PMID- 33394507
OWN - NLM
STAT- MEDLINE
DCOM- 20220308
LR  - 20220308
IS  - 1601-0825 (Electronic)
IS  - 1354-523X (Linking)
VI  - 28
IP  - 3
DP  - 2022 Apr
TI  - Oral pigmented lesions in syndromic individuals: A systematic review.
PG  - 531-540
LID - 10.1111/odi.13769 [doi]
AB  - OBJECTIVE: To systematically integrate the available data published in the 
      literature on oral pigmented lesions (OPL) associated with syndromes, summarizing 
      the clinical and demographic features of the individuals. MATERIALS AND METHODS: 
      An electronic search was undertaken in six databases. Eligibility criteria were 
      articles in English, Spanish, and Portuguese describing case reports or case 
      series of OPL associated with syndromes. Data were aggregated and statistically 
      evaluated. RESULTS: About 108 articles reporting 149 cases of individuals with 
      syndromes were identified. Among the affected individuals, nine syndromes were 
      reported. The mean age at diagnosis was 35.93 years (0.41 to 83 years), with a 
      predilection for white (n = 85/85.86%) female (n = 102/68.46%) individuals. As 
      regards the number of lesions, 109 (73.15%) were multiple and 40 (26.85%) were 
      single. Lip represented the anatomical location more affected (122 cases/38.01%), 
      followed by the buccal mucosa (100 cases/31.15%). Brownish lesions accounted for 
      82 (69.49%) cases. The mean time of evolution was 10.52 years (0.16 to 56 years). 
      OPL preceding diagnosis of the syndrome was observed in 111 (74.50%) cases. 
      CONCLUSIONS: Although these syndromes are uncommon, dentists should be able to 
      recognize their manifestations, since oral manifestations can represent an 
      important aspect in early diagnosis.
CI  - (c) 2021 Wiley Periodicals LLC.
FAU - Ferreira, Luise Dos Santos
AU  - Ferreira LDS
AD  - Diagnostic Center for Oral Diseases, School of Dentistry, Universidade Federal de 
      Pelotas, Pelotas, Brazil.
FAU - Calderipe, Camila Barcellos
AU  - Calderipe CB
AD  - Diagnostic Center for Oral Diseases, School of Dentistry, Universidade Federal de 
      Pelotas, Pelotas, Brazil.
FAU - Maass, Julianne Bartz
AU  - Maass JB
AD  - Diagnostic Center for Oral Diseases, School of Dentistry, Universidade Federal de 
      Pelotas, Pelotas, Brazil.
FAU - Carrard, Vinicius Coelho
AU  - Carrard VC
AUID- ORCID: 0000-0002-1624-0178
AD  - Department of Oral Pathology, School of Dentistry, Universidade Federal do Rio 
      Grande do Sul, Porto Alegre, Brazil.
FAU - Martins, Manoela Domingues
AU  - Martins MD
AUID- ORCID: 0000-0001-8662-5965
AD  - Department of Oral Pathology, School of Dentistry, Universidade Federal do Rio 
      Grande do Sul, Porto Alegre, Brazil.
AD  - Department of Oral Diagnosis, Piracicaba Dental School, Universidade de Campinas, 
      Piracicaba, Brazil.
FAU - Abreu, Lucas Guimaraes
AU  - Abreu LG
AUID- ORCID: 0000-0003-2258-8071
AD  - Department of Child's and Adolescent's Oral Health, School of Dentistry, 
      Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
FAU - Schuch, Lauren Frenzel
AU  - Schuch LF
AUID- ORCID: 0000-0002-0993-936X
AD  - Department of Oral Diagnosis, Piracicaba Dental School, Universidade de Campinas, 
      Piracicaba, Brazil.
FAU - Uchoa Vasconcelos, Ana Carolina
AU  - Uchoa Vasconcelos AC
AUID- ORCID: 0000-0001-6560-9536
AD  - Diagnostic Center for Oral Diseases, School of Dentistry, Universidade Federal de 
      Pelotas, Pelotas, Brazil.
LA  - eng
GR  - 001/Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior/
GR  - 310797/2019-5/Conselho Nacional de Desenvolvimento Cientifico e Tecnologico/
PT  - Journal Article
PT  - Review
PT  - Systematic Review
DEP - 20210116
PL  - Denmark
TA  - Oral Dis
JT  - Oral diseases
JID - 9508565
MH  - Female
MH  - Humans
MH  - *Hyperpigmentation/diagnosis
MH  - Mouth Mucosa/pathology
MH  - Syndrome
OTO - NOTNLM
OT  - Laugier-Hunziker syndrome
OT  - Peutz-Jeghers syndrome
OT  - hyperpigmentation
OT  - oral cavity
OT  - pigmentation
EDAT- 2021/01/05 06:00
MHDA- 2022/03/09 06:00
CRDT- 2021/01/04 12:19
PHST- 2020/12/07 00:00 [revised]
PHST- 2020/11/05 00:00 [received]
PHST- 2020/12/29 00:00 [accepted]
PHST- 2021/01/05 06:00 [pubmed]
PHST- 2022/03/09 06:00 [medline]
PHST- 2021/01/04 12:19 [entrez]
AID - 10.1111/odi.13769 [doi]
PST - ppublish
SO  - Oral Dis. 2022 Apr;28(3):531-540. doi: 10.1111/odi.13769. Epub 2021 Jan 16.