nature.
FAU - Cao, Hui
AU  - Cao H
AUID- ORCID: 0000-0002-4561-399X
AD  - Institute of Basic Medical Sciences of Xiyuan Hospital, China Academy of Chinese 
      Medical Sciences, Beijing Key Laboratory of Pharmacology of Chinese Materia 
      Medica, Beijing, 100091, China.
FAU - Seto, Sai Wang
AU  - Seto SW
AD  - Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic 
      University, Hung Hom, Kowloon, Hong Kong SAR, PR China.
AD  - NICM Health Research Institute, Western Sydney University, Penrith, NSW, 2751, 
      Australia.
FAU - Bhuyan, Deep Jyoti
AU  - Bhuyan DJ
AD  - NICM Health Research Institute, Western Sydney University, Penrith, NSW, 2751, 
      Australia.
FAU - Chan, Hoi Huen
AU  - Chan HH
AD  - Hong Kong Community College, The Hong Kong Polytechnic University, Hung Hom, 
      Kowloon, Hong Kong.
FAU - Song, Wenting
AU  - Song W
AUID- ORCID: 0000-0001-7167-1635
AD  - Institute of Basic Medical Sciences of Xiyuan Hospital, China Academy of Chinese 
      Medical Sciences, Beijing Key Laboratory of Pharmacology of Chinese Materia 
      Medica, Beijing, 100091, China. wenting_song1@163.com.
LA  - eng
GR  - 81603617/Young Scientists Fund/
GR  - ZZ13-YQ-007/Fundamental Research Funds for Central Universities of the Central 
      South University/
PT  - Journal Article
PT  - Review
DEP - 20210103
PL  - United States
TA  - Cell Mol Neurobiol
JT  - Cellular and molecular neurobiology
JID - 8200709
RN  - EC 3.4.21.5 (Thrombin)
SB  - IM
MH  - Blood-Brain Barrier
MH  - Brain/blood supply
MH  - *Brain Ischemia
MH  - Humans
MH  - *Ischemic Stroke
MH  - Thrombin
OTO - NOTNLM
OT  - Cerebral ischemia
OT  - Coagulation
OT  - Mechanism
OT  - Neurovascular unit
OT  - Thrombin
OT  - Thrombus
EDAT- 2021/01/05 06:00
MHDA- 2022/04/02 06:00
CRDT- 2021/01/04 05:34
PHST- 2020/08/04 00:00 [received]
PHST- 2020/11/25 00:00 [accepted]
PHST- 2021/01/05 06:00 [pubmed]
PHST- 2022/04/02 06:00 [medline]
PHST- 2021/01/04 05:34 [entrez]
AID - 10.1007/s10571-020-01019-6 [pii]
AID - 10.1007/s10571-020-01019-6 [doi]
PST - ppublish
SO  - Cell Mol Neurobiol. 2022 May;42(4):973-984. doi: 10.1007/s10571-020-01019-6. Epub 
      2021 Jan 3.