PMID- 33397418
OWN - NLM
STAT- MEDLINE
DCOM- 20211014
LR  - 20240330
IS  - 1477-7827 (Electronic)
IS  - 1477-7827 (Linking)
VI  - 19
IP  - 1
DP  - 2021 Jan 4
TI  - Caloric restriction in female reproduction: is it beneficial or detrimental?
PG  - 1
LID - 10.1186/s12958-020-00681-1 [doi]
LID - 1
AB  - Caloric restriction (CR), an energy-restricted intervention with undernutrition 
      instead of malnutrition, is widely known to prolong lifespan and protect against 
      the age-related deteriorations. Recently it is found that CR significantly 
      affects female reproduction via hypothalamic (corticotropin releasing hormone, 
      neuropeptide Y, agouti-related peptide) and peripheral (leptin, ghrelin, insulin, 
      insulin-like growth factor) mediators, which can regulate the energy homeostasis. 
      Although CR reduces the fertility in female mammals, it exerts positive effects 
      like preserving reproductive capacity. In this review, we aim to discuss the 
      comprehensive effects of CR on the central hypothalamus-pituitary-gonad axis and 
      peripheral ovary and uterus. In addition, we emphasize the influence of CR during 
      pregnancy and highlight the relationship between CR and reproductive-associated 
      diseases. Fully understanding and analyzing the effects of CR on the female 
      reproduction could provide better strategies for the management and prevention of 
      female reproductive dysfunctions.
FAU - Sun, Jiayi
AU  - Sun J
AD  - Department of Physiology, Basic Medical College, Nanchang University, Nanchang, 
      Jiangxi, 330006, People's Republic of China.
AD  - Department of Clinical medicine, School of Queen Mary, Nanchang University, 
      Nanchang, China.
FAU - Shen, Xin
AU  - Shen X
AD  - Department of Physiology, Basic Medical College, Nanchang University, Nanchang, 
      Jiangxi, 330006, People's Republic of China.
FAU - Liu, Hui
AU  - Liu H
AD  - Department of Physiology, Basic Medical College, Nanchang University, Nanchang, 
      Jiangxi, 330006, People's Republic of China.
FAU - Lu, Siying
AU  - Lu S
AD  - Department of Physiology, Basic Medical College, Nanchang University, Nanchang, 
      Jiangxi, 330006, People's Republic of China.
FAU - Peng, Jing
AU  - Peng J
AD  - Department of Gynecology, Nanchang HongDu Hospital of Traditional Chinese 
      Medicine, 264 MinDe Road, Nanchang, Jiangxi, 330006, People's Republic of China. 
      879332555@qq.com.
FAU - Kuang, Haibin
AU  - Kuang H
AUID- ORCID: 0000-0003-4711-5449
AD  - Department of Physiology, Basic Medical College, Nanchang University, Nanchang, 
      Jiangxi, 330006, People's Republic of China. kuanghaibin@ncu.edu.cn.
AD  - Jiangxi Provincial Key Laboratory of Reproductive Physiology and Pathology, 
      Medical Experimental Teaching Center of Nanchang University, Nanchang, China. 
      kuanghaibin@ncu.edu.cn.
LA  - eng
GR  - 32060203, 81860283/National Natural Science Foundation of China/
PT  - Journal Article
PT  - Review
DEP - 20210104
PL  - England
TA  - Reprod Biol Endocrinol
JT  - Reproductive biology and endocrinology : RB&E
JID - 101153627
RN  - 0 (Ghrelin)
RN  - 0 (Insulin)
RN  - 0 (Leptin)
SB  - IM
MH  - Animals
MH  - *Caloric Restriction
MH  - Female
MH  - Ghrelin/metabolism
MH  - Humans
MH  - Hypothalamus/*physiology
MH  - Insulin/metabolism
MH  - Leptin/metabolism
MH  - Ovary/*physiology
MH  - Pituitary Gland/*physiology
MH  - Reproduction/*physiology
MH  - Uterus/*physiology
PMC - PMC7780671
OTO - NOTNLM
OT  - Caloric restriction
OT  - Energy
OT  - Female
OT  - Reproduction
OT  - Undernutrition
COIS- The authors declare that they have no competing interests.
EDAT- 2021/01/06 06:00
MHDA- 2021/10/15 06:00
PMCR- 2021/01/04
CRDT- 2021/01/05 05:40
PHST- 2020/09/30 00:00 [received]
PHST- 2020/12/06 00:00 [accepted]
PHST- 2021/01/05 05:40 [entrez]
PHST- 2021/01/06 06:00 [pubmed]
PHST- 2021/10/15 06:00 [medline]
PHST- 2021/01/04 00:00 [pmc-release]
AID - 10.1186/s12958-020-00681-1 [pii]
AID - 681 [pii]
AID - 10.1186/s12958-020-00681-1 [doi]
PST - epublish
SO  - Reprod Biol Endocrinol. 2021 Jan 4;19(1):1. doi: 10.1186/s12958-020-00681-1.