PMID- 33403526
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210115
IS  - 2045-9769 (Print)
IS  - 2045-9769 (Electronic)
IS  - 2045-9769 (Linking)
VI  - 10
IP  - 1
DP  - 2021 Jan 6
TI  - All routes lead to Rome: multifaceted origin of hepatocytes during liver 
      regeneration.
PG  - 2
LID - 10.1186/s13619-020-00063-3 [doi]
LID - 2
AB  - Liver is the largest internal organ that serves as the key site for various 
      metabolic activities and maintenance of homeostasis. Liver diseases are great 
      threats to human health. The capability of liver to regain its mass after partial 
      hepatectomy has widely been applied in treating liver diseases either by removing 
      the damaged part of a diseased liver in a patient or transplanting a part of 
      healthy liver into a patient. Vast efforts have been made to study the biology of 
      liver regeneration in different liver-damage models. Regarding the sources of 
      hepatocytes during liver regeneration, convincing evidences have demonstrated 
      that different liver-damage models mobilized different subtype hepatocytes in 
      contributing to liver regeneration. Under extreme hepatocyte ablation, biliary 
      epithelial cells can undergo dedifferentiation to liver progenitor cells (LPCs) 
      and then LPCs differentiate to produce hepatocytes. Here we will focus on 
      summarizing the progresses made in identifying cell types contributing to 
      producing new hepatocytes during liver regeneration in mice and zebrafish.
FAU - Gao, Ce
AU  - Gao C
AD  - MOE Key Laboratory for Molecular Animal Nutrition, College of Animal Sciences, 
      Zhejiang University, Hangzhou, 310058, China.
FAU - Peng, Jinrong
AU  - Peng J
AD  - MOE Key Laboratory for Molecular Animal Nutrition, College of Animal Sciences, 
      Zhejiang University, Hangzhou, 310058, China. pengjr@zju.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20210106
PL  - China
TA  - Cell Regen
JT  - Cell regeneration (London, England)
JID - 101627311
PMC - PMC7785766
COIS- The authors declare that they have no competing interests.
EDAT- 2021/01/07 06:00
MHDA- 2021/01/07 06:01
PMCR- 2021/01/06
CRDT- 2021/01/06 05:56
PHST- 2020/06/21 00:00 [received]
PHST- 2020/09/09 00:00 [accepted]
PHST- 2021/01/06 05:56 [entrez]
PHST- 2021/01/07 06:00 [pubmed]
PHST- 2021/01/07 06:01 [medline]
PHST- 2021/01/06 00:00 [pmc-release]
AID - 10.1186/s13619-020-00063-3 [pii]
AID - 63 [pii]
AID - 10.1186/s13619-020-00063-3 [doi]
PST - epublish
SO  - Cell Regen. 2021 Jan 6;10(1):2. doi: 10.1186/s13619-020-00063-3.