PMID- 33404062
OWN - NLM
STAT- MEDLINE
DCOM- 20211210
LR  - 20211214
IS  - 1795-990X (Electronic)
IS  - 0355-3140 (Print)
IS  - 0355-3140 (Linking)
VI  - 47
IP  - 4
DP  - 2021 May 1
TI  - Is job strain associated with a higher risk of type 2 diabetes mellitus? A 
      systematic review and meta-analysis of prospective cohort studies.
PG  - 249-257
LID - 3938 [pii]
LID - 10.5271/sjweh.3938 [doi]
AB  - OBJECTIVES: Epidemiological studies have explored the relationship between 
      work-related stress and the risk of type 2 diabetes mellitus (T2DM), but it 
      remains unclear on whether work-related stress could increase the risk of T2DM. 
      We aimed to evaluate the association between job strain and the risk of T2DM. 
      METHODS: We searched PubMed and Web of Science up to April 2019. Summary risk 
      estimates were calculated by random-effect models. And the analysis was also 
      conducted stratifying by gender, study location, smoking, drinking, body mass 
      index, physical activity, family history of T2DM, education and T2DM 
      ascertainment. Studies with binary job strain and quadrants based on the job 
      strain model were analyzed separately. RESULTS: A total of nine studies with 210 
      939 participants free of T2DM were included in this analysis. High job strain 
      (high job demands and low control) was associated with the overall risk of T2DM 
      compared with no job strain (all other combinations) [relative risk (RR) 1.16, 
      95% confidence interval (CI) 1.03-1.31], and the association was more evident in 
      women (RR 1.48, 95% CI 1.02-2.14). A statistically significant association was 
      also observed when using high strain as a category (job strain quadrants) rather 
      than binary variable (RR 1.62, 95% CI 1.04-2.55) in women but not men. 
      CONCLUSIONS: Our study suggests that job strain is an important risk factor for 
      T2DM, especially among women. Appropriate preventive interventions in populations 
      with high job strain would contribute to a reduction in T2DM risk.
FAU - Li, Wenzhen
AU  - Li W
AD  - Department of Occupational & Environmental Health, School of Public Health, 
      Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 
      Hubei, China. 648283002@qq.com.
FAU - Yi, Guilin
AU  - Yi G
FAU - Chen, Zhenlong
AU  - Chen Z
FAU - Dai, Xiayun
AU  - Dai X
FAU - Wu, Jie
AU  - Wu J
FAU - Peng, Ying
AU  - Peng Y
FAU - Ruan, Wenyu
AU  - Ruan W
FAU - Lu, Zuxun
AU  - Lu Z
FAU - Wang, Dongming
AU  - Wang D
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PT  - Systematic Review
DEP - 20210106
PL  - Finland
TA  - Scand J Work Environ Health
JT  - Scandinavian journal of work, environment & health
JID - 7511540
SB  - IM
MH  - Body Mass Index
MH  - *Diabetes Mellitus, Type 2/epidemiology/etiology
MH  - Female
MH  - Humans
MH  - Prospective Studies
MH  - Risk Factors
PMC - PMC8091067
COIS- The authors declare no conflicts of interest.
EDAT- 2021/01/07 06:00
MHDA- 2021/12/15 06:00
PMCR- 2021/05/01
CRDT- 2021/01/06 08:50
PHST- 2021/01/07 06:00 [pubmed]
PHST- 2021/12/15 06:00 [medline]
PHST- 2021/01/06 08:50 [entrez]
PHST- 2021/05/01 00:00 [pmc-release]
AID - 3938 [pii]
AID - 10.5271/sjweh.3938 [doi]
PST - ppublish
SO  - Scand J Work Environ Health. 2021 May 1;47(4):249-257. doi: 10.5271/sjweh.3938. 
      Epub 2021 Jan 6.