PMID- 33398911 OWN - NLM STAT- MEDLINE DCOM- 20210514 LR - 20210514 IS - 1468-3083 (Electronic) IS - 0926-9959 (Linking) VI - 35 IP - 5 DP - 2021 May TI - Line-field confocal optical coherence tomography of basal cell carcinoma: a descriptive study. PG - 1099-1110 LID - 10.1111/jdv.17078 [doi] AB - BACKGROUND: Early diagnosis and subtype classification of basal cell carcinoma (BCC) are crucial to reduce morbidity and optimize treatment. Good accuracy in differentiating BCC from clinical imitators has been achieved with existing diagnostic strategies but lower performance in discriminating BCC subtypes. Line-field confocal optical coherence tomography (LC-OCT) is a new technology able to combine the technical advantages of reflectance confocal microscopy and OCT. OBJECTIVES: To identify and describe LC-OCT criteria associated with BCC and explore their association with BCC subtypes. METHODS: Basal cell carcinoma were imaged with a handheld LC-OCT device before surgical excision. LC-OCT images were retrospectively evaluated by three observers for presence/absence of criteria for BCC. Multivariate logistic regression models were used to find independent predictors of BCC subtypes. RESULTS: Eighty-nine histopathologically proven BCCs were included, of which 66 (74.2%) were pure subtypes [superficial BCC (sBCC): 19/66 (28.8%); nodular BCC (nBCC): 31/66 (47.0%); infiltrative BCC (iBCC): 16/66 (24.2%)]. Lobules, blood vessels and small bright cells within epidermis/lobules were the most frequent criteria for BCC. LC-OCT criteria independently associated with sBCC were presence of hemispheric lobules, absence of lobule separation from the epidermis, absence of stretching of the stroma; with nBCC were presence of macrolobules, absence of lobule connection to the epidermis; and with iBCC were presence of branched lobules. CONCLUSIONS: This was the first study describing the characteristics of BCC under LC-OCT examination. We proposed morphologic criteria, which could be potentially useful for diagnosis and subtype classification of BCC, as well as for its therapeutic management. Future studies are needed to assess these hypotheses. CI - (c) 2020 European Academy of Dermatology and Venereology. FAU - Suppa, M AU - Suppa M AUID- ORCID: 0000-0002-9266-0342 AD - Department of Dermatology, Hopital Erasme, Universite Libre de Bruxelles, Brussels, Belgium. AD - Department of Dermatology, Institut Jules Bordet, Universite Libre de Bruxelles, Brussels, Belgium. FAU - Fontaine, M AU - Fontaine M AD - Department of Dermatology, Hopital Erasme, Universite Libre de Bruxelles, Brussels, Belgium. FAU - Dejonckheere, G AU - Dejonckheere G AD - Department of Dermatology, Hopital Erasme, Universite Libre de Bruxelles, Brussels, Belgium. FAU - Cinotti, E AU - Cinotti E AUID- ORCID: 0000-0002-4009-0659 AD - Dermatology Unit, Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy. FAU - Yelamos, O AU - Yelamos O AUID- ORCID: 0000-0002-8058-3095 AD - Melanoma Unit, Hospital Clinic Barcelona, University of Barcelona, Barcelona, Spain. AD - Dermatology Department, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain. FAU - Diet, G AU - Diet G AD - Department of Dermatology, Hopital Erasme, Universite Libre de Bruxelles, Brussels, Belgium. FAU - Tognetti, L AU - Tognetti L AD - Dermatology Unit, Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy. FAU - Miyamoto, M AU - Miyamoto M AD - Department of Dermatology, Hopital Erasme, Universite Libre de Bruxelles, Brussels, Belgium. FAU - Orte Cano, C AU - Orte Cano C AUID- ORCID: 0000-0002-1570-7856 AD - Department of Dermatology, Hopital Erasme, Universite Libre de Bruxelles, Brussels, Belgium. FAU - Perez-Anker, J AU - Perez-Anker J AD - Melanoma Unit, Hospital Clinic Barcelona, University of Barcelona, Barcelona, Spain. AD - CIBER de enfermedades raras, Instituto de Salud Carlos III, Barcelona, Spain. FAU - Panagiotou, V AU - Panagiotou V AD - Department of Pathology, Hopital Erasme, Universite Libre de Bruxelles, Brussels, Belgium. FAU - Trepant, A L AU - Trepant AL AD - Department of Pathology, Hopital Erasme, Universite Libre de Bruxelles, Brussels, Belgium. FAU - Monnier, J AU - Monnier J AD - Department of Dermatology, AP-HM, Aix-Marseille University, Marseille, France. FAU - Berot, V AU - Berot V AD - Department of Dermatology, University Hospital of Saint-Etienne, Saint-Etienne, France. FAU - Puig, S AU - Puig S AUID- ORCID: 0000-0003-1337-9745 AD - Melanoma Unit, Hospital Clinic Barcelona, University of Barcelona, Barcelona, Spain. AD - CIBER de enfermedades raras, Instituto de Salud Carlos III, Barcelona, Spain. FAU - Rubegni, P AU - Rubegni P AD - Dermatology Unit, Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy. FAU - Malvehy, J AU - Malvehy J AD - Melanoma Unit, Hospital Clinic Barcelona, University of Barcelona, Barcelona, Spain. AD - CIBER de enfermedades raras, Instituto de Salud Carlos III, Barcelona, Spain. FAU - Perrot, J L AU - Perrot JL AD - Department of Dermatology, University Hospital of Saint-Etienne, Saint-Etienne, France. FAU - Del Marmol, V AU - Del Marmol V AD - Department of Dermatology, Hopital Erasme, Universite Libre de Bruxelles, Brussels, Belgium. LA - eng PT - Journal Article DEP - 20201229 PL - England TA - J Eur Acad Dermatol Venereol JT - Journal of the European Academy of Dermatology and Venereology : JEADV JID - 9216037 SB - IM MH - *Carcinoma, Basal Cell/diagnostic imaging MH - Humans MH - Microscopy, Confocal MH - Retrospective Studies MH - *Skin Neoplasms/diagnostic imaging MH - Tomography, Optical Coherence EDAT- 2021/01/06 06:00 MHDA- 2021/05/15 06:00 CRDT- 2021/01/05 06:34 PHST- 2020/10/01 00:00 [revised] PHST- 2020/06/29 00:00 [received] PHST- 2020/10/28 00:00 [accepted] PHST- 2021/01/06 06:00 [pubmed] PHST- 2021/05/15 06:00 [medline] PHST- 2021/01/05 06:34 [entrez] AID - 10.1111/jdv.17078 [doi] PST - ppublish SO - J Eur Acad Dermatol Venereol. 2021 May;35(5):1099-1110. doi: 10.1111/jdv.17078. Epub 2020 Dec 29.