PMID- 33405645
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210106
IS  - 2373-9878 (Electronic)
IS  - 2373-9878 (Linking)
VI  - 5
IP  - 3
DP  - 2019 Mar 11
TI  - Preparation of Graphene Oxide-Doped Polypyrrole Composite Films with Stable 
      Conductivity and Their Effect on the Elongation and Alignment of Neurite.
PG  - 1268-1278
LID - 10.1021/acsbiomaterials.8b01326 [doi]
AB  - Conductive composite films (CCFs) of polypyrrole (PPy) doped with sodium dodecyl 
      benzenesulfonate (DBS) and graphene oxide (GO) were prepared via electrochemical 
      deposition of PPy nanoparticles on the aligned PLLA fibers. The doping amount of 
      GO in CCF sheaths reached to  approximately 3.8%, leading to  approximately 32 S cm(-1) of the mean 
      conductivity of DBS-GO-doped CCF. The electrical potential image of DBS-GO-doped 
      CCFs showed that the charges were mainly distributed on the tops of GO sheets 
      protruded from the PPy surface. The immersion results indicated that the more 
      stable conductivity of DBS-GO-doped CCF resulted from the reservation of GO 
      sheets in the PPy film because of the van der Waals's force between GO and the 
      pyrrole rings in CCF sheath. The results of PC12 cell test showed that, the 
      rougher surface of DBS-GO-doped CCF could positively affect the neurite 
      elongation due to the slight protrusion of GO sheets from the CCF surface. The 
      electrical stimulation (ES) of 50 mV cm(-1) through DBS-GO-doped CCF could 
      significantly promote neurite elongation and alignment, as well  approximately 149 mum of the 
      mean neurite length and 70% of alignment on DBS-GO-doped CCF were significantly 
      higher than those without ES, respectively. These results indicated that the more 
      stable conductivity of DBS-GO-doped CCF could enhance the ES efficiency on the 
      elongation and alignment of neurites, due to the more charges accumulation on the 
      tops of the protruded GO sheets in the CCF surface. A mechanism was proposed to 
      explain the positive effect of the GO-nanosheets protrusion, rougher PPy surface 
      and stable conductivity on the elongation and alignment of neurites. These 
      results suggested the possibilities for the long-term peripheral nerve repair in 
      vivo via ES through DBS-GO-doped CCF.
FAU - Shang, Lei
AU  - Shang L
AD  - College of Materials Science and Engineering, Sichuan University, Chengdu 610065, 
      China.
FAU - Huang, Zhongbing
AU  - Huang Z
AUID- ORCID: 0000-0001-9210-1842
AD  - College of Materials Science and Engineering, Sichuan University, Chengdu 610065, 
      China.
FAU - Pu, Ximing
AU  - Pu X
AD  - College of Materials Science and Engineering, Sichuan University, Chengdu 610065, 
      China.
FAU - Yin, Guangfu
AU  - Yin G
AD  - College of Materials Science and Engineering, Sichuan University, Chengdu 610065, 
      China.
FAU - Chen, Xianchun
AU  - Chen X
AD  - College of Materials Science and Engineering, Sichuan University, Chengdu 610065, 
      China.
LA  - eng
PT  - Journal Article
DEP - 20190205
PL  - United States
TA  - ACS Biomater Sci Eng
JT  - ACS biomaterials science & engineering
JID - 101654670
SB  - IM
OTO - NOTNLM
OT  - dopant
OT  - electrical stimulation
OT  - graphene-oxide sheet
OT  - neurite growth
OT  - polypyrrole composite
EDAT- 2019/03/11 00:00
MHDA- 2019/03/11 00:01
CRDT- 2021/01/06 17:10
PHST- 2021/01/06 17:10 [entrez]
PHST- 2019/03/11 00:00 [pubmed]
PHST- 2019/03/11 00:01 [medline]
AID - 10.1021/acsbiomaterials.8b01326 [doi]
PST - ppublish
SO  - ACS Biomater Sci Eng. 2019 Mar 11;5(3):1268-1278. doi: 
      10.1021/acsbiomaterials.8b01326. Epub 2019 Feb 5.