PMID- 33406850
OWN - NLM
STAT- MEDLINE
DCOM- 20210510
LR  - 20221207
IS  - 1940-1574 (Electronic)
IS  - 0003-3197 (Linking)
VI  - 72
IP  - 5
DP  - 2021 May
TI  - Evaluation of Clinical Outcomes After Revascularization in Patients With Chronic 
      Limb-Threatening Ischemia: Results From a Prospective National Cohort Study 
      (RIVALUTANDO).
PG  - 480-489
LID - 10.1177/0003319720980619 [doi]
AB  - We evaluated the outcomes of revascularization in patients with chronic 
      limb-threatening ischemia (CLTI) treated in real-world settings. This is a 
      prospective multicenter cohort study with 12-month follow-up enrolling patients 
      (n = 287) with CLTI undergoing open, endovascular, or hybrid lower extremity 
      revascularization. The primary end point was amputation-free survival (AFS) at 12 
      months. Cox proportional analysis was used to determine independent predictors of 
      amputation and restenosis. At 30 days, major adverse cardiovascular and major 
      adverse limb events (MALE) rates were 3.1% and 2.1%, respectively. At 1 year, the 
      overall survival rate was 88.8%, the AFS was 86.6%, and the primary patency was 
      70.5%. Freedom from MALE was 62.5%. After multivariate analysis, smoking (hazard 
      ratio [HR] = 2.2, P = 0.04), renal failure (HR = 2.3, P = 0.03), Rutherford class 
      (>/=5) (HR = 3.2, P = 0.01), and below-the-knee disease (HR = 2.0, P = 0.05) were 
      significant predictors of amputation; iloprost infusion (>10 vials) (HR = 0.64, P 
      = 0.05) was a significant protective factor. Cilostazol administration (HR = 
      0.77, P = 0.05) was a significant protective factor for restenosis. Results from 
      this prospective multicenter registry offer a consistent overview of clinical 
      outcomes of CLTI patients at 1 year when adequately revascularized. Medical 
      treatment, including statins, cilostazol and iloprost, were associated with 
      improved 1-year freedom from restenosis and amputation.
FAU - de Donato, Gianmarco
AU  - de Donato G
AUID- ORCID: 0000-0003-2451-8501
AD  - Vascular Surgery, 9313University of Siena, Italy.
FAU - Benedetto, Filippo
AU  - Benedetto F
AD  - Vascular Surgery, 18980University of Messina, Italy.
FAU - Stilo, Francesco
AU  - Stilo F
AD  - Vascular Surgery, University of Rome Campus Biomedico, Italy.
FAU - Chiesa, Roberto
AU  - Chiesa R
AD  - Vascular Surgery, University of Milano San Rafael, Italy.
FAU - Palombo, Domenico
AU  - Palombo D
AD  - Vascular Surgery, 9302University of Genova, Italy.
FAU - Pasqui, Edoardo
AU  - Pasqui E
AD  - Vascular Surgery, 9313University of Siena, Italy.
FAU - Panzano, Claudia
AU  - Panzano C
AD  - Vascular Surgery, 9313University of Siena, Italy.
FAU - Pulli, Raffaele
AU  - Pulli R
AD  - Vascular Surgery, 9295University of Bari, Italy.
FAU - Novali, Claudio
AU  - Novali C
AD  - Vascular Surgery, Hospital of Cuneo, Italy.
FAU - Silingardi, Roberto
AU  - Silingardi R
AD  - Vascular Surgery, 9306University of Modena, Italy.
FAU - Grego, Francesco
AU  - Grego F
AD  - Vascular Surgery, 9308University of Padova, Italy.
FAU - Palasciano, Giancarlo
AU  - Palasciano G
AD  - Vascular Surgery, 9313University of Siena, Italy.
FAU - Setacci, Carlo
AU  - Setacci C
AD  - Vascular Surgery, 9313University of Siena, Italy.
CN  - RIVALUTANDO Collaborators
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20210107
PL  - United States
TA  - Angiology
JT  - Angiology
JID - 0203706
RN  - 0 (Cardiovascular Agents)
SB  - IM
MH  - Aged
MH  - Amputation, Surgical
MH  - Cardiovascular Agents/therapeutic use
MH  - Chronic Disease
MH  - *Endovascular Procedures/adverse effects/mortality
MH  - Female
MH  - Humans
MH  - Ischemia/diagnostic imaging/mortality/*surgery
MH  - Italy
MH  - Limb Salvage
MH  - Male
MH  - Peripheral Arterial Disease/diagnostic imaging/mortality/*surgery
MH  - Prospective Studies
MH  - Recurrence
MH  - Registries
MH  - Risk Assessment
MH  - Risk Factors
MH  - Time Factors
MH  - Treatment Outcome
MH  - *Vascular Surgical Procedures/adverse effects/mortality
OTO - NOTNLM
OT  - chronic limb-threatening ischemia
OT  - limb salvage
OT  - medical treatment
OT  - peripheral arterial disease
OT  - revascularization
FIR - G, Angiletta
IR  - G A
IRAD- Vascular Surgery, 9295University of Bari, Italy.
