PMID- 33395907
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210111
IS  - 2210-2612 (Print)
IS  - 2210-2612 (Electronic)
IS  - 2210-2612 (Linking)
VI  - 77
DP  - 2020
TI  - Axillary Hibernoma in woman with Lobular breast cancer and MEN1 syndrome: A case 
      report.
PG  - 834-838
LID - S2210-2612(20)31096-8 [pii]
LID - 10.1016/j.ijscr.2020.11.073 [doi]
AB  - INTRODUCTION: The present study reports the case of an axillary hibernoma in a 
      patient with lobular homolateral breast cancer and multiple endocrine neoplasia 
      type1 (MEN-1). Hibernoma is a rare benign adipose tissue tumor, and usually 
      manifests as a slowly growing and painless rubbery mass. These tumors can arise 
      in various sites, but mammary hibernomas remain extraordinarily uncommon. 
      Although hibernomas are metabolically active and therefore "glucose-avid" on 
      fluorodeoxyglucose CT-positron emission tomography (FDG CT-PET), imaging alone is 
      inadequate in providing a reliable diagnosis and definitive differential 
      diagnosis from other malignancy. Only complete surgical excision is diagnostic 
      and, in most cases, curative. PRESENTATION OF CASE: A 42-years-old woman was 
      followed for MEN-1 syndrome associating with hyperparathyroidism, insulinoma, 
      non-secretory adrenal adenoma and thyroid lump. A FDG CT-PET found high glucid 
      hypermetabolism in thickened elongated area on the front axillary line. Hibernoma 
      was diagnosed after realization of prophylactic left mastectomy, homolateral 
      sentinel lymph node biopsy and exeresis of the known axillary lesion. DISCUSSION: 
      Clinical importance lies in distinguishing hibernoma from other benign and 
      malignant breast neoplasms, as well as inflammatory conditions that come into the 
      histologic or radiologic differential. Hibernoma is not currently classi fi ed as a 
      non-endocrine tumor related to MEN1, but this association could be not fortuitous 
      for the linkage between modification of Menin protein function and pathogenesis 
      of hibernomas. CONCLUSION: Our case deserves extraordinary attention because, not 
      only it's a case of MEN1 syndrome associated with hibernoma, but in the context 
      of this lesion there are multiple micro-foci of infiltrating lobular carcinoma.
CI  - Copyright (c) 2020. Published by Elsevier Ltd.
FAU - Deguidi, Giulia
AU  - Deguidi G
AD  - Complex Operative Unit of Breast Surgery - Breast Unit AOUI, Verona, Italy.
FAU - Mirandola, Sara
AU  - Mirandola S
AD  - Complex Operative Unit of Breast Surgery - Breast Unit AOUI, Verona, Italy.
FAU - Nottegar, Alessia
AU  - Nottegar A
AD  - Department of Pathology and Diagnostics- Breast Unit AOUI, Verona, Italy.
FAU - Tsvetkova, Vassilena
AU  - Tsvetkova V
AD  - Department of Pathology and Diagnostics- Breast Unit AOUI, Verona, Italy.
FAU - Bianchi, Beatrice
AU  - Bianchi B
AD  - Complex Operative Unit of Breast Surgery - Breast Unit AOUI, Verona, Italy.
FAU - Pellini, Francesca
AU  - Pellini F
AD  - Complex Operative Unit of Breast Surgery - Breast Unit AOUI, Verona, Italy. 
      Electronic address: francesca.pellini@aovr.veneto.it.
LA  - eng
PT  - Case Reports
DEP - 20201127
PL  - Netherlands
TA  - Int J Surg Case Rep
JT  - International journal of surgery case reports
JID - 101529872
PMC - PMC7721659
OTO - NOTNLM
OT  - Breast cancer
OT  - Brown fat tumor
OT  - Case report
OT  - FDG CT-PET
OT  - Hibernoma
OT  - MEN-1 syndrome
EDAT- 2021/01/06 06:00
MHDA- 2021/01/06 06:01
PMCR- 2020/11/27
CRDT- 2021/01/05 01:06
PHST- 2020/08/12 00:00 [received]
PHST- 2020/11/11 00:00 [revised]
PHST- 2020/11/11 00:00 [accepted]
PHST- 2021/01/05 01:06 [entrez]
PHST- 2021/01/06 06:00 [pubmed]
PHST- 2021/01/06 06:01 [medline]
PHST- 2020/11/27 00:00 [pmc-release]
AID - S2210-2612(20)31096-8 [pii]
AID - 10.1016/j.ijscr.2020.11.073 [doi]
PST - ppublish
SO  - Int J Surg Case Rep. 2020;77:834-838. doi: 10.1016/j.ijscr.2020.11.073. Epub 2020 
      Nov 27.