PMID- 3339427
OWN - NLM
STAT- MEDLINE
DCOM- 19880322
LR  - 20191101
IS  - 0270-6474 (Print)
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Linking)
VI  - 8
IP  - 2
DP  - 1988 Feb
TI  - Evidence that the neural pathways involved in backward conditioning are different 
      from those involved in forward conditioning.
PG  - 502-7
AB  - Effects of forward and backward conditioned-unconditioned stimulus (CS-US) 
      intervals on classical conditioning of the flexion reflex were examined in a 
      spinal cat preparation. A less intense conditioned stimulus (CS) was employed 
      (activation of A-alpha cutaneous fibers) compared to that of a previous study 
      (activation of both A-alpha and A-delta cutaneous fibers). Interstimulus 
      intervals (ISIs) ranging from +3.0 to -3.0 sec were examined in 9 experimental 
      groups, and results contrasted to those of an explicitly unpaired control group. 
      The ISI of -0.25 sec produced optimal backward excitatory conditioning, 
      paralleling the previous results. However, in contrast to the previous study, no 
      conditioning was observed in any of the forward ISI groups. These observations 
      support the hypothesis that backward and forward conditioning may be 
      fundamentally different phenomena, induced by CS activation of different spinal 
      reflex pathways: backward conditioning involves spinal reflex pathways activated 
      by A-alpha cutaneous fibers of the CS, while forward conditioning involves spinal 
      reflex pathways activated by A-delta cutaneous fibers of the CS.
FAU - Onifer, S M
AU  - Onifer SM
AD  - Department of Physiology, SUNY Health Science Center, Syracuse 13210.
FAU - Durkovic, R G
AU  - Durkovic RG
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
SB  - IM
MH  - Animals
MH  - Cats
MH  - Conditioning, Classical/*physiology
MH  - Female
MH  - Male
MH  - Neural Pathways/*physiology
MH  - Reflex/*physiology
MH  - Spinal Cord/physiology
PMC - PMC6569305
EDAT- 1988/02/01 00:00
MHDA- 1988/02/01 00:01
PMCR- 1988/08/01
CRDT- 1988/02/01 00:00
PHST- 1988/02/01 00:00 [pubmed]
PHST- 1988/02/01 00:01 [medline]
PHST- 1988/02/01 00:00 [entrez]
PHST- 1988/08/01 00:00 [pmc-release]
AID - 10.1523/JNEUROSCI.08-02-00502.1988 [doi]
PST - ppublish
SO  - J Neurosci. 1988 Feb;8(2):502-7. doi: 10.1523/JNEUROSCI.08-02-00502.1988.