PMID- 33401931
OWN - NLM
STAT- MEDLINE
DCOM- 20210510
LR  - 20210510
IS  - 1940-1574 (Electronic)
IS  - 0003-3197 (Linking)
VI  - 72
IP  - 5
DP  - 2021 May
TI  - Association of Plasma MiRNA-204 and the Presence and Severity of Coronary Artery 
      Calcification in Patients With Type 2 Diabetes.
PG  - 451-458
LID - 10.1177/0003319720984592 [doi]
AB  - We investigated the association between plasma microRNA (miR)-204 and coronary 
      artery calcification (CAC) in patients with type 2 diabetes mellitus (T2DM). We 
      consecutively enrolled 179 individuals with T2DM who underwent coronary computed 
      tomography at Anzhen Hospital from January 2015 to September 2016. The CAC score 
      (CACS) was expressed in Agatston units and >10 Hounsfield units were defined as 
      CAC-positive status. Significant CAC was observed in 98 (54.7%) patients. Plasma 
      miR-204 levels (relative expression) were significantly lower in patients with 
      significant CAC than controls (1.001 +/- 0.100 vs 0.634 +/- 0.211, P < .001). Plasma 
      miR-204 levels were also negatively correlated with the glycosylated hemoglobin 
      A(1c) (HbA(1c)) level (r = -0.702, P < .001), CACS (r = -0.710, P < .001), and 
      the United Kingdom Prospective Diabetes Study (UKPDS) score (r = -0.355, P < 
      .001). After multivariate logistic analyses, plasma miR-204 levels were still 
      significantly and independently associated with the presence of CAC (odds ratio = 
      0.103, CI = 0.018-0.583, P < .001) after adjustment for conventional risk 
      factors. Receiver operating characteristic curve analysis showed that plasma 
      miR-204 levels can predict the severity and extent of CAC, and the specificity 
      was higher than that of the traditional risk factors UKPDS score and HbA(1c). In 
      conclusion, the downregulation of miR-204 was independently associated with CAC 
      in patients with T2DM.
FAU - Ding, Yao-Dong
AU  - Ding YD
AD  - Department of Cardiology, 12667Beijing Anzhen Hospital, Capital Medical 
      University, Beijing, People's Republic of China.
FAU - Pei, Yu-Qiang
AU  - Pei YQ
AD  - Department of Cardiology, 12667Beijing Anzhen Hospital, Capital Medical 
      University, Beijing, People's Republic of China.
FAU - Rui-Wang
AU  - Rui-Wang
AD  - Department of Cardiology, 12667Beijing Anzhen Hospital, Capital Medical 
      University, Beijing, People's Republic of China.
FAU - Yang, Jia-Xin
AU  - Yang JX
AD  - Department of Cardiology, 12667Beijing Anzhen Hospital, Capital Medical 
      University, Beijing, People's Republic of China.
FAU - Zhao, Ying-Xin
AU  - Zhao YX
AUID- ORCID: 0000-0002-4897-2779
AD  - Department of Cardiology, 12667Beijing Anzhen Hospital, Capital Medical 
      University, Beijing, People's Republic of China.
FAU - Liu, Xiao-Li
AU  - Liu XL
AD  - Department of Cardiology, 12667Beijing Anzhen Hospital, Capital Medical 
      University, Beijing, People's Republic of China.
FAU - Shen, Hua
AU  - Shen H
AD  - Department of Cardiology, 12667Beijing Anzhen Hospital, Capital Medical 
      University, Beijing, People's Republic of China.
FAU - Ma, Qian
AU  - Ma Q
AD  - Department of Cardiology, 12667Beijing Anzhen Hospital, Capital Medical 
      University, Beijing, People's Republic of China.
FAU - Zhang, Shuo
AU  - Zhang S
AD  - 105738Beijing Tiantan Hospital, Capital Medical University, Beijing, People's 
      Republic of China.
FAU - Ge, Hai-Long
AU  - Ge HL
AUID- ORCID: 0000-0002-8148-2835
AD  - Department of Cardiology, 12667Beijing Anzhen Hospital, Capital Medical 
      University, Beijing, People's Republic of China.
LA  - eng
PT  - Journal Article
DEP - 20210105
PL  - United States
TA  - Angiology
JT  - Angiology
JID - 0203706
RN  - 0 (Biomarkers)
RN  - 0 (Circulating MicroRNA)
RN  - 0 (MIRN204 microRNA, human)
RN  - 0 (MicroRNAs)
SB  - IM
MH  - Aged
MH  - Beijing
MH  - Biomarkers/blood
MH  - Circulating MicroRNA/*blood
MH  - Coronary Angiography
MH  - Coronary Artery Disease/*blood/complications/diagnostic imaging
MH  - Diabetes Mellitus, Type 2/*blood/complications/diagnosis
MH  - Down-Regulation
MH  - Female
MH  - Humans
MH  - Male
MH  - MicroRNAs/*blood
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - Retrospective Studies
MH  - Risk Assessment
MH  - Risk Factors
MH  - Severity of Illness Index
MH  - Vascular Calcification/*blood/complications/diagnostic imaging
OTO - NOTNLM
OT  - calcification
OT  - coronary artery disease
OT  - coronary computed tomography
OT  - miRNA-204
OT  - type 2 diabetes mellitus
EDAT- 2021/01/07 06:00
MHDA- 2021/05/11 06:00
CRDT- 2021/01/06 05:28
PHST- 2021/01/07 06:00 [pubmed]
PHST- 2021/05/11 06:00 [medline]
PHST- 2021/01/06 05:28 [entrez]
AID - 10.1177/0003319720984592 [doi]
PST - ppublish
SO  - Angiology. 2021 May;72(5):451-458. doi: 10.1177/0003319720984592. Epub 2021 Jan 
      5.