FIR - C, Rivellini
IR  - C R
IRAD- Vascular Surgery, Hospital of Cuneo, Italy.
FIR - B, Pane
IR  - B P
IRAD- Vascular Surgery, 9302University of Genova, Italy.
FIR - G, Spinella
IR  - G S
IRAD- Vascular Surgery, 9302University of Genova, Italy.
FIR - N, Pipito
IR  - N P
IRAD- Vascular Surgery, 18980University of Messina, Italy.
FIR - D, Spinelli
IR  - D S
IRAD- Vascular Surgery, 18980University of Messina, Italy.
FIR - G, Derone
IR  - G D
IRAD- Vascular Surgery, 18980University of Messina, Italy.
FIR - A, Kahlberg
IR  - A K
IRAD- Vascular Surgery, University of Milano San Rafael, Italy.
FIR - N, Carta
IR  - N C
IRAD- Vascular Surgery, University of Milano San Rafael, Italy.
FIR - A, Lauricella
IR  - A L
IRAD- Vascular Surgery, 9306University of Modena, Italy.
FIR - L, Maresca
IR  - L M
IRAD- Vascular Surgery Monaldi Hospital of Napoli
FIR - M, Antonello
IR  - M A
IRAD- Vascular Surgery, 9308University of Padova, Italy.
FIR - M, Piazza
IR  - M P
IRAD- Vascular Surgery, 9308University of Padova, Italy.
FIR - S, Bonvini
IR  - S B
IRAD- Vascular Surgery, 9308University of Padova, Italy.
FIR - V, Wassermann
IR  - V W
IRAD- Vascular Surgery, 9308University of Padova, Italy.
FIR - A, Trani
IR  - A T
IRAD- Vascular Surgery Hospital of Potenza
FIR - A, Barresi
IR  - A B
IRAD- Vascular Surgery Hospital of Ragusa
FIR - G, Di Citra
IR  - G DC
IRAD- Vascular Surgery Hospital of Ragusa
FIR - F, Spinelli
IR  - F S
FIR - N, Montelione
IR  - N M
IRAD- Vascular Surgery University Campus Biomedico of Roma
FIR - G, Paroni
IR  - G P
IRAD- Vascular Surgery Hospital of San Giovanni Rotondo
FIR - G, Magistro
IR  - G M
IRAD- Vascular Surgery Hospital of San Giovanni Rotondo
FIR - D, Ceriello
IR  - D C
IRAD- Vascular Surgery Hospital of San Giovanni Rotondo
FIR - M, Merlo
IR  - M M
IRAD- Vascular Surgery Hospital of Torino
FIR - F, Giordano
IR  - F G
IRAD- Vascular Surgery Hospital of Torino
FIR - U, Ruzzi
IR  - U R
IRAD- Vascular Surgery, 9313University of Siena, Italy.
FIR - G, Mazzitelli
IR  - G M
IRAD- Vascular Surgery, 9313University of Siena, Italy.
FIR - M, Mele
IR  - M M
IRAD- Vascular Surgery, 9313University of Siena, Italy.
FIR - G, Giannace
IR  - G G
IRAD- Vascular Surgery, 9313University of Siena, Italy.
FIR - G, Alba
IR  - G A
IRAD- Vascular Surgery, 9313University of Siena, Italy.
FIR - G, Grottola
IR  - G G
IRAD- Vascular Surgery, 9313University of Siena, Italy.
FIR - M, Pazzaglia
IR  - M P
IRAD- Vascular Surgery, 9313University of Siena, Italy.
FIR - G, Giubbolini
IR  - G G
IRAD- Vascular Surgery, 9313University of Siena, Italy.
FIR - B, Baldi
IR  - B B
IRAD- Vascular Surgery, 9313University of Siena, Italy.
FIR - W, Guerrieri
IR  - W G
IRAD- Vascular Surgery, 9313University of Siena, Italy.
FIR - D, Benevento
IR  - D B
IRAD- Vascular Surgery, 9313University of Siena, Italy.
FIR - A, Cappelli
IR  - A C
IRAD- Vascular Surgery, 9313University of Siena, Italy.
EDAT- 2021/01/08 06:00
MHDA- 2021/05/11 06:00
CRDT- 2021/01/07 05:40
PHST- 2021/01/08 06:00 [pubmed]
PHST- 2021/05/11 06:00 [medline]
PHST- 2021/01/07 05:40 [entrez]
AID - 10.1177/0003319720980619 [doi]
PST - ppublish
SO  - Angiology. 2021 May;72(5):480-489. doi: 10.1177/0003319720980619. Epub 2021 Jan 
      7.