PMID- 33394485
OWN - NLM
STAT- MEDLINE
DCOM- 20210430
LR  - 20210430
IS  - 1307-7945 (Electronic)
IS  - 1306-696X (Linking)
VI  - 27
IP  - 1
DP  - 2021 Jan
TI  - Impaction of the polylactic membrane or hydrofiber with silver dressings on the 
      interleukin-6, tumor necrosis factor-alpha, transforming growth factor-b3 levels in 
      the blood and tissues of pediatric patients with burns.
PG  - 122-131
LID - 10.14744/tjtes.2020.30483 [doi]
AB  - BACKGROUND: We aimed to evaluate the effects of two different burn dressings, 
      hydrofiber with a silver (HFAg) and polylactic membrane (PLM), on altering the 
      levels of important biomarkers Interleukin-6 (IL-6), Tumor necrosis factor-alpha 
      (TNF-alpha), Transforming growth factor-beta3 (TGF-beta3) in blood and burnt tissue in 
      children with second-degree burns. METHODS: Children between the ages of one to 
      16 years, with 25-50% second-degree partial-thickness burns of the total body 
      surface area were included in this study. Patients in the PLM group were dressed 
      with PLM in a typical way according to the manual. The HFAg group was dressed 
      with HFAg and a sterile cover. During and at the end of the 21-day treatment, 
      blood and skin tissue samples were taken from the two burn and control groups. 
      IL-6, TNF-alpha, and TGF-beta beta3 levels were evaluated in blood and tissue samples from 
      all groups, and the results were analyzed statistically. RESULTS: In the PLM 
      group, IL-6 and TNF-alpha levels decreased early days in both serum and tissue 
      samples to reach normal ranges compared with the HFAg group. In the PLM group, 
      TGF-beta3 levels were elevated than in other groups for two weeks. CONCLUSION: In 
      this study, we found that PLM controls inflammation earlier in both systemic and 
      burn tissue. We also found that PLM increased the level of TGF-beta3, which may be 
      associated with the prevention of the development of hypertrophic scar in the 
      burn wound, in the blood and burn tissue during this study.
FAU - Demircan, Mehmet
AU  - Demircan M
AD  - Department of Pediatric Surgery and Pediatric Intensive Burn Care Unit, Inonu 
      University Faculty of Medicine, Malatya-Turkey.
FAU - Gurunluoglu, Kubilay
AU  - Gurunluoglu K
AD  - Department of Pediatric Surgery and Pediatric Intensive Burn Care Unit, Inonu 
      University Faculty of Medicine, Malatya-Turkey.
FAU - Gozukara Bag, Harika Gozde
AU  - Gozukara Bag HG
AD  - Department of Biostatistics and Medical Informatics, Inonu University Faculty of 
      Medicine, Malatya-Turkey.
FAU - Kocbiyik, Alper
AU  - Kocbiyik A
AD  - Department of Pathology Laboratory, Istanbul Bakirkoy Dr. Sadi Konuk Training and 
      Research Hospital, Istanbul-Turkey.
FAU - Gul, Mehmet
AU  - Gul M
AD  - Department of Histology and Embryology, Inonu University Faculty of Medicine, 
      Malatya-Turkey.
FAU - Uremis, Nuray
AU  - Uremis N
AD  - Department of Medical Biochemistry, Inonu University Faculty of Medicine, 
      Malatya-Turkey.
FAU - Gul, Semir
AU  - Gul S
AD  - Department of Histology and Embryology, Inonu University Faculty of Medicine, 
      Malatya-Turkey.
FAU - Gurunluoglu, Semra
AU  - Gurunluoglu S
AD  - Department of Pathology Laboratory, Turgut Ozal University Faculty of Medicine, 
      Training and Research Hospital, Malatya-Turkey.
FAU - Turkoz, Yusuf
AU  - Turkoz Y
AD  - Department of Medical Biochemistry, Inonu University Faculty of Medicine, 
      Malatya-Turkey.
FAU - Tasci, Aytac
AU  - Tasci A
AD  - Department of Pediatric Surgery and Pediatric Intensive Burn Care Unit, Inonu 
      University Faculty of Medicine, Malatya-Turkey.
LA  - eng
PT  - Clinical Study
PT  - Journal Article
TT  - Pediyatrik yanik hastalarinda polilaktik membran veya gumuslu hidrofiber 
      pansumanlarin kan ve dokuda interlokin-6, tumor nekrozis faktor-alpha, transforming 
      buyume faktoru-b3 duzeylerine etkisi.
PL  - Turkey
TA  - Ulus Travma Acil Cerrahi Derg
JT  - Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency 
      surgery : TJTES
JID - 101274231
RN  - 0 (Cytokines)
RN  - 0 (Polyesters)
RN  - 3M4G523W1G (Silver)
RN  - 459TN2L5F5 (poly(lactide))
SB  - IM
MH  - Adolescent
MH  - *Bandages
MH  - *Burns/metabolism/therapy
MH  - Child
MH  - Child, Preschool
MH  - Cytokines/*analysis
MH  - Humans
MH  - Infant
MH  - Polyesters/*therapeutic use
MH  - Prospective Studies
MH  - Silver/*therapeutic use
MH  - Skin/chemistry/metabolism
EDAT- 2021/01/05 06:00
MHDA- 2021/05/01 06:00
CRDT- 2021/01/04 12:19
PHST- 2021/01/04 12:19 [entrez]
PHST- 2021/01/05 06:00 [pubmed]
PHST- 2021/05/01 06:00 [medline]
AID - 10.14744/tjtes.2020.30483 [doi]
PST - ppublish
SO  - Ulus Travma Acil Cerrahi Derg. 2021 Jan;27(1):122-131. doi: 
      10.14744/tjtes.2020.30483.