PMID- 33393725
OWN - NLM
STAT- MEDLINE
DCOM- 20211221
LR  - 20240330
IS  - 2051-817X (Electronic)
IS  - 2051-817X (Linking)
VI  - 9
IP  - 1
DP  - 2021 Jan
TI  - Prior oxygenation, but not chemoreflex responsiveness, determines breath-hold 
      duration during voluntary apnea.
PG  - e14664
LID - 10.14814/phy2.14664 [doi]
LID - e14664
AB  - Central and peripheral respiratory chemoreceptors are stimulated during voluntary 
      breath holding due to chemostimuli (i.e., hypoxia and hypercapnia) accumulating 
      at the metabolic rate. We hypothesized that voluntary breath-hold duration (BHD) 
      would be (a) positively related to the initial pressure of inspired oxygen prior 
      to breath holding, and (b) negatively correlated with respiratory chemoreflex 
      responsiveness. In 16 healthy participants, voluntary breath holds were performed 
      under three conditions: hyperoxia (following five normal tidal breaths of 100% 
      O(2) ), normoxia (breathing room air), and hypoxia (following ~30-min of 
      13.5%-14% inspired O(2) ). In addition, the hypoxic ventilatory response (HVR) 
      was tested and steady-state chemoreflex drive (SS-CD) was calculated in room air 
      and during steady-state hypoxia. We found that (a) voluntary BHD was positively 
      related to initial oxygen status in a dose-dependent fashion, (b) the HVR was not 
      correlated with BHD in any oxygen condition, and (c) SS-CD magnitude was not 
      correlated with BHD in normoxia or hypoxia. Although chemoreceptors are likely 
      stimulated during breath holding, they appear to contribute less to BHD compared 
      to other factors such as volitional drive or lung volume.
CI  - (c) 2021 The Authors. Physiological Reports published by Wiley Periodicals LLC on 
      behalf of The Physiological Society and the American Physiological Society.
FAU - Bruce, Christina D
AU  - Bruce CD
AD  - Department of Biology, Faculty of Science and Technology, Mount Royal University, 
      Calgary, AB, Canada.
AD  - School of Health and Exercise Sciences, Centre for Heart, Lung and Vascular 
      Health, Faculty of Health and Social Development, University of British Columbia, 
      Kelowna, BC, Canada.
FAU - Vanden Berg, Emily R
AU  - Vanden Berg ER
AD  - Department of Biology, Faculty of Science and Technology, Mount Royal University, 
      Calgary, AB, Canada.
AD  - Department of Biology, Faculty of Science, University of Victoria, Victoria, BC, 
      Canada.
AD  - Faculty of Kinesiology, Sport, and Recreation, University of Alberta, Edmonton, 
      AB, Canada.
FAU - Pfoh, Jamie R
AU  - Pfoh JR
AD  - Department of Biology, Faculty of Science and Technology, Mount Royal University, 
      Calgary, AB, Canada.
FAU - Steinback, Craig D
AU  - Steinback CD
AD  - Faculty of Kinesiology, Sport, and Recreation, University of Alberta, Edmonton, 
      AB, Canada.
FAU - Day, Trevor A
AU  - Day TA
AUID- ORCID: 0000-0001-7102-4235
AD  - Department of Biology, Faculty of Science and Technology, Mount Royal University, 
      Calgary, AB, Canada.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Physiol Rep
JT  - Physiological reports
JID - 101607800
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Adult
MH  - Apnea/*physiopathology
MH  - Breath Holding
MH  - Chemoreceptor Cells/*metabolism
MH  - Female
MH  - Humans
MH  - Hypercapnia/*physiopathology
MH  - Hypoxia/*physiopathology
MH  - Lung/*physiology
MH  - Male
MH  - Oxygen/*physiology
MH  - Reflex/*physiology
PMC - PMC7780234
OTO - NOTNLM
OT  - breath-hold duration
OT  - hypoxic ventilatory response
OT  - oxygen
OT  - peripheral respiratory chemoreflex
OT  - respiratory chemoreceptors
OT  - steady-state chemoreflex drive
COIS- None declared.
EDAT- 2021/01/05 06:00
MHDA- 2021/12/22 06:00
PMCR- 2021/01/04
CRDT- 2021/01/04 09:23
PHST- 2020/06/06 00:00 [received]
PHST- 2020/11/05 00:00 [revised]
PHST- 2020/11/11 00:00 [accepted]
PHST- 2021/01/04 09:23 [entrez]
PHST- 2021/01/05 06:00 [pubmed]
PHST- 2021/12/22 06:00 [medline]
PHST- 2021/01/04 00:00 [pmc-release]
AID - PHY214664 [pii]
AID - 10.14814/phy2.14664 [doi]
PST - ppublish
SO  - Physiol Rep. 2021 Jan;9(1):e14664. doi: 10.14814/phy2.14664.