PMID- 33406897
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221029
IS  - 2192-5682 (Print)
IS  - 2192-5690 (Electronic)
IS  - 2192-5682 (Linking)
VI  - 12
IP  - 8
DP  - 2022 Oct
TI  - Lumbar Fusion Surgery for Patients With Back Pain and Degenerative Disc Disease: 
      An Observational Study From the Canadian Spine Outcomes and Research Network.
PG  - 1676-1686
LID - 10.1177/2192568220985470 [doi]
AB  - STUDY DESIGN: Uncontrolled retrospective observational study. OBJECTIVES: Surgery 
      for patients with back pain and degenerative disc disease is controversial, and 
      studies to date have yielded conflicting results. We evaluated the effects of 
      lumbar fusion surgery for patients with this indication in the Canadian Spine 
      Outcomes and Research Network (CSORN). METHODS: We analyzed data that were 
      prospectively collected from consecutive patients at 11 centers between 2015 and 
      2019. Our primary outcome was change in patient-reported back pain at 12 months 
      of follow-up, and our secondary outcomes were satisfaction, disability, 
      health-related quality of life, and rates of adverse events. RESULTS: Among 84 
      patients, we observed a statistically significant improvement of back pain at 12 
      months that exceeded the threshold of Minimum Clinically Important Difference 
      (MCID) (mean change -3.7 points, SD 2.6, p < 0.001, MCID = 1.2; 77% achieved 
      MCID), and 81% reported being "somewhat" or "extremely" satisfied. We also 
      observed improvements of Oswestry Disability Index (-17.3, SD 16.6), Short 
      Form-12 Physical Component Summary (10.3, SD 9.6) and Short Form-12 Mental 
      Component Summary (3.1, SD 8.3); all p < 0.001). The overall rate of adverse 
      events was 19%. CONCLUSIONS: Among a highly selective group of patients 
      undergoing lumbar fusion surgery for degenerative disc disease, most experienced 
      a clinically significant improvement of back pain as well as significant 
      improvements of disability and health-related quality of life, with high 
      satisfaction at 1 year of follow-up. These findings suggest that surgery for this 
      indication may provide some benefit, and that further research is warranted.
FAU - Evaniew, Nathan
AU  - Evaniew N
AUID- ORCID: 0000-0003-1974-5224
AD  - University of Calgary Spine Program, University of Calgary, Alberta, Canada.
FAU - Swamy, Ganesh
AU  - Swamy G
AD  - University of Calgary Spine Program, University of Calgary, Alberta, Canada.
FAU - Jacobs, W Bradley
AU  - Jacobs WB
AD  - University of Calgary Spine Program, University of Calgary, Alberta, Canada.
FAU - Bouchard, Jacques
AU  - Bouchard J
AD  - University of Calgary Spine Program, University of Calgary, Alberta, Canada.
FAU - Cho, Roger
AU  - Cho R
AD  - University of Calgary Spine Program, University of Calgary, Alberta, Canada.
FAU - Manson, Neil A
AU  - Manson NA
AD  - Canada East Spine Centre, Saint John, New Brunswick, Canada.
FAU - Rampersaud, Y Raja
AU  - Rampersaud YR
AD  - Department of Surgery, University of Toronto, Ontario, Canada.
FAU - Paquet, Jerome
AU  - Paquet J
AD  - Departement de Chirurgie, Universite Laval, Quebec City, Quebec, Canada.
FAU - Bailey, Christopher S
AU  - Bailey CS
AD  - Department of Surgery, Western University, London, Ontario, Canada.
FAU - Johnson, Michael
AU  - Johnson M
AD  - Department of Surgery, University of Manitoba, Winnipeg, Manitoba, Canada.
FAU - Attabib, Najmedden
AU  - Attabib N
AD  - Canada East Spine Centre, Saint John, New Brunswick, Canada.
FAU - Fisher, Charles G
AU  - Fisher CG
AD  - Department of Orthopaedics, University of British Columbia, Vancouver, British 
      Columbia, Canada.
FAU - McIntosh, Greg
AU  - McIntosh G
AUID- ORCID: 0000-0002-0268-6523
AD  - Canadian Spine Outcomes and Research Network, Markdale, Ontario, Canada.
FAU - Thomas, Kenneth C
AU  - Thomas KC
AD  - University of Calgary Spine Program, University of Calgary, Alberta, Canada.
LA  - eng
PT  - Journal Article
DEP - 20210107
PL  - England
TA  - Global Spine J
JT  - Global spine journal
JID - 101596156
PMC - PMC9609527
OTO - NOTNLM
OT  - back pain
OT  - degenerative disc disease
OT  - fusion
OT  - lumbar
OT  - operation
OT  - spine surgery
COIS- The author(s) declared no potential conflicts of interest with respect to the 
      research, authorship, and/or publication of this article.
EDAT- 2021/01/08 06:00
MHDA- 2021/01/08 06:01
PMCR- 2021/01/07
CRDT- 2021/01/07 05:40
PHST- 2021/01/08 06:00 [pubmed]
PHST- 2021/01/08 06:01 [medline]
PHST- 2021/01/07 05:40 [entrez]
PHST- 2021/01/07 00:00 [pmc-release]
AID - 10.1177_2192568220985470 [pii]
AID - 10.1177/2192568220985470 [doi]
PST - ppublish
SO  - Global Spine J. 2022 Oct;12(8):1676-1686. doi: 10.1177/2192568220985470. Epub 
      2021 Jan 7.