PMID- 33393736
OWN - NLM
STAT- MEDLINE
DCOM- 20220117
LR  - 20220117
IS  - 1755-3768 (Electronic)
IS  - 1755-375X (Print)
IS  - 1755-375X (Linking)
VI  - 99
IP  - 7
DP  - 2021 Nov
TI  - Light-induced modifications of the outer retinal hyperreflective layers on 
      spectral-domain optical coherence tomography in humans: an experimental study.
PG  - 765-772
LID - 10.1111/aos.14723 [doi]
AB  - PURPOSE: Numerous small hyperreflective dots (HRDs) can be seen within the 
      hyporeflective layer between the ellipsoid zone (EZ) and the interdigitation zone 
      (IZ) on C-scan spectral-domain optical coherence tomography (SD-OCT) with a yet 
      unknown variation under light conditions. The aim of this study was to explore 
      light-induced SD-OCT changes in these HRDs. METHODS: The study subjects were 
      randomly assigned to two groups: Group 1 experienced a dark adaptation protocol 
      followed by intense retinal photobleaching, while Group 2, serving as the control 
      group, was exposed to constant ambient light without any variation. The number of 
      HRDs was automatically counted. RESULTS: Twenty healthy volunteers were 
      prospectively included. The number of HRDs differed significantly over time 
      (p = 0.0013). They decreased in Group 1 after dark adaptation and retinal 
      photobleaching before returning to baseline levels 30 min later; conversely, they 
      remained relatively constant in Group 2 throughout the study (p < 0.001). 
      Light-skinned subjects had less HRD than dark-skinned subjects. CONCLUSION: We 
      observed light-induced modifications in the space between the EZ and the IZ. We 
      hypothesize that the HRDs visible in this zone correspond to melanosomes that are 
      mobilized during the light stimulation protocol. Larger studies are recommended 
      to further evaluate and confirm light-induced SD-OCT changes under physiological 
      and pathological conditions.
CI  - (c) 2021 The Authors. Acta Ophthalmologica published by John Wiley & Sons Ltd on 
      behalf of Acta Ophthalmologica Scandinavica Foundation.
FAU - Mathis, Thibaud
AU  - Mathis T
AUID- ORCID: 0000-0002-1418-1872
AD  - Department of Ophthalmology, Croix-Rousse University Hospital, Hospices Civils de 
      Lyon, University of Medicine Lyon 1, Lyon, France.
AD  - UMR-CNRS 5510 Mateis, Lyon 1 University, Lyon, France.
AD  - INSERM, CNRS, Institut de la Vision, Sorbonne University, Paris, France.
FAU - Vasseur, Vivien
AU  - Vasseur V
AD  - Department of Ophthalmology, Rothschild Foundation, Paris, France.
FAU - Zuber, Kevin
AU  - Zuber K
AD  - Department of Ophthalmology, Rothschild Foundation, Paris, France.
FAU - Arej, Nicolas
AU  - Arej N
AUID- ORCID: 0000-0003-0481-2228
AD  - Department of Ophthalmology, Rothschild Foundation, Paris, France.
FAU - Loria, Olivier
AU  - Loria O
AD  - Department of Ophthalmology, Croix-Rousse University Hospital, Hospices Civils de 
      Lyon, University of Medicine Lyon 1, Lyon, France.
AD  - UMR-CNRS 5510 Mateis, Lyon 1 University, Lyon, France.
FAU - Kodjikian, Laurent
AU  - Kodjikian L
AD  - Department of Ophthalmology, Croix-Rousse University Hospital, Hospices Civils de 
      Lyon, University of Medicine Lyon 1, Lyon, France.
AD  - UMR-CNRS 5510 Mateis, Lyon 1 University, Lyon, France.
FAU - Sennlaub, Florian
AU  - Sennlaub F
AD  - INSERM, CNRS, Institut de la Vision, Sorbonne University, Paris, France.
FAU - Mauget-Faysse, Martine
AU  - Mauget-Faysse M
AD  - Department of Ophthalmology, Rothschild Foundation, Paris, France.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20210104
PL  - England
TA  - Acta Ophthalmol
JT  - Acta ophthalmologica
JID - 101468102
SB  - IM
MH  - Adult
MH  - Dark Adaptation/*physiology
MH  - Female
MH  - Follow-Up Studies
MH  - Healthy Volunteers
MH  - Humans
MH  - *Light
MH  - Male
MH  - Prospective Studies
MH  - Retinal Photoreceptor Cell Outer Segment/physiology/*radiation effects
MH  - Retinal Pigment Epithelium/*diagnostic imaging/physiology
MH  - Tomography, Optical Coherence/*methods
MH  - Visual Acuity
PMC - PMC8596705
OTO - NOTNLM
OT  - melanosome
OT  - optical coherence tomography
OT  - outer retinal layers
OT  - phagosome
OT  - retinal pigment epithelium
EDAT- 2021/01/05 06:00
MHDA- 2022/01/18 06:00
PMCR- 2021/11/17
CRDT- 2021/01/04 09:23
PHST- 2020/11/14 00:00 [revised]
PHST- 2019/11/24 00:00 [received]
PHST- 2020/11/23 00:00 [accepted]
PHST- 2021/01/05 06:00 [pubmed]
PHST- 2022/01/18 06:00 [medline]
PHST- 2021/01/04 09:23 [entrez]
PHST- 2021/11/17 00:00 [pmc-release]
AID - AOS14723 [pii]
AID - 10.1111/aos.14723 [doi]
PST - ppublish
SO  - Acta Ophthalmol. 2021 Nov;99(7):765-772. doi: 10.1111/aos.14723. Epub 2021 Jan 4.