PMID- 33403891
OWN - NLM
STAT- MEDLINE
DCOM- 20211005
LR  - 20211005
IS  - 2162-397X (Electronic)
IS  - 2162-3945 (Print)
IS  - 2162-3945 (Linking)
VI  - 10
IP  - 1
DP  - 2021 Dec
TI  - Brown and beige adipose tissue: a novel therapeutic strategy for obesity and type 
      2 diabetes mellitus.
PG  - 48-65
LID - 10.1080/21623945.2020.1870060 [doi]
AB  - Mammalian adipose tissue can be divided into two major types, namely, white 
      adipose tissue (WAT) and brown adipose tissue (BAT). According to classical view, 
      the main function of WAT is to store excess energy in the form of triglycerides, 
      while BAT is a thermogenic tissue that acts a pivotal part in maintaining the 
      core body temperature. White adipocytes display high plasticity and can 
      transdifferentiate into beige adipocytes which have many similar morphological 
      and functional properties with brown adipocytes under the stimulations of 
      exercise, cold exposure and other factors. This phenomenon is also known as 
      'browning of WAT'. In addition to transdifferentiation, beige adipocytes can also 
      come from de novo differentiation from tissue-resident progenitors. Activating 
      BAT and inducing browning of WAT can accelerate the intake of glycolipids and 
      reduce the insulin secretion requirement, which may be a new strategy to improve 
      glycolipids metabolism and insulin resistance of obese and type 2 diabetes 
      mellitus (T2DM) patients. This review mainly discusses the significance of brown 
      and beige adipose tissues in the treatment of obesity and T2DM, and focuses on 
      the effect of the browning agent on obesity and T2DM, which provides a brand-new 
      theoretical reference for the prevention and treatment of obesity and T2DM.
FAU - Cheng, Long
AU  - Cheng L
AD  - Department of Pharmacology, School of Chinese Materia Medica, Beijing University 
      of Chinese Medicine , Beijing China.
FAU - Wang, Jingkang
AU  - Wang J
AD  - Department of Pharmacology, School of Chinese Materia Medica, Beijing University 
      of Chinese Medicine , Beijing China.
FAU - Dai, Hongyu
AU  - Dai H
AD  - Department of Pharmacology, School of Chinese Materia Medica, Beijing University 
      of Chinese Medicine , Beijing China.
FAU - Duan, Yuhui
AU  - Duan Y
AD  - Department of Pharmacology, School of Chinese Materia Medica, Beijing University 
      of Chinese Medicine , Beijing China.
FAU - An, Yongcheng
AU  - An Y
AD  - College of Life Sciences, Beijing University of Chinese Medicine , Beijing, 
      China.
FAU - Shi, Lu
AU  - Shi L
AD  - Department of Pharmacology, School of Chinese Materia Medica, Beijing University 
      of Chinese Medicine , Beijing China.
FAU - Lv, Yinglan
AU  - Lv Y
AD  - Department of Pharmacology, School of Chinese Materia Medica, Beijing University 
      of Chinese Medicine , Beijing China.
FAU - Li, Huimin
AU  - Li H
AD  - Department of Pharmacology, School of Chinese Materia Medica, Beijing University 
      of Chinese Medicine , Beijing China.
FAU - Wang, Chen
AU  - Wang C
AD  - College of Life Sciences, Beijing University of Chinese Medicine , Beijing, 
      China.
FAU - Ma, Quantao
AU  - Ma Q
AD  - Department of Pharmacology, School of Chinese Materia Medica, Beijing University 
      of Chinese Medicine , Beijing China.
FAU - Li, Yaqi
AU  - Li Y
AD  - Department of Pharmacology, School of Chinese Materia Medica, Beijing University 
      of Chinese Medicine , Beijing China.
FAU - Li, Pengfei
AU  - Li P
AD  - Department of Pharmacology, School of Chinese Materia Medica, Beijing University 
      of Chinese Medicine , Beijing China.
FAU - Du, Haifeng
AU  - Du H
AD  - The Third Municipal Hospital of Chengde , Chengde, China.
FAU - Zhao, Baosheng
AU  - Zhao B
AD  - Beijing Research Institute of Chinese Medicine, Beijing University of Chinese 
      Medicine , Beijing China.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Adipocyte
JT  - Adipocyte
JID - 101567863
SB  - IM
MH  - Adipocytes, Beige/metabolism
MH  - Adipocytes, Brown/metabolism
MH  - Adipocytes, White/metabolism
MH  - Adipose Tissue/*metabolism
MH  - Adipose Tissue, Beige/metabolism
MH  - Adipose Tissue, Brown/metabolism
MH  - Adipose Tissue, White/metabolism
MH  - Cell Transdifferentiation
MH  - Diabetes Mellitus, Type 2/metabolism/*therapy
MH  - Energy Metabolism
MH  - Humans
MH  - Insulin Resistance
MH  - Obesity/metabolism/*therapy
MH  - Thermogenesis
PMC - PMC7801117
OTO - NOTNLM
OT  - Brown adipose tissue
OT  - beige adipose tissue
OT  - browning of white adipose tissue
OT  - obesity
OT  - type 2 diabetes mellitus
OT  - white adipose tissue
COIS- The authors declare that they have no competing interest.
EDAT- 2021/01/07 06:00
MHDA- 2021/10/06 06:00
PMCR- 2021/01/06
CRDT- 2021/01/06 08:40
PHST- 2021/01/06 08:40 [entrez]
PHST- 2021/01/07 06:00 [pubmed]
PHST- 2021/10/06 06:00 [medline]
PHST- 2021/01/06 00:00 [pmc-release]
AID - 1870060 [pii]
AID - 10.1080/21623945.2020.1870060 [doi]
PST - ppublish
SO  - Adipocyte. 2021 Dec;10(1):48-65. doi: 10.1080/21623945.2020.1870060.