PMID- 3340392
OWN - NLM
STAT- MEDLINE
DCOM- 19880309
LR  - 20180216
IS  - 0030-2414 (Print)
IS  - 0030-2414 (Linking)
VI  - 45
IP  - 1
DP  - 1988
TI  - Comparison of photodynamic inactivation of experimental stomach tumors sensitized 
      by acridine orange or hematoporphyrin derivatives.
PG  - 35-40
AB  - The photodynamic inactivations of Walker carcinosarcoma 256 stomach tumors by the 
      concomitant use of acridine orange (AO) and argon laser, and by the combined use 
      of hematoporphyrin derivatives (HPD) and dye laser were compared. Wistar rats 
      bearing stomach tumors of 4-6 mm in diameter 5-10 days after their implantation 
      were injected intraperitoneally with 40 mg/kg body weight of AO or HPD, and 24 h 
      later their stomach tumors were exposed to argon laser at 488 nm or dye laser at 
      630 nm, respectively, at an intensity of 15 mW/cm2 for 20 min. Temperature rise 
      was less than 3 degrees C during irradiation. Seven days after irradiation, 
      complete or partial necrosis with sparing of the surrounding mucosa was seen 
      histologically in all rats treated by the two therapy methods. Phase contrast and 
      electron microscopy showed nuclear pyknosis and damage to the inner layer of the 
      nuclear envelope in tumor cells treated with AO and argon laser, while 
      cytotoxicity involved damage to the outer layer of the nuclear envelope and 
      intracytoplasmic organelles in tumor cells treated with HPD and dye laser. This 
      difference between AO and HPD is considered to be a difference in their 
      intracellular localization in tumor cells.
FAU - Tatsuta, M
AU  - Tatsuta M
AD  - Department of Gastrointestinal Oncology, Center for Adult Diseases, Osaka, Japan.
FAU - Iishi, H
AU  - Iishi H
FAU - Yamamura, H
AU  - Yamamura H
FAU - Yamamoto, R
AU  - Yamamoto R
FAU - Okuda, S
AU  - Okuda S
LA  - eng
PT  - Journal Article
PL  - Switzerland
TA  - Oncology
JT  - Oncology
JID - 0135054
RN  - 0 (Hematoporphyrins)
RN  - F30N4O6XVV (Acridine Orange)
SB  - IM
MH  - Acridine Orange/*therapeutic use
MH  - Animals
MH  - Carcinoma 256, Walker/pathology/*therapy
MH  - Hematoporphyrin Photoradiation
MH  - Hematoporphyrins
MH  - Lasers
MH  - Microscopy, Electron
MH  - Photochemotherapy/*methods
MH  - Rats
MH  - Stomach Neoplasms/pathology/therapy
EDAT- 1988/01/01 00:00
MHDA- 1988/01/01 00:01
CRDT- 1988/01/01 00:00
PHST- 1988/01/01 00:00 [pubmed]
PHST- 1988/01/01 00:01 [medline]
PHST- 1988/01/01 00:00 [entrez]
AID - 10.1159/000226527 [doi]
PST - ppublish
SO  - Oncology. 1988;45(1):35-40. doi: 10.1159/000226527.