PMID- 33402410
OWN - NLM
STAT- MEDLINE
DCOM- 20210514
LR  - 20240330
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 11
IP  - 1
DP  - 2021 Jan 5
TI  - Cross-sectional study examining the status of intrinsic capacity decline in 
      community-dwelling older adults in China: prevalence, associated factors and 
      implications for clinical care.
PG  - e043062
LID - 10.1136/bmjopen-2020-043062 [doi]
LID - e043062
AB  - OBJECTIVES: Intrinsic capacity (IC) was proposed by the WHO as a new concept for 
      capturing an individual's functional capacities across their lifetime. We aimed 
      to investigate the prevalence and factors associated with IC decline and examine 
      associations between IC and adverse outcomes among community-dwelling older 
      adults in China. DESIGN: A cross-sectional study. SETTING: Community, China. 
      PARTICIPANTS: Data were derived from the China Comprehensive Geriatric Assessment 
      Study, a population-based nationally representative sample. IC comprises of five 
      domains: locomotion, cognition, vitality, sensory and psychology. Participants 
      were deemed to have IC decline if they showed a decline in any of the five 
      domains. Sociodemographic characteristics, chronic diseases, geriatric syndromes 
      and adverse outcomes were also examined. RESULTS: Of the 5823 community-dwelling 
      participants aged 60-98 years, 2506 had IC decline (weighted 39.9%): 57.7% in 
      western, 38.3% in northern, 33.7% in northwest, 36.1% in middle, 16.9% in eastern 
      and 19.8% in northeast China. The number of participants with decline in the 
      locomotion, cognition, vitality, sensory and psychological domains were 1039 
      (17.8%), 646 (11.1%), 735 (12.6%), 824 (14.2%) and 713 (12.2%), respectively. 
      Age, northern residence, low education, being unmarried, low income, less 
      exercise, less meat intake, insomnia, memory loss, urinary incontinence, 
      constipation, slowness, chronic obstructive pulmonary disease and osteoarthritis 
      were related to IC decline. After adjusting for age, sex, area, district, 
      marriage, education, waist-hip ratio, smoking, alcohol consumption, exercise, 
      income and chronic diseases, IC decline was independently associated with risk of 
      frailty, disability, falls, fractures and immobility. CONCLUSION: The prevalence 
      of IC decline in China is high. IC decline was significantly associated with 
      adverse outcomes, after adjustment for related variables. Efforts promoting IC to 
      delay functional dependence should focus on modifiable factors, including 
      negative social factors, poor lifestyle, chronic diseases and geriatric 
      syndromes.
CI  - (c) Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No 
      commercial re-use. See rights and permissions. Published by BMJ.
FAU - Ma, Lina
AU  - Ma L
AUID- ORCID: 0000-0001-7630-6960
AD  - Department of Geriatrics, Xuanwu Hospital, Capital Medical University, China 
      National Clinical Research Center for Geriatric Disorders, Beijing, China 
      malina0883@126.com tangzhe@sina.com.
FAU - Chhetri, Jagadish K
AU  - Chhetri JK
AD  - Department of Geriatrics, Xuanwu Hospital, Capital Medical University, China 
      National Clinical Research Center for Geriatric Disorders, Beijing, China.
FAU - Zhang, Li
AU  - Zhang L
AD  - Department of Geriatrics, Xuanwu Hospital, Capital Medical University, China 
      National Clinical Research Center for Geriatric Disorders, Beijing, China.
FAU - Sun, Fei
AU  - Sun F
AD  - Beijing Institute of Geriatrics, Xuanwu Hospital, Capital Medical University, 
      Beijing, China.
FAU - Li, Yun
AU  - Li Y
AD  - Department of Geriatrics, Xuanwu Hospital, Capital Medical University, China 
      National Clinical Research Center for Geriatric Disorders, Beijing, China.
FAU - Tang, Zhe
AU  - Tang Z
AD  - Beijing Institute of Geriatrics, Xuanwu Hospital, Capital Medical University, 
      Beijing, China malina0883@126.com tangzhe@sina.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210105
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - China/epidemiology
MH  - Cross-Sectional Studies
MH  - Frail Elderly
MH  - *Frailty
MH  - Geriatric Assessment
MH  - Humans
MH  - *Independent Living
MH  - Middle Aged
MH  - Prevalence
PMC - PMC7786809
OTO - NOTNLM
OT  - epidemiology
OT  - general medicine (see internal medicine)
OT  - geriatric medicine
COIS- Competing interests: None declared.
EDAT- 2021/01/07 06:00
MHDA- 2021/05/15 06:00
PMCR- 2021/01/05
CRDT- 2021/01/06 05:38
PHST- 2021/01/06 05:38 [entrez]
PHST- 2021/01/07 06:00 [pubmed]
PHST- 2021/05/15 06:00 [medline]
PHST- 2021/01/05 00:00 [pmc-release]
AID - bmjopen-2020-043062 [pii]
AID - 10.1136/bmjopen-2020-043062 [doi]
PST - epublish
SO  - BMJ Open. 2021 Jan 5;11(1):e043062. doi: 10.1136/bmjopen-2020-043062.