PMID- 33397238
OWN - NLM
STAT- MEDLINE
DCOM- 20220228
LR  - 20220228
IS  - 1875-5666 (Electronic)
IS  - 1566-5240 (Linking)
VI  - 21
IP  - 8
DP  - 2021
TI  - The Role of Retinoblastoma Protein in Cell Cycle Regulation: An Updated Review.
PG  - 620-629
LID - 10.2174/1566524020666210104113003 [doi]
AB  - Selected transcription factors have critical roles to play in organism survival 
      by regulating the expression of genes that control the adaptations needed to 
      handle stress conditions. The retinoblastoma (Rb) protein coupled with the E2F 
      transcription factor family was demonstrated to have roles in controlling the 
      cell cycle during freezing and associated environmental stresses (anoxia, 
      dehydration). Rb phosphorylation or acetylation at different sites provides a 
      mechanism for repressing cell proliferation that is under the control of E2F 
      transcription factors in animals facing stresses that disrupt cellular energetics 
      or cell volume controls. Other central regulators of the cell cycle including 
      Cyclins, Cyclin-dependent kinases (Cdks), and checkpoint proteins detect DNA 
      damage or any improper replication, blocking further progression of cell cycle 
      and interrupting cell proliferation. This review provides an insight into the 
      molecular regulatory mechanisms of cell cycle control, focusing on Rb-E2F along 
      with Cyclin-Cdk complexes typically involved in development and differentiation 
      that need to be regulated in order to survive extreme cellular stress.
CI  - Copyright(c) Bentham Science Publishers; For any queries, please email at 
      epub@benthamscience.net.
FAU - Roufayel, Rabih
AU  - Roufayel R
AD  - College of Engineering and Technology, American University of the Middle East, 
      Kuwait.
FAU - Mezher, Rabih
AU  - Mezher R
AD  - College of Engineering and Technology, American University of the Middle East, 
      Kuwait.
FAU - Storey, Kenneth B
AU  - Storey KB
AD  - Department of Biology, Carleton University, 1125 Colonel By Drive, Ottawa, ON, 
      K1S 5B6, Canada.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Netherlands
TA  - Curr Mol Med
JT  - Current molecular medicine
JID - 101093076
RN  - 0 (Cyclins)
RN  - 0 (E2F Transcription Factors)
RN  - 0 (Retinoblastoma Protein)
RN  - EC 2.7.11.22 (Cyclin-Dependent Kinases)
SB  - IM
MH  - Animals
MH  - *Cell Cycle Checkpoints
MH  - Cyclin-Dependent Kinases/genetics/metabolism
MH  - Cyclins/genetics/metabolism
MH  - E2F Transcription Factors/genetics/metabolism
MH  - Humans
MH  - Phosphorylation
MH  - Retinoblastoma Protein/genetics/*metabolism
OTO - NOTNLM
OT  - Cell cycle
OT  - Cyclin-Cdk
OT  - E2F transcription factor
OT  - chromatin remodeling
OT  - retinoblastoma
OT  - stress.
EDAT- 2021/01/06 06:00
MHDA- 2022/03/01 06:00
CRDT- 2021/01/05 05:38
PHST- 2020/09/02 00:00 [received]
PHST- 2020/11/19 00:00 [revised]
PHST- 2020/11/23 00:00 [accepted]
PHST- 2021/01/06 06:00 [pubmed]
PHST- 2022/03/01 06:00 [medline]
PHST- 2021/01/05 05:38 [entrez]
AID - CMM-EPUB-112997 [pii]
AID - 10.2174/1566524020666210104113003 [doi]
PST - ppublish
SO  - Curr Mol Med. 2021;21(8):620-629. doi: 10.2174/1566524020666210104113003.