PMID- 33407124
OWN - NLM
STAT- MEDLINE
DCOM- 20211206
LR  - 20211214
IS  - 1471-2172 (Electronic)
IS  - 1471-2172 (Linking)
VI  - 22
IP  - 1
DP  - 2021 Jan 6
TI  - The role of beta(2) integrin in dendritic cell migration during infection.
PG  - 2
LID - 10.1186/s12865-020-00394-5 [doi]
LID - 2
AB  - BACKGROUND: Dendritic cells (DCs) play a key role in shaping T cell responses. To 
      do this, DCs must be able to migrate to the site of the infection and the lymph 
      nodes to prime T cells and initiate the appropriate immune response. Integrins 
      such as beta(2) integrin play a key role in leukocyte adhesion, migration, and cell 
      activation. However, the role of beta(2) integrin in DC migration and function in 
      the context of infection-induced inflammation in the gut is not well understood. 
      This study looked at the role of beta(2) integrin in DC migration and function 
      during infection with the nematode worm Trichuris muris. Itgb2(tm1Bay) mice 
      lacking functional beta(2) integrin and WT littermate controls were infected with T. 
      muris and the response to infection and kinetics of the DC response was assessed. 
      RESULTS: In infection, the lack of functional beta(2) integrin significantly reduced 
      DC migration to the site of infection but not the lymph nodes. The lack of 
      functional beta(2) integrin did not negatively impact T cell activation in response 
      to T. muris infection. CONCLUSIONS: This data suggests that beta(2) integrins are 
      important in DC recruitment to the infection site potentially impacting the 
      initiation of innate immunity but is dispensible for DC migration to lymph nodes 
      and T cell priming in the context of T. muris infection.
FAU - Altorki, Tarfa
AU  - Altorki T
AD  - Faculty of Biology, Medicine and Health, Lydia Becker Institute of Immunology and 
      Inflammation, Manchester Academic Health Science Centre, A.V. Hill Building, The 
      University of Manchester, Oxford Road, Manchester, M13 9PT, UK.
AD  - Present address: Faculty of Medical Applied Sciences, Department of Medical 
      Laboratory Sciences, King Abdul-Aziz University, Jeddah, Saudi Arabia.
FAU - Muller, Werner
AU  - Muller W
AD  - Faculty of Biology, Medicine and Health, Lydia Becker Institute of Immunology and 
      Inflammation, Manchester Academic Health Science Centre, A.V. Hill Building, The 
      University of Manchester, Oxford Road, Manchester, M13 9PT, UK.
FAU - Brass, Andrew
AU  - Brass A
AD  - Faculty of Biology, Medicine and Health, Division of Informatics, Imaging and 
      Data Sciences, Stopford Building, The University of Manchester, Oxford Road, 
      Manchester, M13 9PT, UK.
FAU - Cruickshank, Sheena
AU  - Cruickshank S
AD  - Faculty of Biology, Medicine and Health, Lydia Becker Institute of Immunology and 
      Inflammation, Manchester Academic Health Science Centre, A.V. Hill Building, The 
      University of Manchester, Oxford Road, Manchester, M13 9PT, UK. 
      Sheena.Cruickshank@manchester.ac.uk.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210106
PL  - England
TA  - BMC Immunol
JT  - BMC immunology
JID - 100966980
RN  - 0 (CD18 Antigens)
SB  - IM
MH  - Animals
MH  - CD18 Antigens/deficiency/*immunology
MH  - Cell Movement/*immunology
MH  - Dendritic Cells/*immunology
MH  - Macrophages/immunology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Mutant Strains
MH  - Trichuriasis/immunology
MH  - Trichuris
PMC - PMC7789014
OTO - NOTNLM
OT  - Dendritic cell
OT  - Immune response
OT  - Infection
OT  - Migration
OT  - beta2 integrin
COIS- The authors have no competing interests to declare.
EDAT- 2021/01/08 06:00
MHDA- 2021/12/15 06:00
PMCR- 2021/01/06
CRDT- 2021/01/07 05:42
PHST- 2020/09/18 00:00 [received]
PHST- 2020/11/10 00:00 [accepted]
PHST- 2021/01/07 05:42 [entrez]
PHST- 2021/01/08 06:00 [pubmed]
PHST- 2021/12/15 06:00 [medline]
PHST- 2021/01/06 00:00 [pmc-release]
AID - 10.1186/s12865-020-00394-5 [pii]
AID - 394 [pii]
AID - 10.1186/s12865-020-00394-5 [doi]
PST - epublish
SO  - BMC Immunol. 2021 Jan 6;22(1):2. doi: 10.1186/s12865-020-00394-5.