PMID- 33402917
OWN - NLM
STAT- MEDLINE
DCOM- 20210222
LR  - 20221207
IS  - 1729-0503 (Electronic)
IS  - 1680-6905 (Print)
IS  - 1680-6905 (Linking)
VI  - 20
IP  - 1
DP  - 2020 Mar
TI  - Trace elements in type 2 diabetes mellitus and their association with glycemic 
      control.
PG  - 287-293
LID - 10.4314/ahs.v20i1.34 [doi]
AB  - BACKGROUND: Alterations in serum levels of trace elements reported in type 2 
      diabetes mellitus (T2DM) have been linked with induction of T2DM and associated 
      complications. OBJECTIVES: To assess serum levels of copper (Cu), zinc (Zn) and 
      selenium (Se) in T2DM patients with adequate and poor glycemic control. PATIENTS 
      AND METHODS: This study was performed at King Khalid University Hospital, Riyadh. 
      A total of 100 consenting T2DM patients comprising of 50 patients with glycated 
      hemoglobin (HbA1c) less than 6.5% and 50 patients with HbA1c more than 6.5% along 
      with a group of 50 normal healthy individuals were included in the study. Serum 
      levels of Cu, Zn and Se were measured by inductively coupled plasma-mass 
      spectrometry (ICP-MS) instrument. RESULTS: Among T2DM patients with HbA1c <6.5%, 
      mean serum Cu levels (13.4+4.3micromol/L) were not different from the controls 
      (14.5+1.92micromol/L) whereas Zn (9.9+2.7micromol/Lvs15+3.2micromol/L;p<0.0001) and Se levels 
      (1+0.2micromol/Lvs1.62+0.2micromol/L; p<0.0004) were lower than the controls. Among T2DM 
      patients with HbA1c >6.5% mean serum Cu (18.1+4.1micromol/Lvs14.5+1.9micromol/L; 
      p<0.0001), Zn (15+3.2micromol/Lvs13.5+1.9micromol/L; p<0.009) and Se 
      (1.62+0.2micromol/Lvs1.17+0.16micromol/L;p<0.0001) were significantly higher than the 
      controls. HbA1c% negatively correlated with HbA1c >6.5% (r = -0.302; p<0.03). 
      CONCLUSION: Cu, Zn and Se homeostasis was altered in T2DM patients and varied 
      with glycemic control.
CI  - (c) 2020 Hasanato RMW.
FAU - Hasanato, Rana Mw
AU  - Hasanato RM
AD  - Department of Pathology, College of Medicine and University Hospitals, King Saud 
      University, Riyadh, Kingdom of Saudi Arabia.
LA  - eng
PT  - Journal Article
PL  - Uganda
TA  - Afr Health Sci
JT  - African health sciences
JID - 101149451
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Trace Elements)
RN  - 789U1901C5 (Copper)
RN  - H6241UJ22B (Selenium)
RN  - J41CSQ7QDS (Zinc)
SB  - IM
MH  - Adult
MH  - Blood Glucose/metabolism
MH  - Case-Control Studies
MH  - Copper/blood/*metabolism
MH  - Diabetes Mellitus/blood/*metabolism
MH  - Diabetes Mellitus, Type 2/blood/*metabolism
MH  - Female
MH  - Glycated Hemoglobin/*metabolism
MH  - Glycemic Control
MH  - Humans
MH  - Insulin Resistance
MH  - Male
MH  - Middle Aged
MH  - Selenium/blood
MH  - Trace Elements/*blood
MH  - Zinc/blood/*metabolism
PMC - PMC7750058
OTO - NOTNLM
OT  - Copper
OT  - Selenium
OT  - Zinc
OT  - diabetes mellitus
OT  - trace elements
EDAT- 2021/01/07 06:00
MHDA- 2021/02/23 06:00
PMCR- 2020/03/01
CRDT- 2021/01/06 05:52
PHST- 2021/01/06 05:52 [entrez]
PHST- 2021/01/07 06:00 [pubmed]
PHST- 2021/02/23 06:00 [medline]
PHST- 2020/03/01 00:00 [pmc-release]
AID - jAFHS.v20.i1.pg287 [pii]
AID - 10.4314/ahs.v20i1.34 [doi]
PST - ppublish
SO  - Afr Health Sci. 2020 Mar;20(1):287-293. doi: 10.4314/ahs.v20i1.34.