PMID- 33405770
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210106
IS  - 2373-9878 (Electronic)
IS  - 2373-9878 (Linking)
VI  - 5
IP  - 5
DP  - 2019 May 13
TI  - Supramolecular Gels Derived from Simple Organic Salts of Flufenamic Acid: Design, 
      Synthesis, Structures, and Plausible Biomedical Application.
PG  - 2180-2189
LID - 10.1021/acsbiomaterials.9b00153 [doi]
AB  - Following supramolecular synthon rationale in the context of crystal engineering, 
      a nonsteroidal-anti-inflammatory-drug (NSAID), namely flufenamic acid (FA) and 
      its beta-alanine monopeptide derivative (FM), were converted to a series of primary 
      ammonium monocarboxylate (PAM) salts. Majority of the PAM salts ( approximately 90%) showed 
      gelation with various solvents including water and methyl salicylate (important 
      solvents in topical gel formulation). Structure-property correlation studies 
      based on single-crystal X-ray diffraction (SXRD) and powder X-ray diffraction 
      (PXRD) data provided intriguing insights into the structure of the gel network. 
      Furthermore, one of the gelator salts (S7) displayed anticancer activity on a 
      highly aggressive human breast cancer cell line (MDA-MB-231) ,as revealed by MTT, 
      PEG(2), and cell migration assays.
FAU - Parveen, Rumana
AU  - Parveen R
AD  - School of Chemical Sciences, Indian Association for the Cultivation of Science, 
      2A & 2B Raja S.C. Mullick Road, Kolkata 700032,West Bengal, India.
FAU - Jayamma, Bandi
AU  - Jayamma B
AD  - School of Chemical Sciences, Indian Association for the Cultivation of Science, 
      2A & 2B Raja S.C. Mullick Road, Kolkata 700032,West Bengal, India.
FAU - Dastidar, Parthasarathi
AU  - Dastidar P
AUID- ORCID: 0000-0002-1011-2386
AD  - School of Chemical Sciences, Indian Association for the Cultivation of Science, 
      2A & 2B Raja S.C. Mullick Road, Kolkata 700032,West Bengal, India.
LA  - eng
PT  - Journal Article
DEP - 20190415
PL  - United States
TA  - ACS Biomater Sci Eng
JT  - ACS biomaterials science & engineering
JID - 101654670
SB  - IM
OTO - NOTNLM
OT  - SAFiNs
OT  - anti-inflammatory
OT  - anticancer
OT  - cell migration
OT  - supramolecular gels
EDAT- 2019/05/13 00:00
MHDA- 2019/05/13 00:01
CRDT- 2021/01/06 17:11
PHST- 2021/01/06 17:11 [entrez]
PHST- 2019/05/13 00:00 [pubmed]
PHST- 2019/05/13 00:01 [medline]
AID - 10.1021/acsbiomaterials.9b00153 [doi]
PST - ppublish
SO  - ACS Biomater Sci Eng. 2019 May 13;5(5):2180-2189. doi: 
      10.1021/acsbiomaterials.9b00153. Epub 2019 Apr 15.