PMID- 33402510
OWN - NLM
STAT- MEDLINE
DCOM- 20210618
LR  - 20210618
IS  - 1791-7549 (Electronic)
IS  - 0258-851X (Print)
IS  - 0258-851X (Linking)
VI  - 35
IP  - 1
DP  - 2021 Jan-Feb
TI  - Effect of Prognostic Nutrition Index in Gastric or Gastro-oesophageal Junction 
      Cancer Patients Undergoing Nivolumab Monotherapy.
PG  - 563-569
LID - 10.21873/invivo.12292 [doi]
AB  - BACKGROUND/AIM: We hypothesised that the prognostic nutrition index (PNI) is 
      useful for evaluating host immunity and response to immune checkpoint inhibitors. 
      We investigated the effect of PNI on nivolumab monotherapy efficacy in advanced 
      or recurrent gastric cancer (GC) or gastro-oesophageal junction cancer (GOC) 
      patients. PATIENTS AND METHODS: We retrospectively examined 110 patients, divided 
      them into a high-PNI group and a low-PNI group, and compared treatment efficacy, 
      adverse events (AEs), and survival between the groups. RESULTS: Median overall 
      survival (OS) was significantly longer in the high-PNI group than in the low-PNI 
      group (205 vs. 109 days; p<0.001). Multivariate analysis revealed that low PNI 
      was an independent risk factor for OS (hazard ratio=2.398; 95% confidence 
      interval=1.384-4.154; p=0.002). The overall response rate and frequency of AEs 
      were not significantly different between the groups. CONCLUSION: PNI could be a 
      useful prognostic factor in GC or GOC patients undergoing nivolumab monotherapy.
CI  - Copyright(c) 2021, International Institute of Anticancer Research (Dr. George J. 
      Delinasios), All rights reserved.
FAU - Watanabe, Hayato
AU  - Watanabe H
AD  - Department of Gastrointestinal Surgery, Kanagawa Cancer Centre, Yokohama, Japan.
FAU - Yamada, Takanobu
AU  - Yamada T
AD  - Department of Gastrointestinal Surgery, Kanagawa Cancer Centre, Yokohama, Japan; 
      oshimat@kcch.jp takay0218@yahoo.co.jp.
FAU - Komori, Keisuke
AU  - Komori K
AD  - Department of Gastrointestinal Surgery, Kanagawa Cancer Centre, Yokohama, Japan.
FAU - Hara, Kentaro
AU  - Hara K
AD  - Department of Surgery, Yokohama City University, Yokohama, Japan.
FAU - Kano, Kazuki
AU  - Kano K
AD  - Department of Gastrointestinal Surgery, Kanagawa Cancer Centre, Yokohama, Japan.
FAU - Takahashi, Kosuke
AU  - Takahashi K
AD  - Department of Gastrointestinal Surgery, Kanagawa Cancer Centre, Yokohama, Japan.
FAU - Kumazu, Yuta
AU  - Kumazu Y
AD  - Department of Surgery, Yokohama City University, Yokohama, Japan.
FAU - Fujikawa, Hirohito
AU  - Fujikawa H
AD  - Department of Gastrointestinal Surgery, Kanagawa Cancer Centre, Yokohama, Japan.
FAU - Numata, Masakatsu
AU  - Numata M
AD  - Department of Surgery, Yokohama City University, Yokohama, Japan.
FAU - Aoyama, Toru
AU  - Aoyama T
AD  - Department of Surgery, Yokohama City University, Yokohama, Japan.
FAU - Tamagawa, Hiroshi
AU  - Tamagawa H
AD  - Department of Surgery, Yokohama City University, Yokohama, Japan.
FAU - Inokuchi, Yasuhiro
AU  - Inokuchi Y
AD  - Department of Gastroenterology, Kanagawa Cancer Centre, Yokohama, Japan.
FAU - Machida, Nozomu
AU  - Machida N
AD  - Department of Gastroenterology, Kanagawa Cancer Centre, Yokohama, Japan.
FAU - Shiozawa, Manabu
AU  - Shiozawa M
AD  - Department of Gastrointestinal Surgery, Kanagawa Cancer Centre, Yokohama, Japan.
FAU - Yukawa, Norio
AU  - Yukawa N
AD  - Department of Surgery, Yokohama City University, Yokohama, Japan.
FAU - Morinaga, Soichiro
AU  - Morinaga S
AD  - Department of Gastrointestinal Surgery, Kanagawa Cancer Centre, Yokohama, Japan.
FAU - Rino, Yasushi
AU  - Rino Y
AD  - Department of Surgery, Yokohama City University, Yokohama, Japan.
FAU - Masuda, Munetaka
AU  - Masuda M
AD  - Department of Surgery, Yokohama City University, Yokohama, Japan.
FAU - Ogata, Takashi
AU  - Ogata T
AD  - Department of Gastrointestinal Surgery, Kanagawa Cancer Centre, Yokohama, Japan.
FAU - Oshima, Takashi
AU  - Oshima T
AD  - Department of Gastrointestinal Surgery, Kanagawa Cancer Centre, Yokohama, Japan; 
      oshimat@kcch.jp takay0218@yahoo.co.jp.
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - In Vivo
JT  - In vivo (Athens, Greece)
JID - 8806809
RN  - 31YO63LBSN (Nivolumab)
SB  - IM
MH  - Humans
MH  - Neoplasm Recurrence, Local
MH  - *Nivolumab/adverse effects
MH  - Nutrition Assessment
MH  - Prognosis
MH  - Retrospective Studies
MH  - *Stomach Neoplasms/drug therapy
PMC - PMC7880786
OTO - NOTNLM
OT  - Prognostic nutrition index
OT  - gastric cancer
OT  - gastro-oesophageal junction cancer
OT  - nivolumab
COIS- All Authors have no conflicts of interest or financial ties to disclose in 
      relation to this study.
EDAT- 2021/01/07 06:00
MHDA- 2021/06/22 06:00
PMCR- 2021/01/03
CRDT- 2021/01/06 05:39
PHST- 2020/10/20 00:00 [received]
PHST- 2020/11/04 00:00 [revised]
PHST- 2020/11/08 00:00 [accepted]
PHST- 2021/01/06 05:39 [entrez]
PHST- 2021/01/07 06:00 [pubmed]
PHST- 2021/06/22 06:00 [medline]
PHST- 2021/01/03 00:00 [pmc-release]
AID - 35/1/563 [pii]
AID - 10.21873/invivo.12292 [doi]
PST - ppublish
SO  - In Vivo. 2021 Jan-Feb;35(1):563-569. doi: 10.21873/invivo.12292.