PMID- 33396395
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210218
IS  - 2227-9059 (Print)
IS  - 2227-9059 (Electronic)
IS  - 2227-9059 (Linking)
VI  - 9
IP  - 1
DP  - 2020 Dec 31
TI  - Elements of Immunoglobulin E Network Associate with Aortic valve Area in Patients 
      with Acquired Aortic Stenosis.
LID - 10.3390/biomedicines9010023 [doi]
LID - 23
AB  - Allergic mechanisms are likely involved in atherosclerosis and its clinical 
      presentations, such as coronary artery disease (CAD). It has been previously 
      reported that CAD severity associates with serum levels of immunoglobulin E 
      (IgE), the molecule that, along with its high-affinity receptor (FcԑRI), plays a 
      central role in allergic reactions. Considering multiple pathophysiological 
      similarities between atherosclerosis and acquired aortic (valve) stenosis (AS), 
      we speculated that allergic pathways could also contribute to the AS mechanisms 
      and grading. To validate this hypothesis, we first checked whether total serum 
      IgE levels associate with echocardiographic markers of AS severity. Having found 
      a positive correlation between serum IgE and aortic valve area (AVA), we further 
      speculated that also total IgE-determining genetic polymorphisms in FCER1A, a 
      locus encoding an allergen-biding FcԑRI subunit, are related to acquired AS 
      severity. Indeed, the major allele of rs2251746 polymorphism, known to associate 
      with higher IgE levels, turned out to correlate with larger AVA, a marker of less 
      severe AS. Our findings surprisingly suggest a protective role of IgE pathways 
      against AS progression. IgE-mediated protective mechanisms in AS require further 
      investigations.
FAU - Potaczek, Daniel P
AU  - Potaczek DP
AUID- ORCID: 0000-0003-0324-8506
AD  - Translational Inflammation Research Division & Core Facility for Single Cell 
      Multiomics, Medical Faculty, Philipps University Marburg, Member of the German 
      Center for Lung Research (DZL) and the Universities of Giessen and Marburg Lung 
      Center, 35043 Marburg, Germany.
AD  - Krakow Center for Medical Research and Technology, John Paul II Hospital, 31-202 
      Krakow, Poland.
FAU - Przytulska-Szczerbik, Aleksandra
AU  - Przytulska-Szczerbik A
AD  - Krakow Center for Medical Research and Technology, John Paul II Hospital, 31-202 
      Krakow, Poland.
FAU - Bazan-Socha, Stanislawa
AU  - Bazan-Socha S
AUID- ORCID: 0000-0001-9634-0963
AD  - Department of Internal Medicine, Jagiellonian University Medical College, 31-066 
      Krakow, Poland.
FAU - Jurczyszyn, Artur
AU  - Jurczyszyn A
AD  - Department of Hematology, Jagiellonian University Medical College, 31-501 Krakow, 
      Poland.
FAU - Okumura, Ko
AU  - Okumura K
AD  - Atopy Research Center, Juntendo University School of Medicine, Tokyo 113-8421, 
      Japan.
FAU - Nishiyama, Chiharu
AU  - Nishiyama C
AD  - Laboratory of Molecular Biology and Immunology, Department of Biological Science 
      and Technology, Tokyo University of Science, Tokyo 125-8585, Japan.
FAU - Undas, Anetta
AU  - Undas A
AD  - Krakow Center for Medical Research and Technology, John Paul II Hospital, 31-202 
      Krakow, Poland.
AD  - Institute of Cardiology, Jagiellonian University Medical College, 31-202 Krakow, 
      Poland.
FAU - Wypasek, Ewa
AU  - Wypasek E
AD  - Krakow Center for Medical Research and Technology, John Paul II Hospital, 31-202 
      Krakow, Poland.
AD  - Faculty of Medicine and Health Sciences, Andrzej Frycz Modrzewski Krakow 
      University, 30-705 Krakow, Poland.
LA  - eng
GR  - UMO-2013/11/B/NZ5/00157/Narodowym Centrum Nauki/
GR  - JSPS/Japan Society for the Promotion of Science/
GR  - -/Myeloma Treatment Foundation Centre/
GR  - -/Ministry of Education, Culture, Sports, Science and Technology of Japan/
PT  - Journal Article
DEP - 20201231
PL  - Switzerland
TA  - Biomedicines
JT  - Biomedicines
JID - 101691304
PMC - PMC7824289
OTO - NOTNLM
OT  - (genetic) polymorphism
OT  - AVS)
OT  - FcԑRI alpha-subunit (FcԑRIalpha) gene (FCER1A)
OT  - aortic (valve) stenosis (AS
OT  - aortic valve area (AVA)
OT  - high-affinity IgE receptor (FcԑRI)
OT  - immunoglobulin E (IgE)
COIS- The authors declare that they have no known competing financial interests.
EDAT- 2021/01/06 06:00
MHDA- 2021/01/06 06:01
PMCR- 2020/12/31
CRDT- 2021/01/05 01:12
PHST- 2020/11/29 00:00 [received]
PHST- 2020/12/23 00:00 [revised]
PHST- 2020/12/26 00:00 [accepted]
PHST- 2021/01/05 01:12 [entrez]
PHST- 2021/01/06 06:00 [pubmed]
PHST- 2021/01/06 06:01 [medline]
PHST- 2020/12/31 00:00 [pmc-release]
AID - biomedicines9010023 [pii]
AID - biomedicines-09-00023 [pii]
AID - 10.3390/biomedicines9010023 [doi]
PST - epublish
SO  - Biomedicines. 2020 Dec 31;9(1):23. doi: 10.3390/biomedicines9010023.