PMID- 33395612
OWN - NLM
STAT- MEDLINE
DCOM- 20211013
LR  - 20230126
IS  - 1878-9307 (Electronic)
IS  - 1878-9293 (Print)
IS  - 1878-9293 (Linking)
VI  - 47
DP  - 2021 Feb
TI  - Early childhood stress is associated with blunted development of ventral 
      tegmental area functional connectivity.
PG  - 100909
LID - S1878-9293(20)30158-4 [pii]
LID - 10.1016/j.dcn.2020.100909 [doi]
LID - 100909
AB  - Early life stress increases risk for later psychopathology, due in part to 
      changes in dopaminergic brain systems that support reward processing and 
      motivation. Work in animals has shown that early life stress has a profound 
      impact on the ventral tegmental area (VTA), which provides dopamine to regions 
      including nucleus accumbens (NAcc), anterior hippocampus, and medial prefrontal 
      cortex (mPFC), with cascading effects over the course of development. However, 
      little is known about how early stress exposure shifts the developmental 
      trajectory of mesocorticolimbic circuitry in humans. In the current study, 88 
      four- to nine-year-old children participated in resting-state fMRI. Parents 
      completed questionnaires on their children's chronic stress exposure, including 
      socioeconomic status (SES) and adverse childhood experiences (ACEs). We found an 
      age x SES interaction on VTA connectivity, such that children from higher SES 
      backgrounds showed a positive relationship between age and VTA-mPFC connectivity. 
      Similarly, we found an age x ACEs exposure interaction on VTA connectivity, such 
      that children with no ACEs exposure showed a positive relationship between age 
      and VTA-mPFC connectivity. Our findings suggest that early stress exposure 
      relates to the blunted maturation of VTA connectivity in young children, which 
      may lead to disrupted reward processing later in childhood and beyond.
CI  - Copyright (c) 2021 The Authors. Published by Elsevier Ltd.. All rights reserved.
FAU - Park, Anne T
AU  - Park AT
AD  - Department of Psychology, School of Arts and Sciences, University of 
      Pennsylvania, United States.
FAU - Tooley, Ursula A
AU  - Tooley UA
AD  - Department of Psychology, School of Arts and Sciences, University of 
      Pennsylvania, United States; Neuroscience Graduate Group, Perelman School of 
      Medicine, University of Pennsylvania, United States.
FAU - Leonard, Julia A
AU  - Leonard JA
AD  - Department of Psychology, School of Arts and Sciences, University of 
      Pennsylvania, United States.
FAU - Boroshok, Austin L
AU  - Boroshok AL
AD  - Department of Psychology, School of Arts and Sciences, University of 
      Pennsylvania, United States.
FAU - McDermott, Cassidy L
AU  - McDermott CL
AD  - Department of Psychology, School of Arts and Sciences, University of 
      Pennsylvania, United States.
FAU - Tisdall, M Dylan
AU  - Tisdall MD
AD  - Department of Radiology, Perelman School of Medicine, University of Pennsylvania, 
      United States.
FAU - Mackey, Allyson P
AU  - Mackey AP
AD  - Department of Psychology, School of Arts and Sciences, University of 
      Pennsylvania, United States. Electronic address: mackeya@upenn.edu.
LA  - eng
GR  - R34 DA050297/DA/NIDA NIH HHS/United States
GR  - S10 OD023495/OD/NIH HHS/United States
GR  - T32 MH017168/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20201225
PL  - Netherlands
TA  - Dev Cogn Neurosci
JT  - Developmental cognitive neuroscience
JID - 101541838
SB  - IM
MH  - Child
MH  - Child, Preschool
MH  - Hippocampus
MH  - Humans
MH  - Nucleus Accumbens/diagnostic imaging
MH  - Prefrontal Cortex
MH  - Reward
MH  - *Ventral Tegmental Area
PMC - PMC7785957
OTO - NOTNLM
OT  - Adversity
OT  - Childhood
OT  - Resting-state fMRI
OT  - Reward
OT  - Socioeconomic status
COIS- The authors report no declarations of interest.
EDAT- 2021/01/05 06:00
MHDA- 2021/10/14 06:00
PMCR- 2020/12/25
CRDT- 2021/01/04 20:06
PHST- 2020/05/29 00:00 [received]
PHST- 2020/10/10 00:00 [revised]
PHST- 2020/12/22 00:00 [accepted]
PHST- 2021/01/05 06:00 [pubmed]
PHST- 2021/10/14 06:00 [medline]
PHST- 2021/01/04 20:06 [entrez]
PHST- 2020/12/25 00:00 [pmc-release]
AID - S1878-9293(20)30158-4 [pii]
AID - 100909 [pii]
AID - 10.1016/j.dcn.2020.100909 [doi]
PST - ppublish
SO  - Dev Cogn Neurosci. 2021 Feb;47:100909. doi: 10.1016/j.dcn.2020.100909. Epub 2020 
      Dec 25.